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Home / Equine Research Bank / Front Microbiol / Commonality of Multidrug-Resistant Klebsiella pneumoniae ST3...
Frontiers in microbiology2019; 10; 1657; doi: 10.3389/fmicb.2019.01657

Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.

Abstract: Multidrug-resistant (MDR) is considered a major global concern by the World Health Organization. Evidence is growing on the importance of circulation of MDR bacterial populations between animals and humans. Horses have been shown to carry commensal isolates of this bacterial species and can act as human MDR bacteria reservoirs. In this study, we characterized an extended-spectrum β-lactamase (ESBL)-producing sequence type (ST) 348 isolate from a horse, an ST reported for the first time in an animal, using next-generation sequencing. We compared it with six other MDR ST348 human isolates previously identified in health-care facilities in Portugal using a core genome multi-locus sequence typing approach to evaluate a possible genetic link. The horse isolate was resistant to most of the antimicrobials tested, including 3rd generation cephalosporins, fluoroquinolones, and aminoglycosides, and presented several antimicrobial resistance genes, including . Twenty-one allele differences were found between the horse isolate and the most similar human isolate, suggesting a recent common ancestor. Other similarities were observed regarding the content on antimicrobial resistance genes, plasmid incompatibility groups, and capsular and somatic antigens. This study illustrates the relevance of the dissemination of MDR strains, and enhances that identification of these types of bacterial strains in both human and veterinary settings is of significant relevance in order to understand and implement combined control strategies for MDR bacteria in animals and humans.
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Publication Date: 2019-07-18 PubMed ID: 31379799PubMed Central: PMC6657530DOI: 10.3389/fmicb.2019.01657Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study examined multidrug-resistant Klebsiella pneumoniae in both horses and humans in Portugal, suggesting a genetic link between the strains found in each species. This research emphasizes the importance of understanding the propagation of these strains in both human and veterinary contexts.

About the Research

  • The study focuses on multidrug-resistant (MDR) Klebsiella pneumoniae, a type of bacteria that is of major global concern according to the World Health Organization.
  • The focal pull of the research is the interchange of these MDR bacteria between animals and humans. Special emphasis is given on the relationship between humans and horses specifically. Horses are known to host these bacterial species and can act as reservoirs for MDR bacteria that infect humans.

Methodology and Findings

  • The researchers analyzed an extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae sequence type (ST) 348 isolate from a horse. This is a particular strain of MDR Klebsiella pneumoniae, reported for the first time in an animal species. They used next-generation sequencing, a method of DNA sequencing, to conduct this analysis.
  • This was compared with six other MDR Klebsiella pneumoniae ST348 human isolates previously identified in healthcare facilities in Portugal. The comparison reveals a possible genetic link between the animal and human strains of the bacteria.
  • The horse isolate was found to be resistant to the majority of the antimicrobials tested, including 3rd generation cephalosporins, fluoroquinolones, and aminoglycosides, and had numerous antimicrobial resistance genes.
  • They unearthed a 21-allele difference between the horse and the most similar human isolate, suggesting that there could be a recent common ancestor between the two strains.

Relevance and Conclusion

  • The resistance to antimicrobials that the horse isolate exhibited, along with the antimicrobial resistance genes it possessed, point towards the serious implications of the dispersion of MDR strains among different species.
  • The study underscores the need for recognizing and identifying these bacterial strains in both humans and horses, given the evidence of their interspecies exchange.
  • It emphasizes the need for implementing combined control strategies for MDR bacteria in humans and animals. These measures are needed to better understand and hinder the dissemination of MDR bacterial strains.

Cite This Article

APA
Trigo da Roza F, Couto N, Carneiro C, Cunha E, Rosa T, Magalhães M, Tavares L, Novais Â, Peixe L, Rossen JW, Lamas LP, Oliveira M. (2019). Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal. Front Microbiol, 10, 1657. https://doi.org/10.3389/fmicb.2019.01657

Publication

Frontiers in microbiology
ISSN: 1664-302X
NlmUniqueID: 101548977
Country: Switzerland
Language: English
Volume: 10
Pages: 1657
PII: 1657

Researcher Affiliations

Trigo da Roza, Filipa
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Couto, Natacha
  • Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Carneiro, Carla
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Cunha, Eva
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Rosa, Teresa
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Magalhães, Mariana
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Tavares, Luís
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Novais, Ângela
  • UCIBIO/REQUIMTE, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
Peixe, Luísa
  • UCIBIO/REQUIMTE, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
Rossen, John W
  • Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Lamas, Luís P
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Oliveira, Manuela
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

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Citations

This article has been cited 9 times.
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