Clinical usefulness of intravenous constant rate infusion of fentanyl and medetomidine under sevoflurane anesthesia in Thoroughbred racehorses undergoing internal fixation surgery.
Abstract: A total of 20 racehorses with longitudinal fractures underwent internal fixation surgery under sevoflurane anesthesia combined with infusion of medetomidine (3 µg/kg/hr) alone (10 horses, group M) or medetomidine and fentanyl (7 µg/kg/hr) (10 horses, group FM). In group FM, the end-tidal sevoflurane concentration during surgery was maintained significantly lower than in group M (2.8-2.9% for group M vs. 2.2-2.6% for group FM, P<0.01). The mean arterial blood pressure was maintained over 70 mmHg using dobutamine infusion (group M, 0.36-0.54 µg/kg/min; group FM, 0.27-0.65 µg/kg/min), and the recovery qualities were clinically acceptable in both groups. In conclusion, co-administration of fentanyl and medetomidine by constant rate infusion may be a clinically useful intraoperative anesthetic adjunct for horses to reduce the requirement of sevoflurane when they undergo orthopedic surgery.
Publication Date: 2017-12-16 PubMed ID: 29270071PubMed Central: PMC5735311DOI: 10.1294/jes.28.143Google Scholar: Lookup
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- Journal Article
Summary
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The research revolves around the use of a combination of fentanyl and medetomidine under sevoflurane anesthesia during internal fixation surgery in racehorses, and how it results in a reduced requirement of sevoflurane, and thus may be considered a clinically useful anesthesia practice for horses undergoing orthopedic surgery.
Study Design and Participants
- The study involved 20 racehorses with longitudinal fractures who were subjected to internal fixation surgery. The horses were split into two groups: those receiving medetomidine alone (group M) and those receiving a combination of medetomidine and fentanyl (group FM).
Procedure and Observation
- Both groups were put under sevoflurane anesthesia, a common inhalant anesthetic used in veterinary medicine.
- In group FM where a combination of medetomidine and fentanyl was used, a significantly lower concentration of sevoflurane was needed during surgery as compared to group M (2.2-2.6% for group FM vs. 2.8-2.9% for group M). This indicates that the combination treatment allowed a lower dose of sevoflurane to be effective.
Significance of Findings
- The research revealed that the co-administration of fentanyl and medetomidine at a constant rate could be beneficial in reducing the requirement of sevoflurane during surgery, thus possibly reducing the risk or intensity of potential adverse effects linked to the usage of inhalant anesthetics.
- The study also showed that the mean arterial blood pressure was maintained above 70 mmHg using dobutamine infusion in both groups, suggesting that this anesthetic regimen didn’t negatively affect blood pressure.
- Recovery qualities were found to be clinically acceptable in both groups, further supporting the use of these anesthetic combinations.
- The findings may have implications in veterinary anesthesia, particularly in managing anesthetic protocol in horses undergoing orthopedic surgeries.
Cite This Article
APA
Mizobe F, Wakuno A, Okada J, Otsuka T, Ishikawa Y, Kurimoto S.
(2017).
Clinical usefulness of intravenous constant rate infusion of fentanyl and medetomidine under sevoflurane anesthesia in Thoroughbred racehorses undergoing internal fixation surgery.
J Equine Sci, 28(4), 143-147.
https://doi.org/10.1294/jes.28.143 Publication
Researcher Affiliations
- Racehorse Hospital, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
- Racehorse Hospital, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
- Racehorse Hospital, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
- Racehorse Hospital, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
- Racehorse Hospital, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
- Racehorse Hospital, Ritto Training Center, Japan Racing Association, Shiga 520-3085, Japan.
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This article includes 20 references
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Citations
This article has been cited 1 times.- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
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