Comparison of standard and radionuclide methods for measurement of glomerular filtration rate and effective renal blood flow in female horses.
Abstract: Comparison of standard and radionuclide methods for measuring glomerular filtration rate (GFR) and effective renal blood flow (ERBF) was performed in 8 healthy female horses. Inulin and p-aminohippurate solutions were administered IV as a bolus, followed by sustained administration. Urine and plasma inulin and p-aminohippurate concentrations and urine volume were measured. Glomerular filtration rate and ERBF were calculated on the basis of these measurements. Glomerular filtration rate and ERBF were measured on the basis of plasma clearance of the radiopharmaceuticals, 99mTc-labeled diethylene-triaminepentaacetic acid (99mTc-DTPA) and [131I]-o-iodohippuric acid (131I-OIH), respectively. Mean +/- SEM GFR, using inulin, was 1.83 +/- 0.21 ml/min/kg of body weight. Mean GFR, using 99mTc-DTPA was 1.79 +/- 0.18 ml/min/kg. Mean ERBF, using p-aminohippurate, was 15.13 +/- 1.28 ml/min/kg. Mean ERBF, using 131I-OIH, was 18.42 +/- 1.57 ml/min/kg. Analysis of variance indicated no significant difference between mean values for GFR and ERBF. Radionuclide measurement of GFR and ERBF compared well with standard methods and is an alternative technique to the cumbersome standard methods for determination of GFR and ERBF in horses.
Publication Date: 1992-09-01 PubMed ID: 1416364
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research discusses the comparison of standard and radionuclide methods for measuring kidney function, specifically the glomerular filtration rate (GFR) and effective renal blood flow (ERBF), in healthy female horses. The findings demonstrate that radionuclide methods are a viable alternative to traditional methods for this assessment.
Methods Used in The Research
- The researchers used 8 healthy female horses for this study.
- The experiment involved the administration of inulin and p-aminohippurate solutions intravenously as a bolus, followed by sustained administration. Both these substances are often used in renal function tests.
- To measure the glomerular filtration rate (GFR) and effective renal blood flow (ERBF), the researchers measured urine and plasma inulin and p-aminohippurate concentrations and urine volume.
- The study also included a measurement of GFR and ERBF based on plasma clearance of the radiopharmaceuticals, 99mTc-labeled diethylene-triaminepentaacetic acid (99mTc-DTPA) and [131I]-o-iodohippuric acid (131I-OIH), respectively.
Main Findings from the Research
- The standard method using inulin showed a mean GFR of 1.83 +/- 0.21 ml/min/kg of body weight in the horses.
- Using the radionuclide method with 99mTc-DTPA, the mean GFR rate was slightly lower, coming in at 1.79 +/- 0.18 ml/min/kg.
- For the effective renal blood flow (ERBF), standard method using p-aminohippurate showed a mean ERBF of 15.13 +/- 1.28 ml/min/kg.
- The radionuclide method with 131I-OIH showed a higher mean ERBF of 18.42 +/- 1.57 ml/min/kg.
Conclusions Drawn from the Research
- No significant differences were found between the mean values for GFR and ERBF when comparing the standard and radionuclide methods.
- Based on the results, the researchers concluded that radionuclide measurement of GFR and ERBF can be a practical alternative to the traditional (standard) methods that are often cumbersome.
This suggests that the radionuclide method could be used more extensively for determining GFR and ERBF in horses in the future.
Cite This Article
APA
Matthews HK, Andrews FM, Daniel GB, Jacobs WR, Held JP.
(1992).
Comparison of standard and radionuclide methods for measurement of glomerular filtration rate and effective renal blood flow in female horses.
Am J Vet Res, 53(9), 1612-1616.
Publication
Researcher Affiliations
- Department of Rural Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901.
MeSH Terms
- Animals
- Female
- Glomerular Filtration Rate / veterinary
- Horses / physiology
- Inulin
- Iodine Radioisotopes
- Iodohippuric Acid
- Kidney / diagnostic imaging
- Kidney / physiology
- Organotechnetium Compounds
- Pentetic Acid
- Radionuclide Imaging
- Renal Circulation
- p-Aminohippuric Acid
Citations
This article has been cited 1 times.- Satoh H, Abe S, Kato M, Saito J, Furuhama K. Optimum conditions for serum clearance of iodixanol, applicable to the estimation of glomerular filtration rate in horses. Vet Res Commun 2011 Oct;35(7):463-8.
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