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Home / Equine Research Bank / Front Vet Sci / Comparison of Effects of an Endotracheal Tube or Facemask on...
Frontiers in veterinary science2022; 9; 895268; doi: 10.3389/fvets.2022.895268

Comparison of Effects of an Endotracheal Tube or Facemask on Breathing Pattern and Distribution of Ventilation in Anesthetized Horses.

Abstract: Equine respiratory physiology might be influenced by the presence of an endotracheal tube (ETT). This experimental, randomized cross-over study aimed to compare breathing pattern (BrP) and ventilation distribution in anesthetized horses spontaneously breathing room air via ETT or facemask (MASK). Six healthy adult horses were anesthetized with total intravenous anesthesia (TIVA; xylazine, ketamine, guaiphenesin), breathing spontaneously in right lateral recumbency, and randomly assigned to ETT or MASK for 30 min, followed by the other treatment for an additional 30 min. During a second anesthesia 1 month later, the treatment order was inversed. Electrical impedance tomography (EIT) using a thoracic electrode belt, spirometry, volumetric capnography, esophageal pressure difference (ΔPoes), venous admixture, and laryngoscopy data were recorded over 2 min every 15 min. Breaths were classified as normal or alternate (sigh or ) according to the EIT impedance curve. A mixed linear model was used to test the effect of treatment on continuous outcomes. Cochran-Mantel-Haenszel analysis was used to test for associations between global BrP and treatment. Global BrP was associated with treatment ( = 0.012) with more alternate breaths during ETT. The center of ventilation right-to-left (CoV) showed more ventilation in the non-dependent lung during ETT ( = 0.025). The I:E ratio ( = 0.017) and ΔPoes ( < 0.001) were smaller, and peak expiratory flow ( = 0.009) and physiologic dead space ( = 0.034) were larger with ETT. The presence of an ETT alters BrP and shifts ventilation toward the non-dependent lung in spontaneously breathing horses anesthetized with TIVA.
Copyright © 2022 Moreno-Martinez, Byrne, Raisis, Waldmann, Hosgood and Mosing.
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Publication Date: 2022-06-09 PubMed ID: 35836499PubMed Central: PMC9275410DOI: 10.3389/fvets.2022.895268Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research aimed to compare how an endotracheal tube (ETT) and a facemask influence breathing patterns and ventilation distribution in anesthetized horses. The study found that an ETT alters breathing patterns and shifts ventilation towards the non-dependent lung in spontaneously breathing horses anesthetized with total intravenous anesthesia.

Methods and Procedures

  • The participants in this experimental, randomized cross-over study were six healthy adult horses.
  • Horses were anesthetized using total intravenous anesthesia (xylazine, ketamine, guaiphenesin), resulting in spontaneous breathing.
  • After being put into a right lateral recumbency position, each horse was randomly assigned to use an ETT or MASK for 30 minutes. This procedure was followed by using the other treatment for an additional 30 minutes.
  • To reverse the treatment order, a second anesthesia was performed a month later.
  • Parameters such as electrical impedance tomography (EIT) through a thoracic electrode belt, spirometry, volumetric capnography, esophageal pressure difference (ΔPoes), venous admixture, and laryngoscopy data were recorded over 2-minute intervals every 15 minutes.
  • By examining the EIT impedance curve, breaths were classified as normal or alternate (sigh or ).
  • Statistical techniques including a mixed linear model, and Cochran-Mantel-Haenszel analysis were used to analyze the effect of treatment on continuous outcomes and the association between breath patterns and treatment.

Results and Findings

  • The study found that the method of ventilation (ETT or MASK) significantly impacted the horse’s breathing pattern. (p=0.012)
  • More alternate breaths were on record during ETT, revealing a variation in the breathing pattern.
  • ETT also had a notable effect on the distribution of ventilation. The center of ventilation right-to-left (CoV) showed more ventilation concentrating in the non-dependent lung during ETT. (p=0.025)
  • Indices of mechanical ventilation also varied: The I:E ratio (p=0.017) and ΔPoes (p<0.001) were smaller, and peak expiratory flow (p=0.009) and physiological dead space (p=0.034) turned out to be larger with ETT when compared to the facemask.

Conclusion

  • The research concluded that the application of an endotracheal tube significantly alters the breathing pattern and shifts ventilation towards the non-dependent lung in spontaneously breathing horses under total intravenous anesthesia.
  • This infers that the choice of mechanical ventilation technique can have critical implications for respiratory physiology in anesthetized horses.

Cite This Article

APA
Moreno-Martinez F, Byrne D, Raisis A, Waldmann AD, Hosgood G, Mosing M. (2022). Comparison of Effects of an Endotracheal Tube or Facemask on Breathing Pattern and Distribution of Ventilation in Anesthetized Horses. Front Vet Sci, 9, 895268. https://doi.org/10.3389/fvets.2022.895268

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 9
Pages: 895268
PII: 895268

Researcher Affiliations

Moreno-Martinez, Fernando
  • College of Veterinary Medicine, Murdoch University, Perth, WA, Australia.
Byrne, David
  • College of Veterinary Medicine, Murdoch University, Perth, WA, Australia.
Raisis, Anthea
  • College of Veterinary Medicine, Murdoch University, Perth, WA, Australia.
Waldmann, Andreas D
  • Department of Anaesthesiology and Intensive Care Medicine, Rostock University Medical Centre, Rostock, Germany.
Hosgood, Giselle
  • College of Veterinary Medicine, Murdoch University, Perth, WA, Australia.
Mosing, Martina
  • College of Veterinary Medicine, Murdoch University, Perth, WA, Australia.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

This article includes 40 references
  1. AMOROSO EC, SCOTT P, WILLIAMS KG. THE PATTERN OF EXTERNAL RESPIRATION IN THE UNANAESTHETIZED ANIMAL.. Proc R Soc Lond B Biol Sci 1964 Jan 14;159:325-47.
    doi: 10.1098/rspb.1964.0006pubmed: 14114168google scholar: lookup
  2. Koterba AM, Kosch PC, Beech J, Whitlock T. Breathing strategy of the adult horse (Equus caballus) at rest.. J Appl Physiol (1985) 1988 Jan;64(1):337-46.
    doi: 10.1152/jappl.1988.64.1.337pubmed: 3356653google scholar: lookup
  3. Young S. Laryngeal closure during expiration in anaesthetised ponies. J Assoc Vet Anaesth Great Britain Ireland (1989) 16:24–6.
    doi: 10.1111/j.1467-2995.1989.tb00064.xgoogle scholar: lookup
  4. Mosing M, Waldmann AD, MacFarlane P, Iff S, Auer U, Bohm SH, Bettschart-Wolfensberger R, Bardell D. Horses Auto-Recruit Their Lungs by Inspiratory Breath Holding Following Recovery from General Anaesthesia.. PLoS One 2016;11(6):e0158080.
    doi: 10.1371/journal.pone.0158080pmc: PMC4917253pubmed: 27331910google scholar: lookup
  5. Jones S, Franklin S, Martin C, Steel C. Complete upper airway collapse and apnoea during tethered swimming in horses.. Equine Vet J 2020 May;52(3):352-358.
    doi: 10.1111/evj.13177pubmed: 31495963google scholar: lookup
  6. Steffey EP, Hodgson DS, Dunlop CI, Miller MF, Woliner MJ, Heath RB, Grandy J. Cardiopulmonary function during 5 hours of constant-dose isoflurane in laterally recumbent, spontaneously breathing horses.. J Vet Pharmacol Ther 1987 Dec;10(4):290-7.
    doi: 10.1111/j.1365-2885.1987.tb00104.xpubmed: 3437493google scholar: lookup
  7. Kowalczyk L, Steblaj B, Schauvliege S, Schramel JP, Pavlidou K, Savvas I, Duchateau L, Gasthuys F, Moens Y. Comparison of respiratory function during TIVA and isoflurane anaesthesia in ponies Part II: breathing patterns and transdiaphragmatic pressure.. Vet Anaesth Analg 2014 Nov;41(6):592-601.
    doi: 10.1111/vaa.12151pubmed: 24986481google scholar: lookup
  8. Tomasic M, Mann LS, Soma LR. Effects of sedation, anesthesia, and endotracheal intubation on respiratory mechanics in adult horses.. Am J Vet Res 1997 Jun;58(6):641-6.
    pubmed: 9185973
  9. Mortola JP. How to breathe? Respiratory mechanics and breathing pattern.. Respir Physiol Neurobiol 2019 Mar;261:48-54.
    doi: 10.1016/j.resp.2018.12.005pubmed: 30605732google scholar: lookup
  10. Frerichs I, Amato MB, van Kaam AH, Tingay DG, Zhao Z, Grychtol B, Bodenstein M, Gagnon H, Böhm SH, Teschner E, Stenqvist O, Mauri T, Torsani V, Camporota L, Schibler A, Wolf GK, Gommers D, Leonhardt S, Adler A. Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the TRanslational EIT developmeNt stuDy group.. Thorax 2017 Jan;72(1):83-93.
    doi: 10.1136/thoraxjnl-2016-208357pmc: PMC5329047pubmed: 27596161google scholar: lookup
  11. Ambrisko TD, Schramel JP, Adler A, Kutasi O, Makra Z, Moens YP. Assessment of distribution of ventilation by electrical impedance tomography in standing horses.. Physiol Meas 2016 Feb;37(2):175-86.
    doi: 10.1088/0967-3334/37/2/175pubmed: 26711858google scholar: lookup
  12. Mosing M, Marly-Voquer C, MacFarlane P, Bardell D, Böhm SH, Bettschart-Wolfensberger R, Waldmann AD. Regional distribution of ventilation in horses in dorsal recumbency during spontaneous and mechanical ventilation assessed by electrical impedance tomography: a case series.. Vet Anaesth Analg 2017 Jan;44(1):127-132.
    doi: 10.1111/vaa.12405pubmed: 27483208google scholar: lookup
  13. Brabant O, Byrne D, Sacks M, Moreno Martinez F, Raisis A, Araos J. Thoracic electrical impedance tomography- the 2022 veterinary guidelines statement. (2022).
  14. Chelopo ND, Buss PE, Miller MA, Zeiler GE. Cardiopulmonary responses of free-ranging African elephant (Loxodonta africana) bulls immobilized with a thiafentanil-azaperone combination.. Vet Anaesth Analg 2022 May;49(3):291-298.
    pubmed: 35370092doi: 10.1016/j.vaa.2021.08.050google scholar: lookup
  15. Schramel JP, Wimmer K, Ambrisko TD, Moens YP. A novel flow partition device for spirometry during large animal anaesthesia.. Vet Anaesth Analg 2014 Mar;41(2):191-5.
    doi: 10.1111/vaa.12099pubmed: 24224723google scholar: lookup
  16. Ukere A, März A, Wodack KH, Trepte CJ, Haese A, Waldmann AD, Böhm SH, Reuter DA. Perioperative assessment of regional ventilation during changing body positions and ventilation conditions by electrical impedance tomography.. Br J Anaesth 2016 Aug;117(2):228-35.
    doi: 10.1093/bja/aew188pubmed: 27440635google scholar: lookup
  17. Brabant O, Crivellari B, Hosgood G, Raisis A, Waldmann AD, Auer U, Adler A, Smart L, Laurence M, Mosing M. Effects of PEEP on the relationship between tidal volume and total impedance change measured via electrical impedance tomography (EIT).. J Clin Monit Comput 2022 Apr;36(2):325-334.
    doi: 10.1007/s10877-021-00651-xpmc: PMC7829490pubmed: 33492490google scholar: lookup
  18. Crivellari B, Raisis A, Hosgood G, Waldmann AD, Murphy D, Mosing M. Use of Electrical Impedance Tomography (EIT) to Estimate Tidal Volume in Anaesthetized Horses Undergoing Elective Surgery.. Animals (Basel) 2021 May 10;11(5).
    doi: 10.3390/ani11051350pmc: PMC8151473pubmed: 34068514google scholar: lookup
  19. Tusman G, Sipmann FS, Borges JB, Hedenstierna G, Bohm SH. Validation of Bohr dead space measured by volumetric capnography.. Intensive Care Med 2011 May;37(5):870-4.
    doi: 10.1007/s00134-011-2164-xpubmed: 21359609google scholar: lookup
  20. Smale K, Anderson LS, Butler PJ. An algorithm to describe the oxygen equilibrium curve for the thoroughbred racehorse.. Equine Vet J 1994 Nov;26(6):500-2.
    doi: 10.1111/j.2042-3306.1994.tb04058.xpubmed: 7889927google scholar: lookup
  21. Berggren SM. The oxygen deficit of arterial blood caused by non-ventilated parts of the lung. Acta Physiol Scand (1942) 4:4–9.
    doi: 10.1111/j.1365-201X.1942.tb11004.xgoogle scholar: lookup
  22. Feldman JL, Del Negro CA, Gray PA. Understanding the rhythm of breathing: so near, yet so far.. Annu Rev Physiol 2013;75:423-52.
    doi: 10.1146/annurev-physiol-040510-130049pmc: PMC3671763pubmed: 23121137google scholar: lookup
  23. Ewart SL. Overview of respiratory function: ventilation of the lungs. In: Klein B. editor. Cunningham's Textbook of Veterinary Physiology. 6th ed. Amsterdam: Elsevier; (2020).
  24. Bartlett D Jr. Origin and regulation of spontaneous deep breaths.. Respir Physiol 1971 Jun;12(2):230-8.
    doi: 10.1016/0034-5687(71)90055-7pubmed: 5568463google scholar: lookup
  25. Li P, Janczewski WA, Yackle K, Kam K, Pagliardini S, Krasnow MA, Feldman JL. The peptidergic control circuit for sighing.. Nature 2016 Feb 18;530(7590):293-297.
    doi: 10.1038/nature16964pmc: PMC4852886pubmed: 26855425google scholar: lookup
  26. Boggs DF, Colby C, Williams BR Jr, Kilgore DL Jr. Chemosensitivity and breathing pattern regulation of the coatimundi and woodchuck.. Respir Physiol 1992 Aug;89(2):157-67.
    doi: 10.1016/0034-5687(92)90047-Zpubmed: 1439298google scholar: lookup
  27. Eichenwald EC, Ungarelli RA, Stark AR. Hypercapnia increases expiratory braking in preterm infants.. J Appl Physiol (1985) 1993 Dec;75(6):2665-70.
    doi: 10.1152/jappl.1993.75.6.2665pubmed: 8125887google scholar: lookup
  28. Tingay DG, Farrell O, Thomson J, Perkins EJ, Pereira-Fantini PM, Waldmann AD, Rüegger C, Adler A, Davis PG, Frerichs I. Imaging the Respiratory Transition at Birth: Unraveling the Complexities of the First Breaths of Life.. Am J Respir Crit Care Med 2021 Jul 1;204(1):82-91.
    doi: 10.1164/rccm.202007-2997OCpubmed: 33545023google scholar: lookup
  29. Whited L, Hashmi MF, Graham DD. Abnormal Respirations.. 2023 Jan;.
    pubmed: 29262235
  30. Luna SP, Taylor PM, Wheeler MJ. Cardiorespiratory, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anaesthesia.. J Vet Pharmacol Ther 1996 Aug;19(4):251-8.
    doi: 10.1111/j.1365-2885.1996.tb00046.xpubmed: 8866452google scholar: lookup
  31. West JB, Luks A. Mechanics of breathing: how the lung is supported and moved. Resp Physiol (2016) 108–41.
  32. West JB, Luks A. Difussion: how gas gets across the blood-gas barrier. In: West JB, Luks A, editors. West's Respiratory Physiology: The Essentials. 10th ed. Philadelphia: Wolters Kluwer, Alphen aan den Rijn. (2016). p28–40.
  33. Mosing M, Waldmann AD, Sacks M, Buss P, Boesch JM, Zeiler GE, Hosgood G, Gleed RD, Miller M, Meyer LCR, Böhm SH. What hinders pulmonary gas exchange and changes distribution of ventilation in immobilized white rhinoceroses (Ceratotherium simum) in lateral recumbency?. J Appl Physiol (1985) 2020 Nov 1;129(5):1140-1149.
    doi: 10.1152/japplphysiol.00359.2020pubmed: 33054661google scholar: lookup
  34. West JB, Luks A. Ventilation-perfusion relationships: how matching of gas and blood determines gas exchange. Resp Physiol (2016) 63–86.
  35. Hopkins SR, Henderson AC, Levin DL, Yamada K, Arai T, Buxton RB, Prisk GK. Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect.. J Appl Physiol (1985) 2007 Jul;103(1):240-8.
    doi: 10.1152/japplphysiol.01289.2006pmc: PMC2399899pubmed: 17395757google scholar: lookup
  36. Sacks M, Byrne DP, Herteman N, Secombe C, Adler A, Hosgood G, Raisis AL, Mosing M. Electrical impedance tomography to measure lung ventilation distribution in healthy horses and horses with left-sided cardiac volume overload.. J Vet Intern Med 2021 Sep;35(5):2511-2523.
    doi: 10.1111/jvim.16227pmc: PMC8478054pubmed: 34347908google scholar: lookup
  37. Mosing M, Böhm SH, Rasis A, Hoosgood G, Auer U, Tusman G, Bettschart-Wolfensberger R, Schramel JP. Physiologic Factors Influencing the Arterial-To-End-Tidal CO(2) Difference and the Alveolar Dead Space Fraction in Spontaneously Breathing Anesthetised Horses.. Front Vet Sci 2018;5:58.
    doi: 10.3389/fvets.2018.00058pmc: PMC5882784pubmed: 29644221google scholar: lookup
  38. Lumb AB, Slinger P. Hypoxic pulmonary vasoconstriction: physiology and anesthetic implications.. Anesthesiology 2015 Apr;122(4):932-46.
    doi: 10.1097/ALN.0000000000000569pubmed: 25587641google scholar: lookup
  39. Lafortuna CL, Saibene F, Albertini M, Clement MG. The regulation of respiratory resistance in exercising horses.. Eur J Appl Physiol 2003 Oct;90(3-4):396-404.
    doi: 10.1007/s00421-003-0925-0pubmed: 12920523google scholar: lookup
  40. Staffieri F, Driessen B. Field Anesthesia in the Equine. Clin Techn Equine Pract (2007) 6:111–9.
    doi: 10.1053/j.ctep.2007.05.003google scholar: lookup

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