Concentrations of serum amyloid A and plasma fibrinogen in horses undergoing emergency abdominal surgery.
Abstract: To compare the perioperative response of serum amyloid A (SAA) to fibrinogen in horses requiring exploratory celiotomy for colic and to determine if SAA could be used to predict complications and outcome. Methods: Prospective observational clinical study. Methods: University teaching hospital. Methods: Eighteen horses undergoing exploratory celiotomy for colic. Inclusion criteria for the study included survival and anesthetic recovery from exploratory celiotomy, no history of surgery within the past year. Methods: Blood was obtained via jugular venipuncture before surgery (time 0) and at 24, 48, 72, and 96 hours after recovery from anesthesia. Results: Quantitative and semiquantitative fibrinogen, SAA, total nucleated cell counts, and total protein were evaluated at each time point. Multivariable linear regression was used to assess differences at each time point and after grouping horses according to duration of colic prior to surgery, strangulating surgical lesion or not, presence of systemic inflammatory response syndrome (SIRS) on admission, and postsurgical complications. Significant (P < 0.05) increases in SAA concentrations occurred in all cases after surgery compared to fibrinogen concentration, which only demonstrated a mild, clinically insignificant increase postsurgery. SAA concentrations were also significantly increased (P < 0.05) in cases identified with SIRS prior to surgery and postoperatively at 48 (P = 0.05) and 72 hours (P = 0.02) in horses that developed complications. Conclusions: Measurement of SAA is a more sensitive indicator of inflammation than fibrinogen in the perioperative period of horses requiring exploratory celiotomy for colic. Serial measurement of SAA at 48, 72, and 96 hours after surgery may be helpful to determine risk of complications and guide postoperative management. Measurement of SAA on admission also allows for quantification of SIRS when it is detected clinically.
© Veterinary Emergency and Critical Care Society 2015.
Publication Date: 2015-08-14 PubMed ID: 26274017DOI: 10.1111/vec.12365Google Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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The study examines the response of serum amyloid A (SAA) and fibrinogen in horses undergoing emergency abdominal surgery due to colic, and investigates the potential of SAA as a predictor for post-surgery complications.
Methodology
- The study was carried out in a university teaching hospital and involved 18 horses undergoing exploratory celiotomy (an abdominal surgical procedure) due to colic.
- The inclusion criteria were survival and anesthetic recovery from the surgery, and no history of surgeries within the past year.
- Blood samples were collected from the horses before the surgery and at multiple time intervals (24, 48, 72, and 96 hours) after recovering from anesthesia.
- These samples were then analyzed quantitatively and semi-quantitatively for fibrinogen, SAA, total nucleated cell counts, and total protein at each time point.
- Statistical analysis was performed using multivariable linear regression to assess differences at each time point and after grouping the horses according to parameters including duration of colic before surgery, presence of strangulating surgical lesions, presence of systemic inflammatory response syndrome (SIRS) upon admission, and any post-surgical complications.
Results
- Post-surgery, all horses showed a significant increase in SAA concentrations compared to fibrinogen, the latter only showing a mild increase that was deemed clinically insignificant.
- Increased levels of SAA were also observed at 48 and 72 hours post-surgery in horses that developed complications as well as in those identified with SIRS before surgery.
- In contrast, fibrinogen showed only a mild increase after the surgery, which was considered to be not clinically significant.
Conclusions
- The researchers concluded that SAA is a more sensitive indicator of inflammation than fibrinogen in horses undergoing abdomen surgery needed due to colic.
- They suggest that serial measurements of SAA after surgery might be helpful to determine the risk of complications and guide postoperative management.
- Moreover, measuring SAA on admission can provide a useful quantify of SIRS when it is detected clinically.
Cite This Article
APA
Daniel AJ, Leise BS, Burgess BA, Morley PS, Cloninger M, Hassel DM.
(2015).
Concentrations of serum amyloid A and plasma fibrinogen in horses undergoing emergency abdominal surgery.
J Vet Emerg Crit Care (San Antonio), 26(3), 344-351.
https://doi.org/10.1111/vec.12365 Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523.
- Department of Clinical Sciences, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523.
- Department of Clinical Sciences, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523.
- Department of Clinical Sciences, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523.
- Department of Clinical Sciences, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523.
- Department of Clinical Sciences, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523.
MeSH Terms
- Animals
- Biomarkers / blood
- Blood Chemical Analysis / veterinary
- Cecal Diseases / surgery
- Cecal Diseases / veterinary
- Colic / surgery
- Colic / veterinary
- Female
- Fibrinogen / metabolism
- Horse Diseases / blood
- Horse Diseases / surgery
- Horses
- Male
- Perioperative Period
- Prospective Studies
- Serum Amyloid A Protein / metabolism
- Systemic Inflammatory Response Syndrome / blood
- Systemic Inflammatory Response Syndrome / veterinary
Citations
This article has been cited 8 times.- Blangy-Letheule A, Vergnaud A, Dupas T, Rozec B, Lauzier B, Leroux AA. Spontaneous Sepsis in Adult Horses: From Veterinary to Human Medicine Perspectives.. Cells 2023 Mar 30;12(7).
- Ludwig EK, Hobbs KJ, McKinney-Aguirre CA, Gonzalez LM. Biomarkers of Intestinal Injury in Colic.. Animals (Basel) 2023 Jan 7;13(2).
- Theuerkauf K, Obach-Schröck C, Staszyk C, Moritz A, Roscher KA. Activated platelets and platelet-leukocyte aggregates in the equine systemic inflammatory response syndrome.. J Vet Diagn Invest 2022 May;34(3):448-457.
- Ehrmann C, Engel J, Moritz A, Roscher K. Assessment of platelet biology in equine patients with systemic inflammatory response syndrome.. J Vet Diagn Invest 2021 Mar;33(2):300-307.
- Long A, Nolen-Walston R. Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A.. Vet Clin North Am Equine Pract 2020 Apr;36(1):147-160.
- Witkowska-Piłaszewicz OD, Żmigrodzka M, Winnicka A, Miśkiewicz A, Strzelec K, Cywińska A. Serum amyloid A in equine health and disease.. Equine Vet J 2019 May;51(3):293-298.
- Roy MF, Kwong GP, Lambert J, Massie S, Lockhart S. Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome.. J Vet Intern Med 2017 Mar;31(2):582-592.
- Bauquier JR, Forbes G, Nath L, Tudor E, Bailey SR. Plasma HMGB-1 and Nucleosome Concentrations in Horses with Colic and Healthy Horses.. J Vet Intern Med 2016 Jan-Feb;30(1):260-8.
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