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The Journal of veterinary medical science2021; 83(4); 643-647; doi: 10.1292/jvms.20-0397

Comparison of intraoperative cardiorespiratory and behavioral responses to medetomidine combined with tramadol or butorphanol during standing laparoscopic ovariectomy in horses.

Abstract: The purpose of this study was to assess the cardiorespiratory and behavioral responses to the combination of medetomidine and tramadol (M-T) or butorphanol (M-B) in standing laparoscopic ovariectomy in horses. One ovary was removed under M-T and the contralateral ovary was removed under M-B with at least 4 weeks between operations at random. Horses were sedated using intravenous medetomidine (5 µg/kg) followed by tramadol (1 mg/kg) or butorphanol (10 µg/kg) after 5 min. Sedation was maintained through the repeated injection of medetomidine (1 µg/kg) and tramadol (0.4 mg/kg) or medetomidine (1 µg/kg) and butorphanol (4 µg/kg) every 15 min. Cardiorespiratory function and behavioral responses, including, sedation, ataxia, and analgesia, were assessed during the surgery. There were no significant differences in cardiorespiratory values and sedation and analgesia scores between M-T and M-B. Ataxia scores were significantly lower in M-T than in M-B. This result suggests that M-T could maintain smooth and stable standing surgery with minimal cardiorespiratory changes in horses.
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Publication Date: 2021-02-11 PubMed ID: 33583912PubMed Central: PMC8111346DOI: 10.1292/jvms.20-0397Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study compared the effects of two combinations of drugs on the cardiorespiratory and behavioral responses of horses during surgical removal of ovaries. The experiment involved the use of medetomidine and tramadol or medetomidine and butorphanol, with no significant differences found in either cardiorespiratory values or sedation and relief of pain.

Objective and Methodology

  • The primary aim of this research was to investigate how the combination of two different sets of drugs: medetomidine and tramadol (M-T) and medetomidine and butorphanol (M-B) affect horses’ cardiorespiratory function and behaviours during a laparoscopic ovariectomy.
  • The procedure involved removing one ovary under the influence of M-T and the other under M-B, spacing these procedures at least four weeks apart. The order in which these drugs were administered was randomized for each operation.
  • The sedative medetomidine (at 5 µg/kg) was administered intravenously, followed either by tramadol (at 1 mg/kg) or butorphanol (at 10 µg/kg) 5 minutes later. These drugs were reapplied regularly throughout the procedure: medetomidine (1 µg/kg) with tramadol (0.4 mg/kg) or medetomidine (1 µg/kg) with butorphanol (4 µg/kg) every 15 minutes.

Assessment and Results

  • The team examined cardiorespiratory function and behavioural responses during the operation. Parameters for evaluating these include the level of sedation, ataxia (lack of voluntary coordination of muscle movements), and analgesia (inability to feel pain).
  • The study found no noticeable differences in cardiorespiratory parameters or the scores for sedation and analgesia between M-T and M-B. However, when it came to ataxia, there was a significant decrease in scores for the horses treated with M-T compared to those treated with M-B.

Conclusion

  • Based on the experiment results, the researchers suggest that combining medetomidine and tramadol could enable smoother and more stable surgeries for horses, with minimal changes in cardiorespiratory functions.
  • This observation leads to the possibility that the M-T combination might be a preferable choice for such procedures, as it resulted in noticeably less ataxia than the M-B combination.

Cite This Article

APA
Kim A, Sasaki N, Lee I, Seo JP. (2021). Comparison of intraoperative cardiorespiratory and behavioral responses to medetomidine combined with tramadol or butorphanol during standing laparoscopic ovariectomy in horses. J Vet Med Sci, 83(4), 643-647. https://doi.org/10.1292/jvms.20-0397

Publication

The Journal of veterinary medical science
ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 83
Issue: 4
Pages: 643-647

Researcher Affiliations

Kim, Ahram
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
Sasaki, Naoki
  • Department of Clinical Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.
Lee, Inhyung
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
Seo, Jong-Pil
  • Department of Veterinary Clinical Sciences, Jeju National University, Jeju 63243, Republic of Korea.

MeSH Terms

  • Analgesics, Opioid / pharmacology
  • Animals
  • Butorphanol / pharmacology
  • Female
  • Heart Rate
  • Horses
  • Hypnotics and Sedatives / pharmacology
  • Laparoscopy / veterinary
  • Medetomidine / pharmacology
  • Ovariectomy / veterinary
  • Tramadol

Conflict of Interest Statement

The authors declare no financial or personal conflicts of interest.

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Citations

This article has been cited 1 times.
  1. Straticò P, Guerri G, Palozzo A, Varasano V, Petrizzi L. Current Use of Equine Laparoscopy in Urogenital Disorders: A Scoping Review of the Literature from 2000 to 2021. Vet Sci 2022 Jan 22;9(2).
    doi: 10.3390/vetsci9020041pubmed: 35202295google scholar: lookup
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