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The Canadian veterinary journal = La revue veterinaire canadienne2019; 60(6); 637-643;

Comparison of the glucose and insulin responses of horses to 2 formulations of corn syrup.

Abstract: The objectives of this study were to compare the insulin and glucose responses of horses to 2 formulations of corn syrup, [Karo Light (Karo) available in the United States, and Crown Lily White (Crown), available in Canada]. Horses were evaluated under both fed ( = 14) and fasted ( = 10) conditions. Using a randomized crossover design, each horse underwent an oral sugar test using Karo or Crown syrup. There were no significant differences in insulin or glucose time of maximum concentration (T), maximum concentration (C), or area under the curve (AUC) or in insulin or glucose concentrations at individual timepoints during fed or fasted conditions. Bland-Altman analysis of insulin at 75 minutes indicated a mean bias of 28.7 pmol/L, with 95% limits of agreement from -83.9 to 140.6 pmol/L (fed) and a mean bias of 11.5 pmol/L, with 95% limits of agreement from -78.9 to 101.9 pmol/L (fasted). These findings suggest that Karo and Crown syrup produce similar glucose and insulin responses in horses. Les objectifs de cette étude consistaient à comparer les réponses à l’insuline et au glucose de chevaux pour deux formulations de sirop de maïs, [Karo Light (Karo), disponible aux États-Unis, et Crown Lily White (Crown), disponible au Canada]. Les chevaux ont été évalués dans des conditions non à jeun ( = 14) et à jeun ( = 10). Chaque cheval a subi un test au glucose oral avec du sirop Karo ou Crown en utilisant une conception croisée sur échantillon aléatoire. Il n’y avait pas de différence significative quant au temps de la concentration maximale de l’insuline ou du glucose (T), de la concentration maximale (C) ou de la surface sous la courbe (AUC) ou des concentrations d’insuline ou de glucose à des moments individuels durant les conditions non à jeun ou à jeun. Une analyse Bland-Altman de l’insuline à 75 minutes a indiqué un écart moyen de 28,7 pmol/L, avec 95 % de limites de concordance de −83,9 à 140,6 pmol/L (nourris) et un écart moyen de 11,5 pmol/L, avec 95 % de limites de concordance de −78,9 à 101,9 pmol/L (à jeun). Ces résultats suggèrent que les sirops Karo et Crown produisent des réponses semblables au glucose et à l’insuline chez les chevaux.(Traduit par Isabelle Vallières).
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Publication Date: 2019-06-04 PubMed ID: 31156265PubMed Central: PMC6515809
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study investigates how two different corn syrup brands, Karo and Crown, influence the blood sugar and insulin levels in horses. The research found no significant difference in either the glucose or insulin responses to either brand.

Research Design and Methodology

  • The research was conducted on horses under two different conditions: fed and fasted. In total, 14 horses were in fed conditions and 10 horses were in fasted conditions.
  • This study employed a randomized crossover design which means that each horse was tested with both Karo and Crown syrups. This methodological approach ensures that results account for individual variation among horses, thereby increasing the overall reliability of the findings.

Parameters Measured

  • The study mainly analyzed the insulin and glucose responses of horses to the corn syrups, focusing on several specific parameters including:
    • Time of maximum concentration (T)
    • Maximum concentration (C)
    • The area under the curve (AUC)
  • The insulin and glucose concentrations were measured at individual timepoints during fed or fasted conditions, allowing the researchers to assess how the corn syrups’ effects might vary with feeding state.

Results and Interpretation

  • No significant differences were observed in the insulin or glucose responses of horses to Karo and Crown syrups. This includes comparable times of maximum concentration, maximum concentrations, and areas under the curve.
  • The study also reports a Bland-Altman analysis, which assesses agreement between two quantitative measurements. This statistical method applied to an insulin measurement taken 75 minutes post-feeding revealed the mean deviations (bias) were 28.7 pmol/L for fed horses and 11.5 pmol/L for fasted horses.
  • The 95% limits of agreement, which represent the range where differences between the two methods of measurement are expected to lie for 95% of future sample pairs, spanned from -83.9 to 140.6 pmol/L for the fed horses and from -78.9 to 101.9 pmol/L for those fasted. These ranges convey that there can be a considerable variation in insulin response among individual horses, but it’s not related to which syrup they are fed.

Conclusion

  • Based on these findings, the researchers concluded that both Karo and Crown corn syrups elicited similar glucose and insulin responses in horses, regardless of whether they had been previously fed or fasted. Thus, these two brands of corn syrups appear to have equivalent effects on horses’ glycemic and insulin responses.

Cite This Article

APA
Moser K, Banse H. (2019). Comparison of the glucose and insulin responses of horses to 2 formulations of corn syrup. Can Vet J, 60(6), 637-643.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 60
Issue: 6
Pages: 637-643

Researcher Affiliations

Moser, Kira
  • Faculty of Veterinary Medicine, University of Calgary, Calgary Alberta T2N 4Z1 (Moser); Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, Louisiana, USA 70803 (Banse).
Banse, Heidi
  • Faculty of Veterinary Medicine, University of Calgary, Calgary Alberta T2N 4Z1 (Moser); Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, Louisiana, USA 70803 (Banse).

MeSH Terms

  • Animals
  • Area Under Curve
  • Blood Glucose
  • Canada
  • Cross-Over Studies
  • Glucose
  • Horses
  • Insulin
  • Zea mays

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Citations

This article has been cited 1 times.
  1. Warnken T, Schaub C, Delarocque J, Frers F, Feige K, Sonntag J, Reiche DB. Palatability, glycemic, and insulinemic responses to various carbohydrate formulations: Alternatives for the diagnosis of insulin dysregulation in horses?. J Vet Intern Med 2023 Jan;37(1):282-291.
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