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Standards in genomic sciences2015; 10; 32; doi: 10.1186/s40793-015-0009-x

Complete genome sequence of Actinobacillus equuli subspecies equuli ATCC 19392(T).

Abstract: Actinobacillus equuli subsp. equuli is a member of the family Pasteurellaceae that is a common resident of the oral cavity and alimentary tract of healthy horses. At the same time, it can also cause a fatal septicemia in foals, commonly known as sleepy foal disease or joint ill disease. In addition, A. equuli subsp. equuli has recently been reported to act as a primary pathogen in breeding sows and piglets. To better understand how A. equuli subsp. equuli can cause disease, the genome of the type strain of A. equuli subsp. equuli, ATCC 19392(T), was sequenced using the PacBio RSII sequencing system. Its genome is comprised of 2,431,533 bp and is predicted to encode 2,264 proteins and 82 RNAs.
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Publication Date: 2015-06-07 PubMed ID: 26203343PubMed Central: PMC4511653DOI: 10.1186/s40793-015-0009-xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper presents the genome sequencing of Actinobacillus equuli subspecies equuli ATCC 19392(T), a bacterium that is typically found in horses but can cause disease in foals and pigs, to help understand its disease-causing mechanisms.

Genomic Information of Actinobacillus equuli subsp. equuli

The genus Actinobacillus, family Pasteurellaceae, includes species such as the A. equuli subsp. equuli that dwell in the oral cavity and alimentary tract of healthy horses. However, the same bacteria can lead to lethal septicemia in foals, typically recognised as sleepy foal disease or joint illness. With the PacBio RSII sequencing platform, the complete DNA sequence or genome of the type strain of this bacteria, ATCC 19392(T), was obtained.

  • The PacBio RSII sequencing system is a sequencer that employs single molecule, real-time (SMRT) technology to deliver highly accurate long reads. SMRT technology can provide crucial insights into the genomic organization of organisms, enabling targeted research into disease-causing mechanisms.
  • The genome of this bacterium is made up of 2,431,533 base pairs (bp). The base pairs are the building blocks of DNA and the number of base pairs gives an indication of the size of the genome.

Protein and RNA Encoding

The genome of A. equuli subsp. equuli ATCC 19392(T) is anticipated to code for a large number of proteins and RNAs.

  • Specifically, it is predicted to encode 2,264 proteins. Proteins are vital for the bacterium’s existence and can offer valuable insights into its metabolism and its pathogenic capabilities. By understanding the proteins that this bacterium encodes for, researchers can get a sense of its potential functions and disease-causing mechanisms.
  • It is also expected to encode 82 RNAs which could include messenger RNA, transfer RNA and ribosomal RNA all of which play critical roles in protein synthesis and regulation of gene expression. Analysis of the predicted RNA can help understand the regulatory mechanisms of the bacterium.

Implications

This research is not just about sequencing the genome of A. equuli subsp. equuli. Understanding the genome gives invaluable information about the biology of the bacterium, its capabilities and its pathogenicity. In addition, it may provide potential drug targets for combating diseases caused by this bacterium. Besides, advanced knowledge about the bacterium might potentially contribute to the development of countermeasures for sleepy foal disease, joint ill disease and diseases in breeding sows and piglets which are reportedly linked with A. equuli subsp. equuli’s pathogenicity.

Cite This Article

APA
Huang BF, Kropinski AM, Bujold AR, MacInnes JI. (2015). Complete genome sequence of Actinobacillus equuli subspecies equuli ATCC 19392(T). Stand Genomic Sci, 10, 32. https://doi.org/10.1186/s40793-015-0009-x

Publication

Standards in genomic sciences
ISSN: 1944-3277
NlmUniqueID: 101530505
Country: England
Language: English
Volume: 10
Pages: 32

Researcher Affiliations

Huang, Barbara F
  • Department of Pathobiology, University of Guelph, Ontario Veterinary College, Ontario N1G 2 W1, Canada.
Kropinski, Andrew M
  • Department of Pathobiology, University of Guelph, Ontario Veterinary College, Ontario N1G 2 W1, Canada.
Bujold, Adina R
  • Department of Pathobiology, University of Guelph, Ontario Veterinary College, Ontario N1G 2 W1, Canada.
MacInnes, Janet I
  • Department of Pathobiology, University of Guelph, Ontario Veterinary College, Ontario N1G 2 W1, Canada.

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Citations

This article has been cited 3 times.
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