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The Canadian veterinary journal = La revue veterinaire canadienne2009; 50(5); 486-490;

Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing.

Abstract: The impact of a late fall treatment on the spring rise of fecal egg counts was evaluated in a controlled study with Canadian horses treated with 2 different dewormers immediately after removal from pasture for winter housing. The horses were stabled until the end of the trial period. Seventeen weanlings, 20 yearlings, and 15 2-year-old horses located in Ontario, which were presumed to be naturally infected with cyathostomins after pasture grazing, were randomly allocated to either a group treated with 0.4 mg/kg of moxidectin and 2.5 mg/kg of praziquantel or a group treated with 0.2 mg/kg of ivermectin and 1.5 mg/kg of praziquantel. Three weeks after treatment, all strongyle fecal egg counts were reduced to zero for both treatment groups. However, at 5 months post-treatment, mean geometric fecal egg counts were statistically higher for the yearlings and 2-year-old horses treated with ivermectin than for the yearlings and 2-year-old horses treated with moxidectin (P < 0.0001). Efficacité comparative de l’ivermectine et de la moxidectine 5 mois après le traitement automnal de chevaux retirés du pâturage pour la durée de l’hiver canadien. L’impact sur l’augmentation printanière du comptage d’œufs fécaux d’un traitement automnal à la sortie du pâturage pour hivernement a été évalué dans une étude contrôlée avec des chevaux canadiens ayant reçu soit un gel oral contenant 2,0 % de moxidectine ou soit une pâte orale contenant 1,87 % d’ivermectine. Dix-sept poulains sevrés, 20 poulains d’un an et 15 poulains de 2 ans résidant dans une écurie localisée en Ontario, et présumés être infectés naturellement par des cyathostomes après une saison de pâture, furent répartis de façon aléatoire entre un groupe traité avec 0,4 mg/kg de moxidectine et 2,5 mg/kg de praziquantel et un groupe traité avec 0,2 mg/kg d’ivermectine et 1,5 mg/kg de praziquantel. Trois semaines après le traitement automnal, tous les comptages d’œufs fécaux furent réduits à zéro pour les deux groupes traités. Cependant, à 5 mois après le traitement, les comptages géométriques moyens des poulains âgés de un et deux ans furent statistiquement plus élevés pour ceux traités avec l’ivermectine que pour ceux traités avec la moxidectine (P < 0,0001). (Traduit par les auteurs)
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Publication Date: 2009-05-14 PubMed ID: 19436633PubMed Central: PMC2671870
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article explores the long-term effects of two deworming treatments, ivermectin and moxidectin, on horses moved to winter housing. They found that while both treatments initially reduced fecal egg counts to zero, five months later the counts were significantly higher in horses treated with ivermectin compared to those treated with moxidectin.

Research Context

  • The study investigated the long-term effect of two different deworming treatments on horses shifted to winter housing. The chosen dewormers for the study were ivermectin and moxidectin.
  • The purpose of the research was to evaluate how a late fall treatment could impact the spring rise in fecal egg counts, offering an indication of worm infestation. This was assessed specifically in Canadian horses following their removal from pasture for winter housing.

Research Methodology

  • The study sample was comprised of 17 weanlings, 20 yearlings, and 15 two-year-old horses in Ontario, Canada. These horses were chosen as they were presumed to be naturally infected with cyathostomins after grazing on pasture.
  • The horses were randomly divided into two groups. One group was treated with 0.4 mg/kg of moxidectin and 2.5 mg/kg of praziquantel while the second group was treated with 0.2 mg/kg of ivermectin and 1.5 mg/kg of praziquantel.
  • Three weeks after the deworming treatment, the fecal egg counts of all strongyles were evaluated and found to be reduced to zero in both groups.

Findings and Conclusion

  • Five months after the deworming treatment, a follow-up evaluation on the fecal egg counts was done. It revealed that the average geometric fecal egg counts were significantly higher in yearlings and two-year-old horses treated with ivermectin compared to those treated with moxidectin. The difference was statistically significant (P < 0.0001), suggesting that the latter may have a more prolonged effect in controlling fecal egg counts.
  • The findings indicate that while both ivermectin and moxidectin effectively reduced fecal egg counts to zero initially, moxidectin appears to have superior long-term efficacy in maintaining reduced fecal egg counts in horses shifted to winter housing.

Cite This Article

APA
Elsener J, Villeneuve A. (2009). Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing. Can Vet J, 50(5), 486-490.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 50
Issue: 5
Pages: 486-490

Researcher Affiliations

Elsener, Johanne
  • Wyeth Animal Health, 400 Michener Road, Guelph, Ontario, N1K 1E4. jelsener@wyeth.com
Villeneuve, Alain

    MeSH Terms

    • Age Factors
    • Animals
    • Antiparasitic Agents / pharmacology
    • Drug Combinations
    • Drug Resistance
    • Feces / parasitology
    • Female
    • Horses
    • Housing, Animal
    • Ivermectin / pharmacology
    • Macrolides / pharmacology
    • Male
    • Ontario
    • Parasite Egg Count / veterinary
    • Poaceae
    • Random Allocation
    • Seasons
    • Strongyle Infections, Equine / drug therapy
    • Strongyle Infections, Equine / parasitology
    • Strongyle Infections, Equine / prevention & control
    • Time Factors
    • Treatment Outcome

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    Citations

    This article has been cited 2 times.
    1. Ramalho Sousa S, Anastácio S, Nóvoa M, Paz-Silva A, Madeira de Carvalho LM. Gastrointestinal Parasitism in Miranda Donkeys: Epidemiology and Selective Control of Strongyles Infection in the Northeast of Portugal. Animals (Basel) 2021 Jan 11;11(1).
      doi: 10.3390/ani11010155pubmed: 33440886google scholar: lookup
    2. Elsener J, Villeneuve A. Does examination of fecal samples 24 hours after cestocide treatment increase the sensitivity of Anoplocephala spp. detection in naturally infected horses?. Can Vet J 2011 Feb;52(2):158-61.
      pubmed: 21532821
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