Comparative efficacy of moxidectin and ivermectin against hypobiotic and encysted cyathostomes and other equine parasites.
Abstract: Efficacies of moxidectin and ivermectin were compared in four groups of eight ponies with natural parasite infections: placebo (Control), oral moxidectin gel at 0.3 mg kg-1 of body weight (Mox 0.3), oral moxidectin gel at 0.4 mg kg-1 of body weight (Mox 0.4), and oral ivermectin paste at 0.2 mg kg-1 of body weight (Ivermectin). Fecal samples were taken 0 and 2 weeks after treatment. Animals were necropsied and worms were collected 2 weeks after treatment. Moxidectin and ivermectin showed similar efficacy (99%) against adult cyathostomes, Strongylus spp., Triodontophorus spp. and Habronema muscae. Both drugs were also more than 98% effective against luminal cyathostome and Oxyuris equi fourth stage larvae (L4). Neither drug was effective (0-10.1%) against hypobiotic early third stage cyathostome larvae (EL3). Moxidectin was moderately effective (62.6-79.1%) in removing encysted cyathostome late third stage larvae (LL3) and L4, whereas ivermectin was ineffective (0%) against these stages. By contrast, ivermectin was 95.4% effective against Gasterophilus spp. third instar stage, whereas moxidectin was only 0-20.4% effective.
Publication Date: 1994-05-01 PubMed ID: 8091622DOI: 10.1016/0304-4017(94)90020-5Google Scholar: Lookup
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- Clinical Trial
- Comparative Study
- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This research study compares the efficacies of two drugs, moxidectin and ivermectin, in treating certain internal parasites in ponies. It was found that both drugs were almost equally effective against adult cyathostomes and other parasites, but moxidectin was more effective against encysted cyathostome larvae, while ivermectin was more effective against Gasterophilus spp.
Methodology
- The researchers executed their comparative study using four groups of eight ponies, each naturally infected with parasites.
- The groups were defined as per their treatments: a placebo group (Control), a group treated with oral moxidectin gel at concentrations of 0.3 mg kg-1 of body weight (Mox 0.3), one with 0.4 mg kg-1 of body weight (Mox 0.4), and one treated with ivermectin paste at 0.2 mg kg-1 of body weight (Ivermectin).
- Fecal samples were collected initially and two weeks post-treatment from each pony to measure efficacy. All animals were euthanized for parasite collection two weeks after the treatment.
Results: General Efficacy
- Both moxidectin and ivermectin demonstrated an almost similar efficacy (99%) against adult cyathostomes, Strongylus spp., Triodontophorus spp. and Habronema muscae parasites.
- The two drugs were also more than 98% effective against luminal cyathostome and Oxyuris equi fourth-stage larvae (L4).
Results: Efficacy against Hypobiotic Early Third Stage Cyathostome Larvae
- Neither moxidectin nor ivermectin was effective against hypobiotic early third stage cyathostome larvae (EL3), with efficacy rates ranging between 0-10.1%.
Results: Efficacy against Encysted Cyathostome Late Third Stage Larvae
- Moxidectin was moderately effective (62.6-79.1%) in getting rid of encysted cyathostome late third-stage larvae (LL3) and L4.
- Contrastingly, ivermectin was completely ineffective (0%) against these stages.
Results: Efficacy against Gasterophilus spp. Third Instar Stage
- Ivermectin was 95.4% effective against the Gasterophilus spp. third instar stage, indicating its superior efficacy in this case.
- On the other hand, moxidectin only demonstrated 0-20.4% effectiveness against the Gasterophilus spp. third instar stage.
Cite This Article
APA
Xiao L, Herd RP, Majewski GA.
(1994).
Comparative efficacy of moxidectin and ivermectin against hypobiotic and encysted cyathostomes and other equine parasites.
Vet Parasitol, 53(1-2), 83-90.
https://doi.org/10.1016/0304-4017(94)90020-5 Publication
Researcher Affiliations
- Department of Veterinary Preventive Medicine, Ohio State University College of Veterinary Medicine, Columbus 43210.
MeSH Terms
- Animals
- Anthelmintics / therapeutic use
- Anti-Bacterial Agents / therapeutic use
- Feces / parasitology
- Female
- Horse Diseases / drug therapy
- Horses
- Intestinal Diseases, Parasitic / drug therapy
- Intestinal Diseases, Parasitic / veterinary
- Ivermectin / therapeutic use
- Macrolides
- Male
- Parasite Egg Count / veterinary
- Strongyle Infections, Equine / drug therapy
Citations
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