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Veterinary surgery : VS2021; 50(5); 990-998; doi: 10.1111/vsu.13627

Comparison of sedation quality and safety of detomidine and romifidine as a continuous rate infusion for standing elective laparoscopic ovariectomy in mares.

Abstract: To compare efficacy and safety of a continuous rate infusion of detomidine hydrochloride and romifidine hydrochloride for standing elective bilateral laparoscopic ovariectomy in mares. Methods: Blinded, randomized prospective clinical study. Methods: Eighteen healthy mares presenting for elective bilateral ovariectomy METHODS: Mares were randomly assigned to one of two sedation protocols. Prior to surgery, baseline head height, heart rate, respiratory rate, and postural sway were recorded. An IV loading dose of α2-agonist (46 μg/kg romifidine or 13.9 μg/kg detomidine) was administered. Standing sedation was maintained with a continuous rate infusion of the respective α2-agonist (126 μg/kg/h romifidine or 37.8 μg/kg/h detomidine). Intraoperative measurements included respiratory rate, heart rate, head height, postural sway, and response to surgical stimulus. Postoperatively, fecal output was recorded, and pain scoring was performed using composite pain score and visual analog scales. Results: Three of 18 horses required additional α-2 agonists: one detomidine and two romifidine and butorphanol. Head height during surgery was lower (p < .001) in mares receiving detomidine. Postural sway around the vertical axis was greater in mares sedated with detomidine rather than romifidine (p = .013). No differences were detected in intraoperative heart rate, postoperative pain scores or postoperative fecal output between sedation techniques. Conclusions: Comparable scores for surgical stimulation and sedation were measured in both sedation groups. No differences in postoperative analgesia or manure production were identified. Conclusions: Romifidine appears suitable as an alternative to detomidine and may limit ataxia and head drop in sedated horses.
© 2021 American College of Veterinary Surgeons.
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Publication Date: 2021-04-01 PubMed ID: 33797093DOI: 10.1111/vsu.13627Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Veterinary

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the efficacy and safety of using detomidine hydrochloride and romifidine hydrochloride as continuous rate infusions for standing elective bilateral laparoscopic ovariectomy in mares. The study concludes that both sedation methods perform comparably, with no notable differences in postoperative analgesia or fecal output. However, mares sedated with romifidine had less postural sway and head drop, suggesting it may be a suitable alternative to detomidine.

Objective and Methodology

  • The aim of this research was to compare the outcomes of using detomidine hydrochloride and romifidine hydrochloride as continuous rate infusions for standing elective bilateral laparoscopic ovariectomy in mares.
  • The study was designed as a blinded, randomized prospective clinical trial. Eighteen healthy mares were selected, all of which were scheduled for a laparoscopic ovariectomy.
  • Each mare was randomly assigned to one of two sedation protocols: either detomidine hydrochloride or romifidine hydrochloride.
  • Various parameters including head height, heart rate, respiratory rate, and postural sway were measured before surgery, and during the procedure while maintaining the sedation at a continuous rate.
  • The study also included monitoring the mares’ reactions to surgical stimuli, including respiratory and heart rates, head height, postural sway, as well as fecal output and pain scores postoperatively.

Results of the Study

  • It was observed that three out of eighteen horses required additional doses of α-2 agonists: one from the detomidine group and two from the romifidine group.
  • Mares receiving detomidine had lower head height during surgery when compared to those receiving romifidine. It was also found that postural sway around the vertical axis was greater in mares receiving detomidine.
  • Both sedation techniques were comparable in terms of intraoperative heart rate, postoperative pain scores, and postoperative fecal output.
  • Responses to surgical stimuli were similar in both groups of mares sedated with either detomidine or romifidine.

Conclusions Derived from the Study

  • There were no significant differences in postoperative analgesia or manure production between the mares in both sedation groups.
  • Given the distracting challenge of ataxia or severe head drop during the surgery, the study proposes that romifidine could be a preferred alternative to detomidine due to its tendency to limit these issues in sedated horses.
  • Despite the minor differences observed during sedation, both drugs showed similar efficacy and safety for the purpose of the study.

Cite This Article

APA
Lawless SP, Moorman VJ, Hendrickson DA, Mama KR. (2021). Comparison of sedation quality and safety of detomidine and romifidine as a continuous rate infusion for standing elective laparoscopic ovariectomy in mares. Vet Surg, 50(5), 990-998. https://doi.org/10.1111/vsu.13627

Publication

Veterinary surgery : VS
ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 50
Issue: 5
Pages: 990-998

Researcher Affiliations

Lawless, Shauna P
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Moorman, Valerie J
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Hendrickson, Dean A
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Mama, Khursheed R
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.

MeSH Terms

  • Adrenergic alpha-2 Receptor Agonists / administration & dosage
  • Adrenergic alpha-2 Receptor Agonists / pharmacology
  • Anesthesia / veterinary
  • Animals
  • Butorphanol / administration & dosage
  • Butorphanol / pharmacology
  • Female
  • Heart Rate / drug effects
  • Horses / surgery
  • Hypnotics and Sedatives / administration & dosage
  • Hypnotics and Sedatives / pharmacology
  • Imidazoles / administration & dosage
  • Imidazoles / pharmacology
  • Infusions, Intravenous / veterinary
  • Laparoscopy / veterinary
  • Ovariectomy / methods
  • Ovariectomy / veterinary
  • Pain / veterinary
  • Prospective Studies

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