Complete genome sequence of equid herpesvirus 3.
Abstract: Equid herpesvirus 3 (EHV-3) is a member of the subfamily Alphaherpesvirinae that causes equine coital exanthema. Here, we report the first complete genome sequence of EHV-3. The 151,601-nt genome encodes 76 distinct genes like other equine alphaherpesviruses, but genetically, EHV-3 is significantly more divergent.
Copyright © 2014 Sijmons et al.
Publication Date: 2014-10-02 PubMed ID: 25278519PubMed Central: PMC4183863DOI: 10.1128/genomeA.00797-14Google Scholar: Lookup
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Summary
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This research article presents the complete genome sequencing of Equid Herpesvirus 3 (EHV-3), an alphaherpesvirinae subfamily member causing equine coital exanthema in horses. The study reveals unusual genetic divergence in the virus, even as it encodes 76 distinct genes, like other equine alphaherpesviruses.
Introduction to EHV-3
- Equid Herpesvirus 3 (EHV-3) is a type of herpesvirus that infects members of the horse family (Equidae) and causes a disease known as equine coital exanthema.
- This disease mostly affects the external genitalia of horses by causing lesions, and thus ultimately leads to infertility.
- EHV-3 is part of the Alphaherpesvirinae subfamily, which contains viruses that typically cause respiratory and reproductive tract diseases in their hosts.
Genome sequencing of EHV-3
- The main focus of this research article was to decode the complete genetic sequence of EHV-3. This is an important step as understanding its genomic structure can help in developing effective diagnostic methods and possible treatments.
- The researchers successfully decoded the 151,601 nucleotide (nt) genome of EHV-3. A genome of this length is typically vast and complex, with its genetic material containing large amounts of information.
- The EHV-3 genome was discovered to encode 76 distinct genes, like other equine alphaherpesviruses, pointing to shared genomic characteristics.
Genetic divergence of EHV-3
- One of the significant findings from the genome sequencing was the considerable genetic divergence of EHV-3. This implies that the EHV-3 genome has significantly and unexpectedly evolved differently from other members of the equine alphaherpesviruses.
- This genetic divergence is likely to impact the pathogenicity, virulence, and behavior of EHV-3 compared to its counterparts. This could mean that this virus might infect, replicate, or spread differently, which could affect the severity of the disease it causes and the way it should be treated.
- An understanding of this divergence can be crucial in devising unique diagnostic tests and treatment options for the disease caused by EHV-3.
Cite This Article
APA
Sijmons S, Vissani A, Tordoya MS, Muylkens B, Thiry E, Maes P, Matthijnssens J, Barrandeguy M, Van Ranst M.
(2014).
Complete genome sequence of equid herpesvirus 3.
Genome Announc, 2(5), e00797-14.
https://doi.org/10.1128/genomeA.00797-14 Publication
Researcher Affiliations
- Laboratory of Clinical Virology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium steven.sijmons@rega.kuleuven.be.
- Instituto de Virología, CICVyA, INTA-Castelar, Buenos Aires, Argentina.
- Instituto de Virología, CICVyA, INTA-Castelar, Buenos Aires, Argentina.
- Veterinary Virology and Animal Viral Diseases, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
- Veterinary Virology and Animal Viral Diseases, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
- Laboratory of Clinical Virology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
- Laboratory of Clinical Virology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
- Instituto de Virología, CICVyA, INTA-Castelar, Buenos Aires, Argentina.
- Laboratory of Clinical Virology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
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Citations
This article has been cited 7 times.- Losinno A, Vissani MA, Sanchez D, Damiani AM. Equid herpesvirus type 3 infection produces membrane-associated and secreted forms of glycoprotein G that are not required for efficient cell-to-cell spread of the virus in vitro.. Arch Virol 2023 Mar 28;168(4):122.
- Troncoso I, Calvanese R, Saravia F, Muñoz-Leal S, Zegpi NA, Ortega R. First molecular detection of Equine Herpesvirus type 3 (EHV-3) in Chile.. Vet Med Sci 2023 Mar;9(2):717-720.
- Vissani MA, Damiani AM, Barrandeguy ME. Equine Coital Exanthema: New Insights on the Knowledge and Leading Perspectives for Treatment and Prevention.. Pathogens 2021 Aug 20;10(8).
- Thorsteinsdóttir L, Guðmundsson GÖ, Jensson H, Torsteinsdóttir S, Svansson V. Isolation of equid alphaherpesvirus 3 from a horse in Iceland with equine coital exanthema.. Acta Vet Scand 2021 Feb 2;63(1):6.
- Câmara RJF, Bueno BL, Resende CF, Balasuriya UBR, Sakamoto SM, Reis JKPD. Viral Diseases that Affect Donkeys and Mules.. Animals (Basel) 2020 Nov 25;10(12).
- Kirisawa R, Toishi Y, Akamatsu A, Soejima K, Miyashita T, Tsunoda N. Isolation of equine herpesvirus 3 (EHV-3) from equine coital exanthema of two stallions and sero-epidemiology of EHV-3 infection in Japan.. J Vet Med Sci 2017 Mar 23;79(3):636-643.
- Negussie H, Li Y, Tessema TS, Nauwynck HJ. Replication characteristics of equine herpesvirus 1 and equine herpesvirus 3: comparative analysis using ex vivo tissue cultures.. Vet Res 2016 Jan 15;47:19.
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