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Home / Equine Research Bank / Equine Vet J / Cone beam computed tomographic myelography in horses with ce...
Equine veterinary journal2025; doi: 10.1111/evj.70094

Cone beam computed tomographic myelography in horses with cervical vertebral compressive myelopathy.

Abstract: While computed tomographic (CT) myelography is increasingly available and has been evaluated in alive horses, objective criteria for diagnosing cervical vertebral compressive myelopathy (CVCM) are lacking. Objective: To establish morphometric dimensions of the cervical vertebral canal and spinal cords from horses with CVCM and compare those to unaffected horses with the use of cone beam CT (CBCT). Methods: Prospective observational study. Methods: Four control horses and ten horses with CVCM underwent diagnostic imaging and histopathology. Morphometric measurements were obtained from cervical radiographs and radiographic and CBCT myelography. Receiver operating characteristic curves were generated to establish thresholds of measurements. Results: Intravertebral sagittal ratios were significantly different between CVCM and control horses. Dorsal myelographic column reduction was significantly different between compressed sites and non-compressed sites. Full myelographic area, dural area, and spinal cord area were significantly smaller in the CVCM horses, and were significantly smaller at compressed sites when compared to non-compressed sites. Reductions of full myelographic area and dural area and ratios of spinal cord area to full myelographic area and dural area were significantly larger at compressed sites when compared to non-compressed sites. Diagnostic thresholds to consider for CVCM are full myelographic area <294 mm, dural area <188 mm, and spinal cord area <104 mm. Compressed sites were associated with thresholds of full myelographic area <274 mm, dural area <188 mm, or reduction of full myelographic area >9%, reduction of dural area >14%, spinal cord area: full myelographic area >36.7%, and spinal cord area: dural area >57.9%. Conclusions: Small number of horses. CVCM horses were younger than control horses. Conclusions: CBCT myelography provides quantitative parameters that can support a diagnosis of CVCM and should be used alongside radiographic myelography.
© 2025 The Author(s). Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.
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Publication Date: 2025-09-18 PubMed ID: 40968581DOI: 10.1111/evj.70094Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

Overview

  • This study aimed to define objective measurements from cone beam computed tomographic (CBCT) myelography to diagnose cervical vertebral compressive myelopathy (CVCM) in horses by comparing morphometric data between affected and unaffected horses.

Background

  • Cervical Vertebral Compressive Myelopathy (CVCM) is a condition in horses causing compression of the spinal cord, leading to neurological symptoms.
  • Computed tomographic (CT) myelography is a diagnostic imaging method increasingly available for live horses to assess spinal cord conditions.
  • Despite the availability of CT myelography, there has been a lack of objective diagnostic criteria to identify CVCM using this imaging technique.
  • Cone beam CT (CBCT) is a form of CT that can provide detailed images with potentially useful morphometric measurements of the spinal canal and cord.

Objective

  • The study aimed to establish quantitative morphometric dimensions of the cervical vertebral canal and spinal cord from horses diagnosed with CVCM.
  • It also sought to compare these measurements to those from unaffected control horses using CBCT myelography.

Methods

  • Design: Prospective observational study involving both control and affected horses.
  • Subjects: Four control horses without neurological issues and ten horses diagnosed with CVCM.
  • Imaging: All horses underwent cervical radiographs and myelography using both radiographic and CBCT methods.
  • Measurements: Morphometric data including intravertebral sagittal ratios, full myelographic area, dural area, spinal cord area, and reduction percentages were collected from the images.
  • Histopathology was used to confirm diagnoses in affected horses.
  • Statistical Analysis: Receiver operating characteristic (ROC) curves were employed to determine diagnostic thresholds of the measurements distinguishing CVCM from normal.

Results

  • Intravertebral sagittal ratios (the proportion of spinal canal size relative to vertebral dimensions) were significantly different between CVCM and control groups, with smaller ratios indicating compression.
  • Dorsal myelographic column reduction (narrowing of the dorsal contrast column in myelography) was significantly more pronounced at compressed sites within affected horses compared to their non-compressed sites.
  • The full myelographic area (entire contrast-filled spinal canal area), dural area (space within the dura mater), and spinal cord area were significantly smaller overall in CVCM horses compared to controls.
  • At localized compressed sites, these areas were further reduced compared to non-compressed sites within the same horse.
  • There were significant reductions in full myelographic and dural areas, along with increased ratios of spinal cord area relative to the full myelographic and dural areas at compressed sites indicating relative spinal cord enlargement or swelling at the site of compression.
  • Diagnostic thresholds identified were:
    • Full myelographic area less than 294 mm²
    • Dural area less than 188 mm²
    • Spinal cord area less than 104 mm²
  • For localized compressed sites within affected horses, thresholds included:
    • Full myelographic area less than 274 mm²
    • Dural area less than 188 mm²
    • Reduction of full myelographic area greater than 9%
    • Reduction of dural area greater than 14%
    • Spinal cord area to full myelographic area ratio greater than 36.7%
    • Spinal cord area to dural area ratio greater than 57.9%
  • CVCM horses in this study tended to be younger than the control horses examined.

Conclusions

  • CBCT myelography provides objective, quantifiable measurements of the cervical spine that differentiate horses with CVCM from unaffected horses.
  • Specific morphometric thresholds derived from this imaging technique support CVCM diagnosis and can be used to identify compressed vertebral sites with neurological involvement.
  • CBCT myelography should be used in conjunction with traditional radiographic myelography for more accurate and quantitative diagnosis of CVCM.
  • The study sample size was relatively small, suggesting further research is needed to validate the thresholds and findings.

Cite This Article

APA
González-Medina S, Barrett MF, Aboellail TA, Nelson BB, Nout-Lomas YS. (2025). Cone beam computed tomographic myelography in horses with cervical vertebral compressive myelopathy. Equine Vet J. https://doi.org/10.1111/evj.70094

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English

Researcher Affiliations

González-Medina, Sonia
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Science, Colorado State University, Fort Collins, Colorado, USA.
Barrett, Myra F
  • Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Science, Colorado State University, Fort Collins, Colorado, USA.
Aboellail, Tawfik A
  • Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Nelson, Bradley B
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Science, Colorado State University, Fort Collins, Colorado, USA.
Nout-Lomas, Yvette S
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Science, Colorado State University, Fort Collins, Colorado, USA.

Grant Funding

  • 2016-05040 / U.S. Department of Agriculture

References

This article includes 29 references
  1. Mayhew IG, deLahunta A, Whitlock RH, Krook L, Tasker JB. Spinal cord disease in the horse.. Cornell Vet 1978;68(Suppl 6): 24–70.
  2. Nout YS, Reed SM. Cervical vertebral stenotic myelopathy.. Equine Vet Educ 2003;15:212–223.
  3. Bonelli MA, da Costa RC. Magnetic resonance imaging and neurologic characterization of combined osseous‐ and disc‐associated cervical spondylomyelopathy in dogs.. J Vet Intern Med 2023;37:1418–1427.
  4. da Costa RC, Parent J, Dobson H, Holmberg D, Partlow G. Comparison of magnetic resonance imaging and myelography in 18 Doberman pinscher dogs with cervical spondylomyelopathy.. Vet Radiol Ultrasound 2006;47:523–531.
  5. Sleutjens J, Cooley AJ, Sampson SN, Wijnberg ID, Back W, van der Kolk JH. The equine cervical spine: comparing MRI and contrast‐enhanced CT images with anatomic slices in the sagittal, dorsal, and transverse plane.. Vet Q 2014;34:74–84.
  6. Mitchell CW, Nykamp SG, Foster R, Cruz R, Montieth G. The use of magnetic resonance imaging in evaluating horses with spinal ataxia.. Vet Radiol Ultrasound 2012;53:613–620.
  7. Janes JG, Garrett KS, McQuerry KJ, Pease AP, Williams NM, Reed SM. Comparison of magnetic resonance imaging with standing cervical radiographs for evaluation of vertebral canal stenosis in equine cervical stenotic myelopathy.. Equine Vet J 2014;46:681–686.
  8. van Biervliet J, Scrivani PV, Divers TJ, Erb HN, de Lahunta A, Nixon A. Evaluation of decision criteria for detection of spinal cord compression based on cervical myelography in horses: 38 cases (1981–2001).. Equine Vet J 2004;36:14–20.
  9. Papageorges M, Gavin PR, Sande RD, Barbee DD, Grant BD. Radiographic and myelographic examination of the cervical vertebral column in 306 ataxic horses.. Vet Radiol 1987;28:53–59.
  10. Levine JM, Scrivani PV, Divers TJ, Furr M, Mayhew IJ, Reed S. Multicenter case‐control study of signalment, diagnostic features, and outcome associated with cervical vertebral malformation‐malarticulation in horses.. J Am Vet Med Assoc 2010;237:812–822.
  11. Estell K, Spriet M, Phillips KL, Aleman M, Finno CJ. Current dorsal myelographic column and dural diameter reduction rules do not apply at the cervicothoracic junction in horses.. Vet Radiol Ultrasound 2018;59:662–666.
  12. Lindgren CMW, Wright L, Kristoffersen M, Puchalski SM. Computed tomography and myelography of the equine cervical spine: 180 cases (2013–2018).. Equine Vet Educ 2021;33:475–483.
  13. Hahn CN, Handel I, Green SL, Bronsvoort MB, Mayhew IG. Assessment of the utility of using intra‐ and intervertebral minimum sagittal diameter ratios in the diagnosis of cervical vertebral malformation in horses.. Vet Radiol Ultrasound 2008;49:1–6.
  14. Moore BR, Holbrook TC, Stefanacci JD, Reed SM, Tate LP, Menard MC. Contrast‐enhanced computed tomography and myelography in six horses with cervical stenotic myelopathy.. Equine Vet J 1992;24:197–202.
  15. Rovel T, Zimmerman M, Duchateau L, Adriaensen E, Mariën T, Saunders JH. Computed tomographic myelography for assessment of the cervical spinal cord in ataxic warmblood horses: 26 cases (2015–2017).. J Am Vet Med Assoc 2021;259:1188–1195.
  16. Kondo T, Sato F, Tsuzuki N, Chen CJ, Yamada K. An objective index for spinal cord compression on computed tomography in Thoroughbred horses.. Vet Med Sci 2022;8:1072–1078.
  17. Kondo T, Sato F, Tsuzuki N, Watanabe K, Horiuchi N, Kobayashi Y. Characteristic computed tomographic myelography findings in 23 Thoroughbred horses.. J Vet Med Sci 2022;84:525–532.
  18. Gough SL, Anderson JDC, Dixon JJ. Computed tomographic cervical myelography in horses: technique and findings in 51 clinical cases.. J Vet Intern Med 2020;34:2142–2151.
  19. Schulze N, Werpy N, Gernhardt J, Fritsch G, Hildebrandt T, Vanderperren K. Dynamic three‐dimensional computed tomographic imaging facilitates evaluation of the equine cervical articular process joint in motion.. Equine Vet J 2023;55:83–91.
  20. Rush Moore B, Reed SM, Biller DS, Moore BR, Kohn CW, Weisbrode SE. Assessment of vertebral canal diameter and bony malformations of the cervical part of the spine in horses with cervical stenotic myelopathy.. Am J Vet Res 1994;55:5–13.
  21. Morishita Y, Naito M, Hymanson H, Miyazaki M, Wu G, Wang JC. The relationship between the cervical spinal canal diameter and the pathological changes in the cervical spine.. Eur Spine J 2009;18:877–883.
  22. DeLahunta A, Glass EN, Kent M. de Lahunta's veterinary neuroanatomy and clinical neurology.. 5th ed. St. Louis, MO: Elsevier Saunders; 2021.
  23. Nouri A, Montejo J, Sun X, Virojanapa J, Kolb LE, Abbed KM. Cervical cord‐canal mismatch: a new method for identifying predisposition to spinal cord injury.. World Neurosurg 2017;108:112–117.
  24. Kondo T, Sato F, Tsuzuki N, Yamada K. Sex differences in cervical spinal cord and spinal canal development in Thoroughbred horses.. J Vet Med Sci 2022;84:1363–1367.
  25. Hejrati N, Pedro K, Alvi MA, Quddusi A, Fehlings MG. Degenerative cervical myelopathy: where have we been? Where are we now? Where are we going?. Acta Neurochir 2023;165:1105–1119.
  26. Powers BE, Stashak TS, Nixon AJ, Yovich JV, Norrdin RW. Pathology of the vertebral column of horses with cervical static stenosis.. Vet Pathol 1986;23:392–399.
  27. Szklarz M, Skalec A, Kirstein K, Janeczek M, Kasparek M, Kasparek A. Management of equine ataxia caused by cervical vertebral stenotic myelopathy: a European perspective 2010–2015.. Equine Vet Educ 2018;30:370–376.
  28. Levine JM, Adam E, MacKay RJ, Walker MA, Frederick JD, Cohen ND. Confirmed and presumptive cervical vertebral compressive myelopathy in older horses: a retrospective study (1992–2004).. J Vet Intern Med 2007;21:812–819.
  29. Lewis MJ. Electrodiagnostic testing in dogs with disorders of the spinal cord or cauda equina.. Vet J 2024;304:106082.

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