Cloprostenol in equine reproductive practice: something more than a luteolytic drug.
Abstract: Prostaglandin F(2α) and its analogues (PGF) are widely used in equine reproductive practice. The interval from PGF treatment to ovulation (ITO) varies greatly with a range from 2 to 16 days. Clinical observation suggests that mares mated and ovulated soon after PGF treatment may have poor fertility. Reproductive records of 329 cyclic Thoroughbred mares were analysed retrospectively. The following parameters were analysed: (i) use of cloprostenol; (ii) ITO and (iii) number of ovulations per cycle. According to these parameters, mares were classified into four groups. (i) mares with spontaneous ovulations, n = 57; (ii) mares induced with cloprostenol and ITO = 4-7 days, n = 77; (iii) ITO = 8-10 days, n = 89 and (iv) ITO = ≥ 11 days, n = 106. Differences in pregnancy (PR) and multiple ovulation (MO) rates among groups were tested using chi-squared test. PR rates for groups 1-4 were: 73.7%, 46.7%, 64% and 71.7% respectively (p < 0.05). Groups 1 and 2 had lower (p < 0.05) MO rate (24.6% and 20.8%) than groups 3 and 4 (40.4% and 44.3%). It appears that ovulation soon after PGF-induced luteolysis is detrimental to PR rates. It was found highly significant that in cloprostenol-treated mares, the MO rate was enhanced without subsequent increase in multiple pregnancies.
© 2009 Blackwell Verlag GmbH.
Publication Date: 2009-08-05 PubMed ID: 19650878DOI: 10.1111/j.1439-0531.2009.01508.xGoogle Scholar: Lookup
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Summary
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This research article examined the impact of the drug cloprostenol, a prostaglandin F(2α) analogue, on the ovulation and fertility rates in Thoroughbred mares. The study found a distinct connection between the timing of ovulation after drug treatment and pregnancy outcomes, as well as effects on multiple ovulation rates.
Study Methodology
- The researchers used reproductive records of 329 cyclic Thoroughbred mares.
- They analyzed three parameters – the use of cloprostenol, the interval from treatment to ovulation (ITO), and the number of ovulations per cycle.
- Basing on these parameters, mares were divided into four groups – mares with spontaneous ovulations, mares induced with cloprostenol with an ITO of 4-7 days, an ITO of 8-10 days, and an ITO of 11 days or more.
Findings
- Statistical analysis showed significant differences in pregnancy rates among the four groups.
- Mares ovulating soon after treatment with prostaglandin F(2α) showed decreased pregnancy rates.
- Pregnancy rates ranged from only 46.7% in the group with an ITO of 4-7 days to 73.7% in the mares with spontaneous ovulations.
- On the other hand, intriguingly, the multiple ovulation (MO) rate was increased in the cloprostenol-treated mares, but didn’t result in a proportional increase in multiple pregnancies.
- Mares with an ITO of 8 or more days had higher MO rates (ranging from 40.4% to 44.3%) compared to those with shorter ITOs or spontaneous ovulations (ranging from 20.8% to 24.6%).
Implications
- The findings suggest that the timing of ovulation after cloprostenol treatment significantly impacts fertility. It appears that an ovulation that occurs too early in the cycle, soon after treatment, has a negative effect on pregnancy rates.
- Additionally, while cloprostenol appears to increase multiple ovulation rates, it does not necessarily result in an increase in multiple pregnancies. This distinction indicates a need for more research into the impacts of cloprostenol on equine reproductive processes.
Cite This Article
APA
Cuervo-Arango J, Newcombe JR.
(2009).
Cloprostenol in equine reproductive practice: something more than a luteolytic drug.
Reprod Domest Anim, 45(5), e8-e11.
https://doi.org/10.1111/j.1439-0531.2009.01508.x Publication
Researcher Affiliations
- Departamento Medicina y Cirugía Animal, Facultad de Ciencias Experimentales y de la Salud, Universidad CEU-Cardenal Herrera, Edificio Seminario, Moncada, Spain. copicuervo@hotmail.com
MeSH Terms
- Animals
- Cloprostenol / pharmacology
- Estrus / drug effects
- Female
- Horses / physiology
- Luteolysis / drug effects
- Luteolytic Agents / pharmacology
- Ovulation / drug effects
- Ovulation / physiology
- Pregnancy
- Pregnancy Rate
- Reproduction
- Retrospective Studies
Citations
This article has been cited 1 times.- Bottrel M, Ortiz I, Hidalgo M, Díaz-Jiménez M, Pereira B, Consuegra C, Yousef MS, Dorado J. Hormonal Management for the Induction of Luteolysis and Ovulation in Andalusian Jennies: Effect on Reproductive Performance, Embryo Quality and Recovery Rate.. Animals (Basel) 2022 Jan 8;12(2).
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