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The Canadian veterinary journal = La revue veterinaire canadienne2014; 55(5); 471-474; doi: 10.1016/j.vetmic.2013.03.032

Colonic gastrointestinal stromal tumor resulting in recurrent colic and hematochezia in a warmblood gelding.

Abstract: A 14-year-old Trakehner gelding was evaluated for recurrent colic, with episodes occurring over 1 year. Signs were consistent with intermittent ascending colon obstruction and hematochezia. Necropsy examination revealed an ulcerated mass extending into the lumen of the right dorsal ascending colon. Gross and histologic appearance and immunoreactivity to c-kit (CD117), desmin, vimentin, and smooth muscle actin, were consistent with a diagnosis of gastrointestinal stromal tumor. Tumeur ventrale gastro-intestinale du côlon produisant des coliques et de l’hématochézie et des coliques récurrentes chez un hongre à sang chaud. Un hongre Trakehner âgé de 14 ans a été évalué pour des coliques récurrentes et les épisodes duraient depuis 1 an. Les signes étaient conformes à une obstruction intermittente du côlon ascendant et à l’hématochézie. La nécropsie a révélé une masse ulcéreuse s’étendant dans la lumière du côlon ascendant dorsal droit. L’apparence brute et histologique et l’immunoréactivité à c-kit (CD117), à la desmine, à la vimentine et à l’actine des muscles lisses étaient conformes au diagnostic de tumeur ventrale gastro-intestinale.(Traduit par Isabelle Vallières).
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Publication Date: 2014-05-03 PubMed ID: 24790234PubMed Central: PMC3992309DOI: 10.1016/j.vetmic.2013.03.032Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study describes the case of a 14-year-old horse that suffered from a gastrointestinal stromal tumor in the colon, causing recurrent colic and bloody stool for a year.

Clinical Presentation

  • The horse under study was a 14-year-old Trakehner gelding. Trakehner is a warmblood horse breed of East Prussian origin, known for their strength, stamina, and agility. Gelding refers to a castrated male horse.
  • The horse was suffering from recurrent colic (severe, often fluctuating pain in the abdomen that is caused by the spasm or obstruction of any hollow or tubular soft organ) that had been happening occasionally over a period of one year.
  • The horse also exhibited hematochezia, which is the passage of fresh blood via the anus, usually in or with stools. This is a clear sign of a significant problem in the digestive system.

Diagnosis and Findings

  • The horse was suspected to have an intermittent blockage in the rising colon (ascending colon), which is the part of the large intestine that carries feces from the cecum to the transverse colon.
  • During an autopsy, an ulcerated mass was found in the lumen (the inside space) of the right dorsal ascending colon. Dorsal refers to the upper side or back of an animal. So, in this case, it’s the upper part of the colon.
  • The mass was examined both visually (gross appearance) and under a microscope (histologic appearance).

Confirmation of the Tumor

  • The mass in the colon exhibited immunoreactivity to several proteins – c-kit (CD117), desmin, vimentin, and smooth muscle actin. This means the mass produced an immune response to these proteins.
  • These proteins are normally associated with gastrointestinal stromal tumors (GIST), a type of tumor that occurs in the gastrointestinal tract.
  • The visual and microscopic appearance of the mass, along with its immunoreactivity to the specific proteins, confirmed its diagnosis as a GIST.

In conclusion, the study documents a rare case of a gastrointestinal stromal tumor in a horse resulting in recurrent colic and hematochezia. The findings highlight the need for early diagnosis and appropriate treatment, illustrating the potential severity and lethality of GISTs in horses.

Cite This Article

APA
Malberg JA, Webb BT, Hackett ES. (2014). Colonic gastrointestinal stromal tumor resulting in recurrent colic and hematochezia in a warmblood gelding. Can Vet J, 55(5), 471-474. https://doi.org/10.1016/j.vetmic.2013.03.032

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 55
Issue: 5
Pages: 471-474

Researcher Affiliations

Malberg, Jessica A
  • Colorado State University, Department of Clinical Sciences, 300 West Drake Road, Fort Collins, Colorado 80523, USA (Malberg, Hackett); North Dakota State University, Veterinary Diagnostic Laboratory, Dept. 7691, PO Box 6050, Fargo, North Dakota 58108, USA (Webb).
Webb, Brett T
  • Colorado State University, Department of Clinical Sciences, 300 West Drake Road, Fort Collins, Colorado 80523, USA (Malberg, Hackett); North Dakota State University, Veterinary Diagnostic Laboratory, Dept. 7691, PO Box 6050, Fargo, North Dakota 58108, USA (Webb).
Hackett, Eileen S
  • Colorado State University, Department of Clinical Sciences, 300 West Drake Road, Fort Collins, Colorado 80523, USA (Malberg, Hackett); North Dakota State University, Veterinary Diagnostic Laboratory, Dept. 7691, PO Box 6050, Fargo, North Dakota 58108, USA (Webb).

MeSH Terms

  • Animals
  • Colic / etiology
  • Colic / veterinary
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / veterinary
  • Gastrointestinal Hemorrhage / etiology
  • Gastrointestinal Hemorrhage / veterinary
  • Gastrointestinal Stromal Tumors / complications
  • Gastrointestinal Stromal Tumors / pathology
  • Gastrointestinal Stromal Tumors / veterinary
  • Horse Diseases / diagnosis
  • Horse Diseases / pathology
  • Horses
  • Male

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