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Cobalt 60 radiotherapy for treatment of squamous cell carcinoma of the nasal cavity and paranasal sinuses in three horses.

Abstract: Three adult horses underwent aggressive treatment of squamous cell carcinoma of the nasal cavity and paranasal sinuses, using course-fractionated cobalt 60 radiotherapy. Squamous cell carcinoma of the nasal cavity and paranasal sinuses is not commonly diagnosed in horses. Historically, horses with this type of neoplasm have not been treated or have undergone some form of surgery. The prognosis for long-term survival or cure has been poor. Long-term results of cobalt 60 radiotherapy were good to excellent and exceeded those usually reported for horses treated surgically. On the basis of these results, use of radiotherapy for these neoplasms is recommended.
Publication Date: 1998-04-08 PubMed ID: 9530425
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Summary

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This research explores the use of cobalt 60 radiotherapy to aggressively treat squamous cell carcinoma (a type of cancer) in the nasal cavity and paranasal sinuses of three horses, finding promising long-term results that exceed typical surgical outcomes.

Study Overview

  • The study subjects were three adult horses diagnosed with squamous cell carcinoma in the nasal cavity and paranasal sinuses. This is an uncommon occurrence, and usually, the prognosis for long-term survival is poor.
  • Historically, horses with this type of cancer either went untreated or underwent some form of surgery. The research, however, introduced cobalt 60 radiotherapy as a form of treatment.

Radiotherapy Treatment

  • The horses underwent aggressive course-fractionated cobalt 60 radiotherapy treatment. In this type of treatment, cobalt 60, a radioactive isotope, is employed to kill the cancer cells. The treatment is course-fractionated, meaning it is divided into fractions or doses over time.
  • The goal of the treatment was to offer an effective alternative to surgery and to improve the prognosis for horses with this rare type of cancer.

Results and Conclusion

  • The findings from the study were promising, showing good to excellent long-term results from the cobalt 60 radiotherapy treatment. The outcomes were seen to exceed those typically seen in horses treated surgically for the same type of neoplasm.
  • Given the success of the treatment in these cases, the study recommends the use of radiotherapy for such neoplasms in horses.

Cite This Article

APA
Walker MA, Schumacher J, Schmitz DG, McMullen WC, Ruoff WW, Crabill MR, Hawkins JF, Hogan PM, McClure SR, Vacek JR, Edwards JF, Helman RG, Frelier PF. (1998). Cobalt 60 radiotherapy for treatment of squamous cell carcinoma of the nasal cavity and paranasal sinuses in three horses. J Am Vet Med Assoc, 212(6), 848-851.

Publication

ISSN: 0003-1488
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 212
Issue: 6
Pages: 848-851

Researcher Affiliations

Walker, M A
  • Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843-4475, USA.
Schumacher, J
    Schmitz, D G
      McMullen, W C
        Ruoff, W W
          Crabill, M R
            Hawkins, J F
              Hogan, P M
                McClure, S R
                  Vacek, J R
                    Edwards, J F
                      Helman, R G
                        Frelier, P F

                          MeSH Terms

                          • Animals
                          • Carcinoma, Squamous Cell / diagnostic imaging
                          • Carcinoma, Squamous Cell / radiotherapy
                          • Carcinoma, Squamous Cell / veterinary
                          • Cobalt Radioisotopes / therapeutic use
                          • Female
                          • Horse Diseases / diagnostic imaging
                          • Horse Diseases / radiotherapy
                          • Horses
                          • Male
                          • Nasal Cavity
                          • Nose Neoplasms / diagnostic imaging
                          • Nose Neoplasms / radiotherapy
                          • Nose Neoplasms / veterinary
                          • Paranasal Sinus Neoplasms / diagnostic imaging
                          • Paranasal Sinus Neoplasms / radiotherapy
                          • Paranasal Sinus Neoplasms / veterinary
                          • Radiography

                          Citations

                          This article has been cited 2 times.
                          1. Wotman KL, Chow L, Martabano B, Pezzanite LM, Dow S. Novel ocular immunotherapy induces tumor regression in an equine model of ocular surface squamous neoplasia.. Cancer Immunol Immunother 2023 May;72(5):1185-1198.
                            doi: 10.1007/s00262-022-03321-2pubmed: 36367558google scholar: lookup
                          2. Gillen A, Mudge M, Caldwell F, Munsterman A, Hanson R, Brawner W, Almond G, Green E, Stephens J, Walz J. Outcome of external beam radiotherapy for treatment of noncutaneous tumors of the head in horses: 32 cases (1999-2015).. J Vet Intern Med 2020 Nov;34(6):2808-2816.
                            doi: 10.1111/jvim.15954pubmed: 33165966google scholar: lookup