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Home / Equine Research Bank / Vet Rec / Comparing the anti-nociceptive, sedative and clinicophysiolo...
The Veterinary record2022; 192(10); e2479; doi: 10.1002/vetr.2479

Comparing the anti-nociceptive, sedative and clinicophysiological effects of epidural detomidine, detomidine-lidocaine and lidocaine in donkeys.

Abstract: Epidural analgesia using the alpha-2 agonist detomidine (DE), alone or in combination with lidocaine (LD), is frequently employed for standing surgical procedures in horses, but its use has not been evaluated in donkeys. Methods: In a randomised controlled prospective trial, 24 healthy adult donkeys were assigned to four groups (n = 6), each receiving 40 μg/kg of DE, 0.22 mg/kg of LD, combined DE and LD (DELD) or 0.9% sterile normal saline epidurally. After epidural injection of each treatment, the onset, degree and duration of sedation and anatomical extension of anti-nociception were observed. Results: DE and DELD treatments resulted in complete bilateral analgesia with loss of sensation in the tail, perineum, inguinal area, chest and the caudal aspect of the upper pelvic limb, and extended distally to the dorsal metatarsal area. DE and DELD resulted in a significantly (p < 0.05) longer duration of anti-nociception (110 ± 15.4 min and 141.6 ± 14.7 min, respectively) than LD (75.8 ± 4.9 min). The DELD duration of sedation was significantly (p < 0.05) longer than the DE duration (118.3 ± 19.4 min and 108.3 ± 7.5 min, respectively). Conclusions: The current study's main limitation is using only one dose of DE. Conclusions: DE and DELD produced a very effective, safe and acceptable sedative and analgesic effect in the perineal and inguinal regions of donkeys.
© 2022 British Veterinary Association.
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Publication Date: 2022-12-21 PubMed ID: 36544432DOI: 10.1002/vetr.2479Google Scholar: Lookup
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  • Randomized Controlled Trial
  • Veterinary
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article looks into the effects of using epidural analgesia – with the drugs detomidine and lidocaine, alone and combined – in sedating donkeys and numbing them to pain. This medication approach is frequently used for standing surgical procedures in horses, but its application has not been widely explored in donkeys before.

Research Design and Methodology

  • A randomized controlled prospective trial was utilized for the study which included 24 healthy adult donkeys. The donkeys were separated into four groups (each containing 6 donkeys) with each group receiving different medication: detomidine (DE), lidocaine (LD), a combination of DE and LD (DELD), or a regulated saline solution epidurally (injection into the spinal canal).
  • The researchers then observed the effects of these different treatments, looking at the onset, degree, and duration of sedation, as well as the scale of anti-pain (anti-nociception) effect in the donkeys.

Results of the Research

  • The DE and DELD treatments resulted in a significant loss of sensation in multiple regions such as the tail, perineum, chest, inguinal area and even on the limbs of the donkeys. This implies that the substances were effective in bringing about total bilateral analgesia or loss of sensation to pain.
  • Additionally, the DE and DELD treatments showed significantly longer durations of anti-nociception (110 minutes and 141.6 minutes, respectively) compared to LD, which lasted for roughly 75.8 minutes.
  • The duration of sedation for the combined drug (DELD) was notably longer than when DE was used alone (118.3 minutes versus 108.3 minutes).

Conclusion and Limitation of the Research

  • One of the main limitations of the study is that it used only one dose of DE, so the effects of different doses aren’t explored.
  • The research concluded that the use of DE and DELD produced a safe and effective sedative and pain-numbing effect on donkeys, especially in the perineal and inguinal regions.

Cite This Article

APA
Marzok M, Almubarak AI, Kandeel M, El-Khodery S. (2022). Comparing the anti-nociceptive, sedative and clinicophysiological effects of epidural detomidine, detomidine-lidocaine and lidocaine in donkeys. Vet Rec, 192(10), e2479. https://doi.org/10.1002/vetr.2479

Publication

The Veterinary record
ISSN: 2042-7670
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 192
Issue: 10
Pages: e2479

Researcher Affiliations

Marzok, Mohamed
  • Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
  • Department of Surgery, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
Almubarak, Adel I
  • Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Kandeel, Mahmoud
  • Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
  • Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
El-Khodery, Sabry
  • Department of Internal Medicine, Infectious Diseases and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Manosura, Egypt.

MeSH Terms

  • Horses
  • Animals
  • Equidae / physiology
  • Hypnotics and Sedatives
  • Lidocaine
  • Prospective Studies
  • Analgesia, Epidural / veterinary

Grant Funding

  • AN000422 / Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia

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