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Animals : an open access journal from MDPI2020; 10(12); 2268; doi: 10.3390/ani10122268

Concentrations of Circulating Irisin and Myostatin in Race and Endurace Purebred Arabian Horses-Preliminary Study.

Abstract: Skeletal muscle is considered to be the largest endocrine organ determining the maintenance of energy homeostasis. Adaptive changes in skeletal muscles in response to physical exercise influence the production as well as secretion of myokines, which are bioactive factors that play a crucial role in energy expenditure processes. The aim of the study was to investigate the impact of two different types of exercise on the circulating level of two of these, myostatin and irisin, in trained horses. Twenty purebred Arabian horses were involved in the study: 10 three-year-old horses trained on the racetrack and 10 endurance horses aged 7.4 ± 1.9 years. The horses from both groups were regularly trained throughout the entire season, during which they also participated in Polish National competitions. To assess the influence of the training sessions on plasma myostatin and irisin concentrations, blood samples taken at rest and 30 min after the end of exercise were analyzed. In the studied horses, the single bout of exercise did not influence plasma irisin but induced an increase in plasma myostatin concentration. In racehorses, plasma irisin concentration decreased with the length of the training season. Plasma myostatin was higher in endurance horses than in three-year-old racehorses. Lack of exercise-induced fluctuation in circulating irisin in studied horses suggests that myostatin released in response to exercise provides a negative feedback signal to irisin release.
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Publication Date: 2020-12-01 PubMed ID: 33271939PubMed Central: PMC7760310DOI: 10.3390/ani10122268Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses a study undertaken to investigate how two different types of exercise affect the levels of two bioactive factors known as myostatin and irisin in the blood of trained horses. It was found that a single exercise session didn’t affect plasma irisin levels, but did increase plasma myostatin concentration and that myostatin might negatively regulate irisin release.

Study Aim and Design

  • The objective of the study was to investigate how two distinct types of exercise impact the circulating levels of two myokines, myostatin and irisin, in trained Arabian horses. Myokines are bioactive factors that are critical in energy expenditure processes.
  • The study involved 20 purebred Arabian horses: 10 of them three-year-old racehorses and the remaining 10 were endurance horses averaging 7.4 years of age. All the horses were actively trained throughout the entire season and took part in Polish National competitions.

Assessments and Findings

  • To understand the impact of the training sessions on plasma myostatin and irisin concentrations, the researchers analyzed blood samples taken at rest and 30 minutes after the completion of the exercise.
  • The study revealed that a single bout of physical exercise didn’t influence the plasma irisin concentration but led to an increased plasma myostatin concentration.
  • It was also observed that in racehorses, the plasma irisin concentration declined as the length of the training season increased. The plasma myostatin level was higher in endurance horses than in the three-year-old racehorses.

Interpretation and Implications

  • The lack of exercise-induced fluctuations in circulating irisin in the studied horses suggests that the release of myostatin in response to exercise may provide a negative feedback signal for irisin release.
  • The conclusions drawn from this study can count towards understanding the impact of physical exercise on the regulation of energy homeostasis in horses, specifically how different modes of training could trigger differential responses in the release of bioactive factors from skeletal muscles.

Cite This Article

APA
Kowalik S, Wiśniewska A, Kędzierski W, Janczarek I. (2020). Concentrations of Circulating Irisin and Myostatin in Race and Endurace Purebred Arabian Horses-Preliminary Study. Animals (Basel), 10(12), 2268. https://doi.org/10.3390/ani10122268

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 10
Issue: 12
PII: 2268

Researcher Affiliations

Kowalik, Sylwester
  • Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, ul. Akademicka 12, 20-033 Lublin, Poland.
Wiśniewska, Anna
  • Department of Horse Breeding and Use, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, ul. Akademicka 13, 20-950 Lublin, Poland.
Kędzierski, Witold
  • Department of Biochemistry, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, ul. Akademicka 12, 20-033 Lublin, Poland.
Janczarek, Iwona
  • Department of Horse Breeding and Use, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, ul. Akademicka 13, 20-950 Lublin, Poland.

Grant Funding

  • WKF/S/32/2020 / University of Life Sciences in Lublin

Conflict of Interest Statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Citations

This article has been cited 4 times.
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