Comparison of paste and suspension formulations of omeprazole in the healing of gastric ulcers in racehorses in active training.
Abstract: To compare effects of a commercially available omeprazole paste and a compounded omeprazole suspension on healing of gastric ulcers in Thoroughbred racehorses in active training. Methods: Randomized controlled trial. Methods: 32 horses with gastric ulcers. Methods: Horses were assigned to 2 groups on the basis of endoscopic gastric ulcer severity. Group-1 horses were treated with omeprazole suspension for 30 days and with omeprazole paste for an additional 30 days. Group-2 horses were treated with omeprazole paste for 30 days and omeprazole suspension for an additional 30 days. Serum omeprazole concentrations were measured in 4 additional healthy horses after administration of a single dose of each formulation. In all instances, omeprazole was administered at a dose of 4 mg/kg (1.8 mg/lb), p.o.. Results: Ulcer severity scores on day 0 were not significantly different between groups. On day 30, ulcer severity score was significantly decreased, compared with day-0 score, in group-2 but not in group-1 horses. On day 60, ulcer severity score was significantly decreased, compared with day-0 and day-30 scores, in group-1 horses. In group-2 horses, ulcer severity score on day 60 was significantly lower than the day-0 score but was not significantly different from the day-30 score. Maximum observed serum omeprazole concentration and area under the concentration-time curve were significantly higher after administration of the paste versus the suspension formulation. Conclusions: Results suggest that although administration of the commercially available paste omeprazole formulation was effective in promoting healing of gastric ulcers in these horses, administration of the compounded omeprazole suspension was ineffective.
Publication Date: 2002-10-22 PubMed ID: 12387383DOI: 10.2460/javma.2002.221.1139Google Scholar: Lookup
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- Clinical Trial
- Journal Article
- Randomized Controlled Trial
Summary
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The research article evaluates the effectiveness of commercial paste-form and suspension-form omeprazole in treating gastric ulcers in racehorses. The study suggests that while the paste formulation proves beneficial, the suspension form lacks effectiveness.
Study Overview
- The research was designed as a randomized control trial involving 32 thoroughbred racehorses diagnosed with gastric ulcers. These horses were randomly assigned to two groups based on the endoscopic severity of gastric ulcers.
- Group-1 horses were treated with an omeprazole suspension for 30 days, followed by an omeprazole paste for the next 30 days. On the other hand, Group-2 horses were first treated with an omeprazole paste for 30 days and then on omeprazole suspension for the subsequent 30 days. The dose of omeprazole was kept consistent for both formulations at 4 mg/kg.
Results Analysis
- The scoring of ulcer severity on the first day revealed no significant difference between the two groups.
- On the 30th day, the ulcer severity score significantly decreased in Group-2 (first treated with the paste form) compared to initial scores, but this decrease was not observed in Group-1 (first treated with suspension).
- By the 60th day, ulcer severity significantly decreased in Group-1 horses (treated with paste secondly) in comparison with the initial scores and scores on the 30th day. For Group-2, ulcer severity scores on day 60 were significantly lower than initial scores but were not notably different from the 30-day scores.
- Serum omeprazole concentrations were measured in four additional healthy horses after administering a single dose of each formulation. The results indicated significantly higher maximum observed serum omeprazole concentration and area under the concentration-time curve after administering the paste form compared to the suspension.
Conclusions Drawn
- The results suggest that the administration of the commercially available paste omeprazole formulation effectively promoted the healing of gastric ulcers in racehorses. In contrast, the administration of the compounded omeprazole suspension appeared to be ineffective in healing gastric ulcers in the horses.
Cite This Article
APA
Nieto JE, Spier S, Pipers FS, Stanley S, Aleman MR, Smith DC, Snyder JR.
(2002).
Comparison of paste and suspension formulations of omeprazole in the healing of gastric ulcers in racehorses in active training.
J Am Vet Med Assoc, 221(8), 1139-1143.
https://doi.org/10.2460/javma.2002.221.1139 Publication
Researcher Affiliations
- Department of Surgical and Radiological Sciences, University of California, Davis 95616, USA.
MeSH Terms
- Animals
- Anti-Ulcer Agents / administration & dosage
- Anti-Ulcer Agents / pharmacokinetics
- Anti-Ulcer Agents / therapeutic use
- Cross-Over Studies
- Horse Diseases / drug therapy
- Horses
- Ointments
- Omeprazole / administration & dosage
- Omeprazole / pharmacokinetics
- Omeprazole / therapeutic use
- Physical Conditioning, Animal
- Severity of Illness Index
- Single-Blind Method
- Stomach Ulcer / drug therapy
- Stomach Ulcer / veterinary
- Suspensions
- Time Factors
- Treatment Outcome
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