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Microbiology resource announcements2019; 8(48); e01228-19; doi: 10.1128/MRA.01228-19

Complete Genome Sequence of Mycobacterium avium subsp. hominissuis Strain JP-H-1, Isolated from an Equine Abortion Case in Japan.

Abstract: Here, we describe the complete genome assembly of subsp. strain JP-H-1, collected from an equine abortion case in Japan. JP-H-1 has a 5,491,452-bp circular chromosome and 3 plasmids.
Copyright © 2019 Kinoshita et al.
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Publication Date: 2019-11-27 PubMed ID: 31776220PubMed Central: PMC6883107DOI: 10.1128/MRA.01228-19Google Scholar: Lookup
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Summary

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The researchers have sequenced the complete genome of a Mycobacterium avium subsp. hominissuis strain called JP-H-1 that was found in a horse abortion case in Japan. They discovered that JP-H-1 has a circular chromosome that is 5,491,452 base pairs in length as well as three plasmids.

General Overview

  • The article is based on the research conducted to explore the genetic information of the Mycobacterium avium subsp. hominissuis (a type of bacteria) strain JP-H-1. This particular strain was selected due to its isolation from a case of equine abortion in Japan.

Detailed Genome Study

  • The researchers carried out a thorough genome sequencing of Mycobacterium avium subsp. hominissuis, strain JP-H-1. Genome sequencing is a method that is used to determine the complete DNA sequence of an organism’s genome at a single time.
  • Through this procedure, they found out that JP-H-1 boasts a circular chromosome that is 5,491,452 base pairs in length. A chromosome is a long DNA molecule with part or all of the genetic material of an organism, while base pairs are the building blocks of the DNA double helix and contribute to the folding of the DNA into a full bacterial chromosome.

Identification of Plasmids

  • In addition to the circular chromosome, the researchers also identified three plasmids in the Mycobacterium avium subsp. hominissuis strain JP-H-1. Plasmids are small DNA molecules within a cell that are physically separate from chromosomal DNA and can replicate independently, playing a crucial role in the survival and evolution of the bacteria.
  • The identification and study of these plasmids may further aid in understanding the survival mechanisms, virulence, and antibiotic resistance of this particular bacterial strain.

Implication of the Research

  • This exploration of JP-H-1’s genome can provide insights into the genetics, biology, and evolution of the Mycobacterium avium subsp. hominissuis. The information could help in devising new approaches to combat infections caused by this bacterium.
  • Moreover, since this strain was isolated from an equine abortion event, studying it may shed light on what role this bacteria could play in equine health and reproduction and could also help in the development of preventive strategies in the future.

Cite This Article

APA
Kinoshita Y, Niwa H, Uchida-Fujii E, Nukada T. (2019). Complete Genome Sequence of Mycobacterium avium subsp. hominissuis Strain JP-H-1, Isolated from an Equine Abortion Case in Japan. Microbiol Resour Announc, 8(48), e01228-19. https://doi.org/10.1128/MRA.01228-19

Publication

Microbiology resource announcements
ISSN: 2576-098X
NlmUniqueID: 101728794
Country: United States
Language: English
Volume: 8
Issue: 48
PII: e01228-19

Researcher Affiliations

Kinoshita, Yuta
  • Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan kinoshita@equinst.go.jp.
Niwa, Hidekazu
  • Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
Uchida-Fujii, Eri
  • Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
Nukada, Toshio
  • Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.

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This article includes 13 references
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