Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses.
Abstract: Bradycardia may be implicated as a cause of cardiovascular instability during anaesthesia. Objective: Hyoscine would induce positive chronotropism of shorter duration than atropine, without adversely impairing intestinal motility in detomidine sedated horses. Methods: Ten minutes after detomidine (0.02 mg/kg bwt, i.v.), physiological saline (control), atropine (0.02 mg/kg bwt) or hyoscine (0.2 mg/kg bwt) were randomly administered i.v. to 6 horses, allowing one week intervals between treatments. Investigators blinded to the treatments monitored cardiopulmonary data and intestinal auscultation for 90 min and 24 h after detomidine, respectively. Gastrointestinal transit was assessed for 96 h via chromium detection in dry faeces. Results: Detomidine significantly decreased heart rate (HR) and cardiac index (CI) from baseline for 30 and 60 min, respectively (control). Mean ± s.d. HR increased significantly 5 min after atropine (79 ± 5 beats/min) and hyoscine (75 ± 8 beats/min). After this time, HR was significantly higher after atropine in comparison to other treatments, while hyoscine resulted in intermediate values (lower than atropine but higher than controls). Hyoscine and atropine resulted in significantly higher CI than controls for 5 and 20 min, respectively; but this effect coincided with significant hypertension (mean arterial pressures >180 mmHg). Auscultation scores decreased from baseline in all treatments. Time to return to auscultation scores ≥12 (medians) did not differ between hyoscine (4 h) and controls (4 h) but atropine resulted in significantly longer time (10 h). Atropine induced colic in one horse. Gastrointestinal transit times did not differ between treatments. Conclusions: Hyoscine is a shorter acting positive chronotropic agent than atropine, but does not potentiate the impairment in intestinal motility induced by detomidine. Because of severe hypertension, routine use of anticholinergics combined with detomidine is not recommended. Conclusions: Hyoscine may represent an alternative to atropine for treating bradycardia.
© 2010 EVJ Ltd.
Publication Date: 2010-09-14 PubMed ID: 21492211DOI: 10.1111/j.2042-3306.2010.00165.xGoogle Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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The research article discusses a comparative study between hyoscine and atropine in countering bradycardia in horses sedated with detomidine. The study found that hyoscine is shorter-acting yet doesn’t enhance the detomidine-induced intestinal impairment like atropine; therefore, it might offer a better alternative in treating bradycardia.
Study Objective and Methodology
- The study aimed to determine whether hyoscine could increase heart rate (a positive chronotropic effect) for a shorter period than atropine without damaging intestinal motility in detomidine-sedated horses.
- The investigation involved six horses. Ten minutes after injecting detomidine, the researchers administered a physiological saline (as a control), atropine, or hyoscine. They gave each treatment a week apart, observing the heart and pulmonary data and doing intestinal auscultation for 90 minutes and 24 hours after sedation, respectively.
- They also examined gastrointestinal transit by tracking chromium within the horses’ feces for 96 hours.
Study Findings
- Results showed that detomidine significantly decreased the heart rate (HR) and cardiac index for 30 and 60 minutes, respectively. Both atropine and hyoscine caused a notable rise in HR 5 minutes after administration, but HR remained significantly higher with atropine compared to other treatments after that time. However, hyoscine resulted in intermediate values i.e., lower than atropine but higher than control.
- Hyoscine and atropine increased the cardiac index significantly for 5 and 20 minutes, respectively, than the controls. However, this effect correlated with severe hypertension.
- Auscultation scores decreased from the baseline across all treatments. The time to return to auscultation scores was shorter for hyoscine and control (4 hours) than atropine (10 hours), which led to colic in one horse.
- In terms of gastrointestinal transit times, there were no significant differences among the treatments.
Conclusions
- The researchers found hyoscine to be a shorter-acting positive chronotropic agent than atropine and doesn’t amplify detomidine-induced motility impairment, making it a potentially better alternative for treating bradycardia.
- However, due to severe hypertension, they do not recommend using anticholinergics like hyoscine and atropine with detomidine regularly.
Cite This Article
APA
Pimenta EL, Teixeira Neto FJ, Sá PA, Pignaton W, Garofalo NA.
(2010).
Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses.
Equine Vet J, 43(3), 332-340.
https://doi.org/10.1111/j.2042-3306.2010.00165.x Publication
Researcher Affiliations
- Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, São Paulo, Brazil.
MeSH Terms
- Animals
- Anti-Arrhythmia Agents / therapeutic use
- Atropine / therapeutic use
- Bradycardia / chemically induced
- Bradycardia / drug therapy
- Bradycardia / veterinary
- Butylscopolammonium Bromide / therapeutic use
- Cross-Over Studies
- Female
- Hypnotics and Sedatives / adverse effects
- Imidazoles / adverse effects
- Male
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