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Home / Equine Research Bank / Can Vet J / Comparative long-term efficacy of ivermectin and moxidectin ...
The Canadian veterinary journal = La revue veterinaire canadienne2009; 50(5); 486-490;

Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing.

Abstract: The impact of a late fall treatment on the spring rise of fecal egg counts was evaluated in a controlled study with Canadian horses treated with 2 different dewormers immediately after removal from pasture for winter housing. The horses were stabled until the end of the trial period. Seventeen weanlings, 20 yearlings, and 15 2-year-old horses located in Ontario, which were presumed to be naturally infected with cyathostomins after pasture grazing, were randomly allocated to either a group treated with 0.4 mg/kg of moxidectin and 2.5 mg/kg of praziquantel or a group treated with 0.2 mg/kg of ivermectin and 1.5 mg/kg of praziquantel. Three weeks after treatment, all strongyle fecal egg counts were reduced to zero for both treatment groups. However, at 5 months post-treatment, mean geometric fecal egg counts were statistically higher for the yearlings and 2-year-old horses treated with ivermectin than for the yearlings and 2-year-old horses treated with moxidectin (P < 0.0001). Efficacité comparative de l’ivermectine et de la moxidectine 5 mois après le traitement automnal de chevaux retirés du pâturage pour la durée de l’hiver canadien. L’impact sur l’augmentation printanière du comptage d’œufs fécaux d’un traitement automnal à la sortie du pâturage pour hivernement a été évalué dans une étude contrôlée avec des chevaux canadiens ayant reçu soit un gel oral contenant 2,0 % de moxidectine ou soit une pâte orale contenant 1,87 % d’ivermectine. Dix-sept poulains sevrés, 20 poulains d’un an et 15 poulains de 2 ans résidant dans une écurie localisée en Ontario, et présumés être infectés naturellement par des cyathostomes après une saison de pâture, furent répartis de façon aléatoire entre un groupe traité avec 0,4 mg/kg de moxidectine et 2,5 mg/kg de praziquantel et un groupe traité avec 0,2 mg/kg d’ivermectine et 1,5 mg/kg de praziquantel. Trois semaines après le traitement automnal, tous les comptages d’œufs fécaux furent réduits à zéro pour les deux groupes traités. Cependant, à 5 mois après le traitement, les comptages géométriques moyens des poulains âgés de un et deux ans furent statistiquement plus élevés pour ceux traités avec l’ivermectine que pour ceux traités avec la moxidectine (P < 0,0001). (Traduit par les auteurs)
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Publication Date: 2009-05-14 PubMed ID: 19436633PubMed Central: PMC2671870
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article explores the long-term effects of two deworming treatments, ivermectin and moxidectin, on horses moved to winter housing. They found that while both treatments initially reduced fecal egg counts to zero, five months later the counts were significantly higher in horses treated with ivermectin compared to those treated with moxidectin.

Research Context

  • The study investigated the long-term effect of two different deworming treatments on horses shifted to winter housing. The chosen dewormers for the study were ivermectin and moxidectin.
  • The purpose of the research was to evaluate how a late fall treatment could impact the spring rise in fecal egg counts, offering an indication of worm infestation. This was assessed specifically in Canadian horses following their removal from pasture for winter housing.

Research Methodology

  • The study sample was comprised of 17 weanlings, 20 yearlings, and 15 two-year-old horses in Ontario, Canada. These horses were chosen as they were presumed to be naturally infected with cyathostomins after grazing on pasture.
  • The horses were randomly divided into two groups. One group was treated with 0.4 mg/kg of moxidectin and 2.5 mg/kg of praziquantel while the second group was treated with 0.2 mg/kg of ivermectin and 1.5 mg/kg of praziquantel.
  • Three weeks after the deworming treatment, the fecal egg counts of all strongyles were evaluated and found to be reduced to zero in both groups.

Findings and Conclusion

  • Five months after the deworming treatment, a follow-up evaluation on the fecal egg counts was done. It revealed that the average geometric fecal egg counts were significantly higher in yearlings and two-year-old horses treated with ivermectin compared to those treated with moxidectin. The difference was statistically significant (P < 0.0001), suggesting that the latter may have a more prolonged effect in controlling fecal egg counts.
  • The findings indicate that while both ivermectin and moxidectin effectively reduced fecal egg counts to zero initially, moxidectin appears to have superior long-term efficacy in maintaining reduced fecal egg counts in horses shifted to winter housing.

Cite This Article

APA
Elsener J, Villeneuve A. (2009). Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing. Can Vet J, 50(5), 486-490.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 50
Issue: 5
Pages: 486-490

Researcher Affiliations

Elsener, Johanne
  • Wyeth Animal Health, 400 Michener Road, Guelph, Ontario, N1K 1E4. jelsener@wyeth.com
Villeneuve, Alain

    MeSH Terms

    • Age Factors
    • Animals
    • Antiparasitic Agents / pharmacology
    • Drug Combinations
    • Drug Resistance
    • Feces / parasitology
    • Female
    • Horses
    • Housing, Animal
    • Ivermectin / pharmacology
    • Macrolides / pharmacology
    • Male
    • Ontario
    • Parasite Egg Count / veterinary
    • Poaceae
    • Random Allocation
    • Seasons
    • Strongyle Infections, Equine / drug therapy
    • Strongyle Infections, Equine / parasitology
    • Strongyle Infections, Equine / prevention & control
    • Time Factors
    • Treatment Outcome

    References

    This article includes 41 references
    1. Bairden K, Brown SR, McGoldrick J, Parker LD, Talty PJ. Efficacy of moxidectin 2 percent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomins.. Vet Rec 2001;148:138–141.
      pubmed: 11271915
    2. Peregrine AS, McEwen B, Bienzle D, Koch TG, Weese JS. Larval cyathostominosis in horses in Ontario: An emerging disease?. Can Vet J 2006;47:80–82.
      pmc: PMC1316126pubmed: 16536234
    3. Mair TS. Outbreak of larval cyathostomiasis among a group of yearling and two-year-old horses.. Vet Rec 1994;135:598–600.
      pubmed: 7900244
    4. Lyons ET, Swerczek TW, Tolliver SC. A study of natural infections of encysted small strongyles in a horse herd in Kentucky.. Vet Med 1994:1146–1155.
    5. Slocombe JO, Coté JF, McMillan I. Effectiveness of oxybendazole against benzimidazole-resistant strongyles in horses.. Can Vet J 1989;30:663–665.
      pmc: PMC1681156pubmed: 17423395
    6. Slocombe JO, de Gannes RVG. Cyathostomins in horses in Canada resistant to pyrantel salts and effectively removed by moxidectin.. Vet Parasitol 2006;140:181–184.
      pubmed: 16682123
    7. Reinemeyer CR. Practical and theoretical consequences of larvicidal therapy.. Equine Pract 1998;20:10–13.
    8. Chapman MR, French DD, Taylor HW, Klei TR. One season of pasture exposure fails to induce a protective resistance to cyathostomins but increases numbers of hypobiotic third-stage larvae.. J Parasitol 2002;4:678–683.
      pubmed: 12197113
    9. Duncan JL. Field studies on the epidemiology of mixed strongyle infection in the horse.. Vet Rec 1974;94:337–345.
      pubmed: 4836097
    10. Genchi C, Malnati G, Carrara L. Aspetti epidemiologici di nematode gastrointestinalis degli animali al pascolo.. Clin Vet (Milano) 1978;101:175–184.
    11. Mirck MH. An investigation into the epidemiology of Strongylidae infection in the horse in the Netherlands.. Vet Q 1981;3:98–100.
      pubmed: 7245176
    12. Craig TM, Bowen JM, Ludwig KC. Transmission of equine cyathostomins (Strongylidae) in central Texas.. J Am Vet Med Assoc 1983;44:1867–1869.
      pubmed: 6638646
    13. Herd RP, Williardson KL, Gabel AA. Epidemiological approach to the control of horse strongyles.. Equine Vet J 1985;17:202–207.
      pubmed: 3841055
    14. Slocombe JO, Valenzuela J, Lake MC. Epidemiology of strongyles in ponies in Ontario.. Can J Vet Res 1987;51:470–474.
      pmc: PMC1255367pubmed: 3453266
    15. Slocombe JO, Coté JF. Effectiveness of an ivermectin liquid formulation given by nasogastric tube against strongyles in horses.. Can Vet J 1988;29:986–988.
      pmc: PMC1681057pubmed: 17423198
    16. Love S, Duncan JL. The development of naturally acquired cyathostomin infection in ponies.. Vet Parasitol 1992;44:127–142.
      pubmed: 1441184
    17. Eysker M, Boersema JH, Kooyman FNJ. The effect of ivermectin treatment against inhibited third stage, late third stage and fourth stage larvae and adult stages of the cyathostomins in Shetland ponies and spontaneous expulsion of these helminthes.. Vet Parasitol 1992;42:295–302.
      pubmed: 1496789
    18. Klei TR, Chapman MR, French DD, Taylor HW. Evaluation of ivermectin at an elevated dose against encysted cyathostomin larvae.. Vet Parasitol 1993;47:99–106.
      pubmed: 8493773
    19. Xiao L, Herd RP, Majewski GA. Comparative efficacy of moxidectin and ivermectin against hypobiotic and encysted cyathostomins and other equine parasites.. Vet Parasitol 1994;53:83–90.
      pubmed: 8091622
    20. Monahan CM, Chapman MR, Taylor HW, French DD, Klei TR. Comparison of moxidectin oral gel and ivermectin oral paste against a spectrum of internal parasites of ponies with special attention to encysted cyathostomin larvae.. Vet Parasitol 1996;63:225–235.
      pubmed: 8966989
    21. Bello TR, Laningham JET. A controlled trial evaluation of three oral dosages of moxidectin against equine parasites.. J Equine Vet Sci 1994;14:483–488.
    22. Monahan CM, Chapman MR, Taylor HW, French DD, Klei TR. Dose titration of moxidectin oral gel against gastrointestinal parasites of ponies.. Vet Parasitol 1995;59:241–248.
      pubmed: 8533282
    23. Eysker M, Boersema JH, Grinwis GCM, Kooyman FNJ, Poot J. Controlled dose confirmation study of a 2% moxidectin equine gel against equine internal parasites in the Netherlands.. Vet Parasitol 1997;70:165–173.
      pubmed: 9195720
    24. Bairden K, Davies HS, Gibson NR, Hood AJO, Parker LD. Efficacy of moxidectin 2 percent gel against cyathostomins, particularly third-stage inhibited larvae, in horses.. Vet Rec 2006;158:766–768.
      pubmed: 16751314
    25. Steinbach T, Bauer C, Sasse H. Small strongyle infection: Consequences of larvicidal treatment of horses with fenbendazole and moxidectin.. Vet Parasitol 2006;139:115–131.
      pubmed: 16675126
    26. Jacobs DE, Hutchinson MJ, Parker L, Gibbons LM. Equine cyathostomin infection: Suppression of fecal egg output with moxidectin.. Vet Rec 1995;137:545.
      pubmed: 8592818
    27. Taylor SM, Kenny J. Comparison of moxidectin with ivermectin and pyrantel embonate for reduction of faecal egg counts in horses.. Vet Rec 1995;137:516–518.
      pubmed: 8588278
    28. Corba J, Praslicka J, Varady M, Andrasko H, Holakovsky P. Efficacy of moxidectin 2% equine gel and Eqvalan 1% paste against naturally acquired internal parasite infections in horses.. Helminthologia 1995;32:215–218.
    29. Demeulenaere D, Vercruysse J, Dorny P, Claerebout E. Comparative studies of ivermectin and moxidectin in the control of naturally acquired cyathostomin infections in horses.. Vet Rec 1997;141:383–386.
      pubmed: 9364706
    30. DiPietro JA, Hutchens DE, Lock TF. Clinical trial of moxidectin oral gel in horses.. Vet Parasitol 1997;72:167–177.
      pubmed: 9404843
    31. Rolfe PF, Dawson KL, Glass J. Efficacy of moxidectin and other anthelmintics against small strongyles in horses.. Aust Vet J 1998;76:1–3.
      pubmed: 9631701
    32. Martin-Downum K, Yazwinski T, Yucker C, Fincher M, Ralph J, Hamilton J. Cyathostomin fecal egg count trends in horses treated with moxidectin, ivermectin or fenbendazole.. Vet Parasitol 2001;101:75–79.
      pubmed: 11587835
    33. Holm-Martin M, Levot GW, Dawson KL. Control of endoparasites in horses with a gel containing moxidectin and praziquantel.. Vet Rec 2005;156:835–838.
      pubmed: 15980136
    34. Cox DD, Todd AC. Survey of gastrointes¬tinal parasitism in Wisconsin dairy cattle.. J Am Vet Med Assoc 1962;141:706–709.
      pubmed: 13881890
    35. Uhlinger CA. Equine small strongyles: Epidemiology, pathology, and control.. Compend Contin Educ Pract Vet 1991;13:863–869.
    36. Matthee S, McGeoch MA. Helminths in horses: Use of selective treatment for the control of strongyles.. J S Afr Vet Assoc 2004;75:129–136.
      pubmed: 15628805
    37. Hamlen Gomez H, Georgi JR. Equine helminth infections: Control by selective chemotherapy.. Equine Vet J 1991;23:198–200.
      pubmed: 1884701
    38. Duncan JL, Love S. Preliminary observations on an alternative strategy for the control of horse strongyles.. Equine Vet J 1991;23:226–228.
      pubmed: 1909236
    39. Krecek RC, Guthrie AJ, van Nieuwenhuizen LC, Booth LM. A comparison between the effects of conventional and selective antiparasitic treatments on nematode parasites of horses from two management schemes.. J S Afr Vet Assoc 1994;65:97–100.
      pubmed: 7595925
    40. Little D, Flowers JR, Hammerberg BH, Gardner SY. Management of drug-resistant cyathostominosis on a breeding farm in central North Caroline.. Equine Vet J 2003;35:246–251.
      pubmed: 12755426
    41. von Samson-Himmelstjerna G, Fritzen B, Demeler J. Cases of reduced cyathostomin egg-reappearance period and failure of Parascaris equorum count reuction following ivermectin treatment as well as survey on pyrantel efficacy on German horse farms.. Vet Parasitol 2007;144:74–80.
      pubmed: 17112667

    Citations

    This article has been cited 2 times.
    1. Ramalho Sousa S, Anastácio S, Nóvoa M, Paz-Silva A, Madeira de Carvalho LM. Gastrointestinal Parasitism in Miranda Donkeys: Epidemiology and Selective Control of Strongyles Infection in the Northeast of Portugal. Animals (Basel) 2021 Jan 11;11(1).
      doi: 10.3390/ani11010155pubmed: 33440886google scholar: lookup
    2. Elsener J, Villeneuve A. Does examination of fecal samples 24 hours after cestocide treatment increase the sensitivity of Anoplocephala spp. detection in naturally infected horses?. Can Vet J 2011 Feb;52(2):158-61.
      pubmed: 21532821
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