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Reproduction & fertility2022; 3(1); R1-R18; doi: 10.1530/RAF-21-0104

Conception and early pregnancy in the mare: lipidomics the unexplored frontier.

Abstract: Lipids are dynamic biological molecules that play key roles in metabolism, inflammation, cell signalling and structure. They are biologically significant in the physiology of conception and reproduction. Many of the mechanisms surrounding equine conception and the early feto-maternal dialogue are yet to be understood at a biochemical level. Recently, lipidomic technologies have advanced considerably and analytical strategies have been enhanced and diversified. Consequently, in-depth lipidomic exploration now has the potential to reveal new lipid biomarkers and biochemical relationships that improve our understanding of the processes leading to efficient and successful reproduction. This review considers the role of lipids in conception and establishment of pregnancy, providing new insights into the enigmatic pathways governing early reproductive physiology of the mare. This paper discusses the role that lipids play in the very early stages of pregnancy in the mare. Lipids are microscopic non-soluble molecules that are important components of living cells. The manuscript discusses how lipids influence the reproductive cycle of mares, including ovulation and the detailed biological process of becoming pregnant. It explains how lipids are identified in a laboratory setting with a newly developing technology known as 'lipodomics'. The technology may lead to a more detailed understanding of how mares become pregnant. The focus of the paper is on mare reproduction, but it also draws on similarities with reproduction in other mammals. Remarkably there are gaps in much of our knowledge about the finer details of pregnancy in the horse, and the paper summarises what we already know about lipids, highlighting areas for further research.
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Publication Date: 2022-02-18 PubMed ID: 35350651PubMed Central: PMC8956829DOI: 10.1530/RAF-21-0104Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article focuses on the role of lipids in the conception and early stages of pregnancy in mares, utilizing advanced lipidomic technology to explore and potentially discover new biochemical understandings of reproduction processes.

Lipids and Reproduction

  • The paper asserts the vital role of lipids, microscopic non-soluble molecules, in the physiology of conception and reproduction. These dynamic biological molecules are active in cell signalling, structure, inflammatory responses, and metabolism, making them a significant area of study in reproductive processes.
  • According to this article, understanding how lipids factor into the ovulation processes and the biological intricacies of conception could lead to revolutionary findings in the field of reproductive physiology.

Recent Developments in Lipidomics

  • In recent years, there have been substantial advancements in lipidomic technologies, which allow for deeper investigations into lipid biologies. This research involved the use of lipidomic exploration, a technology that can analyze, detect, and identify lipids in a laboratory setting.
  • These enhanced analytical capabilities and diversified strategies could allow researchers to identify new lipid biomarkers relating to conception and reproduction, driving further innovation and understanding in the field.

Brief Understanding of Equine Conception

  • The article draws attention to the many mechanisms of equine conception and the preliminary feto-maternal dialogue that are yet to be fully comprehended at a biochemical level.
  • By investigating the interaction of lipids in these early reproductive stages, the researchers aimed to provide new insights into these “enigmatic pathways” that govern the physiology of equine reproduction.

Future Directions

  • While the central focus of the paper is equine reproduction, the scholars also find connections to reproduction principles across other mammalian species.
  • Despite the progressive understanding of equine pregnancy, there are still significant gaps in the knowledge about the finer details of its processes. This article signifies the key area where lipid research can be prolonged to fill these research gaps, potentially refining the intellect of pregnancy mechanisms in equines in detail.

Cite This Article

APA
Lawson EF, Grupen CG, Baker MA, Aitken RJ, Swegen A, Pollard CL, Gibb Z. (2022). Conception and early pregnancy in the mare: lipidomics the unexplored frontier. Reprod Fertil, 3(1), R1-R18. https://doi.org/10.1530/RAF-21-0104

Publication

Reproduction & fertility
ISSN: 2633-8386
NlmUniqueID: 101778727
Country: England
Language: English
Volume: 3
Issue: 1
Pages: R1-R18

Researcher Affiliations

Lawson, Edwina F
  • Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.
Grupen, Christopher G
  • Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, New South Wales, Australia.
Baker, Mark A
  • Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.
Aitken, R John
  • Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.
Swegen, Aleona
  • Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.
  • Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Pollard, Charley-Lea
  • Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, New South Wales, Australia.
Gibb, Zamira
  • Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.

MeSH Terms

  • Animals
  • Female
  • Fertilization
  • Horses
  • Lipidomics
  • Lipids
  • Mammals
  • Pregnancy
  • Reproduction

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Citations

This article has been cited 3 times.
  1. Perera TRW, Bromfield EG, Gibb Z, Nixon B, Sheridan AR, Rupasinghe T, Skerrett-Byrne DA, Swegen A. Plasma Lipidomics Reveals Lipid Signatures of Early Pregnancy in Mares. Int J Mol Sci 2024 Oct 15;25(20).
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  3. Bazer FW, Johnson GA. Early Embryonic Development in Agriculturally Important Species. Animals (Basel) 2024 Jun 26;14(13).
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