Comparison of radiofrequency treatment and mechanical debridement of fibrillated cartilage in an equine model.
Abstract: To compare a radiofrequency energy (RFE) prototype probe to mechanical debridement (MD) and a commercially available RFE system used for chondroplasty in the treatment of an experimentally created partial thickness cartilage lesion in horses. The study design was experimental, randomized complete block, n=8, using fifteen mature ponies. Methods: Grade 2 to 3 cartilage lesions were prepared in both patellae. After 10 months duration, the injuries were used to study the effects of MD, a commercially available bipolar RFE device (CoVac 50; ArthroCare Corporation) and a prototype monopolar RFE device (Smith & Nephew Endoscopy). Six months after treatment the patellae were examined for chondrocyte viability and cartilage structure. Results: Mean depth of cell death was significantly different among groups (controls, MD <prototype<CoVac 50) (P<0.05). Total histologic scores did not demonstrate any significant differences among the controls, MD and prototype RFE groups, which were all better than the CoVac 50 scores (P<0.05). There was a trend for the prototype RFE probe treated regions to have better surface structural characteristics than MD (P=0.11). Cartilage thickness was greater for the prototype RFE group than all other groups, and was the thinnest for the CoVac 50 group (P<0.05). Conclusions: When thermal chondroplasty is performed with a power-controlled prototype RFE probe, there is a better surface smoothing effect compared to MD, which causes less chondrocyte death and has the potential to maintain thicker cartilage compared to the commercially available RFE system.
Publication Date: 2008-02-22 PubMed ID: 18288343DOI: 10.3415/VCOT-07-01-0004Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article presents a comparative study on radiofrequency energy (RFE) prototype probe and mechanical debridement (MD) used in the treatment of partial thickness cartilage lesions in horses.
Objectives and Methodology
- The main aim of this research was to compare the effect of a radiofrequency energy (RFE) prototype probe with mechanical debridement (MD) and a commercially available RFE system (CoVac 50) used for treating experimentally created partial thickness cartilage lesions in horses.
- The experimental design used was randomized complete block, involving fifteen mature ponies.
- In the research, Grade 2 to 3 cartilage lesions were created in both the patellae (kneecaps) of the ponies. After ten months, these injuries were treated using MD, CoVac 50, or a prototype monopolar RFE device by Smith & Nephew Endoscopy.
- The patellae were then examined after six months of each treatment for chondrocyte (cartilage cells) viability and cartilage structure.
Results
- The study found significant difference in the mean depth of cell death among the various groups, with the sequence of cell death being control, MD, prototype RFE probe, and CoVac 50.
- No significant differences were noted in the total histologic scores among the controls, MD, and prototype groups, which all had better scores than the CoVac 50 group.
- The regions treated with the prototype RFE probe exhibited better surface structural characteristics than the MD.
- Regarding cartilage thickness, the prototype RFE group had the greatest thickness among all groups, with the thinnest cartilage being in the CoVac 50 group.
Conclusions
- The research concluded that treatment with a power-controlled prototype RFE probe yielded a better surface smoothing effect as compared to MD, causing less chondrocyte death.
- The prototype RFE system demonstrated the potential to maintain thicker cartilage compared to the commercially available RFE system (CoVac 50).
Cite This Article
APA
Edwards RB, Lu Y, Cole BJ, Muir P, Markel MD.
(2008).
Comparison of radiofrequency treatment and mechanical debridement of fibrillated cartilage in an equine model.
Vet Comp Orthop Traumatol, 21(1), 41-48.
https://doi.org/10.3415/VCOT-07-01-0004 Publication
Researcher Affiliations
- Fairfield Equine Associates, Newtown, Connecticut, USA.
MeSH Terms
- Animals
- Arthroscopy / methods
- Arthroscopy / veterinary
- Cartilage Diseases / radiotherapy
- Cartilage Diseases / surgery
- Cartilage Diseases / veterinary
- Cartilage, Articular / pathology
- Cartilage, Articular / radiation effects
- Chondromalacia Patellae / radiotherapy
- Chondromalacia Patellae / surgery
- Chondromalacia Patellae / veterinary
- Debridement / instrumentation
- Debridement / methods
- Debridement / veterinary
- Disease Models, Animal
- Horse Diseases / radiotherapy
- Horse Diseases / surgery
- Horses
- Radio Waves
- Random Allocation
- Treatment Outcome
Citations
This article has been cited 10 times.- Ząbek T, Witarski W, Szmatoła T, Sawicki S, Mrozowicz J, Samiec M. Trichostatin A-Mediated Epigenetic Modulation Predominantly Triggers Transcriptomic Alterations in the Ex Vivo Expanded Equine Chondrocytes.. Int J Mol Sci 2022 Oct 29;23(21).
- Huber M, Schlosser D, Stenzel S, Maier J, Pattappa G, Kujat R, Striegl B, Docheva D. Quantitative Analysis of Surface Contouring with Pulsed Bipolar Radiofrequency on Thin Chondromalacic Cartilage.. Biomed Res Int 2020;2020:1242086.
- Anderson SR, Faucett SC, Flanigan DC, Gmabardella RA, Amin NH. The history of radiofrequency energy and Coblation in arthroscopy: a current concepts review of its application in chondroplasty of the knee.. J Exp Orthop 2019 Jan 14;6(1):1.
- Mardones R, Larrain C. Cartilage restoration technique of the hip.. J Hip Preserv Surg 2016 Apr;3(1):30-6.
- Spahn G, Hofmann GO, von Engelhardt LV. Mechanical debridement versus radiofrequency in knee chondroplasty with concomitant medial meniscectomy: 10-year results from a randomized controlled study.. Knee Surg Sports Traumatol Arthrosc 2016 May;24(5):1560-8.
- Ganguly K, McRury ID, Goodwin PM, Morgan RE, Augé WK 2nd. Targeted In Situ Biosynthetic Transcriptional Activation in Native Surface-Level Human Articular Chondrocytes during Lesion Stabilization.. Cartilage 2012 Apr;3(2):141-55.
- Ganguly K, McRury ID, Goodwin PM, Morgan RE, Augé WK 2nd. Native Chondrocyte Viability during Cartilage Lesion Progression: Normal to Surface Fibrillation.. Cartilage 2010 Oct;1(4):306-11.
- Huber M, Eder C, Loibl M, Berner A, Zellner J, Kujat R, Nerlich M, Gehmert S. RFE based chondroplasty in wrist arthroscopy indicates high risk for chrondocytes especially for the bipolar application.. BMC Musculoskelet Disord 2015 Jan 31;16(1):6.
- Ganguly K, McRury ID, Goodwin PM, Morgan RE, Augé Ii WK. Histopomorphic evaluation of radiofrequency mediated débridement chondroplasty.. Open Orthop J 2010 Jun 29;4:211-20.
- Menendez M, Ishihara A, Weisbrode S, Bertone A. Radiofrequency energy on cortical bone and soft tissue: a pilot study.. Clin Orthop Relat Res 2010 Apr;468(4):1157-64.
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