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Congenital malignant melanoma in two foals.

Abstract: Two cases of congenital malignant melanomas in horses are described in this report. In each case, wide surgical excision of the mass was performed; no recurrence or metastasis was detected after a minimum of 15 months' follow-up. Melanomas are among the most common neoplasms of horses, but they typically develop in gray horses greater than 6 years old.
Publication Date: 1989-04-01 PubMed ID: 2703431
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Summary

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The research article discusses two unique cases of newborn horses (foals) with skin cancer (malignant melanomas), which were successfully treated with surgery, and showed no signs of cancer recurrence or spreading for at least 15 months.

Context and Relevance

  • The research is important because the condition being studied, malignant melanoma, is a common type of cancer in horses, especially those over the age of six years.
  • However, these cases are peculiar because the horses were newborns (foals), not adults, making these instances of congenital (present at birth) malignant melanomas particularly unusual and worthy of study.

Case Description and Treatment Details

  • The article begins by describing the two unique cases of newborn horses with skin cancer.
  • This is followed by an account of the surgical procedure carried out in each case, which saw the complete removal (wide surgical excision) of the cancerous mass.

Follow-up and Outcomes

  • In documenting the aftermath, the paper details how, upon follow-up 15 months after the surgeries, there were no signs of the cancer coming back (recurrence) or spreading to other parts of the body (metastasis).
  • Given that malignant melanomas are especially prone to recurrence and metastasis, this outcome signifies effective treatment execution and provides a ray of hope for similar future cases.

Implications of the Research

  • This research advances our understanding of malignant melanomas in horses and opens the door to many questions about the nature and treatment of this disease in young horses.
  • Although the sample size is small, the successful result in these isolated cases could lead to more targeted and efficient treatments for congenital malignant melanomas in horses in the future.

Cite This Article

APA
Cox JH, DeBowes RM, Leipold HW. (1989). Congenital malignant melanoma in two foals. J Am Vet Med Assoc, 194(7), 945-947.

Publication

ISSN: 0003-1488
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 194
Issue: 7
Pages: 945-947

Researcher Affiliations

Cox, J H
  • Department of Surgery, College of Veterinary Medicine, Kansas State University, Manhattan 66506.
DeBowes, R M
    Leipold, H W

      MeSH Terms

      • Animals
      • Female
      • Horse Diseases / congenital
      • Horse Diseases / pathology
      • Horse Diseases / surgery
      • Horses
      • Male
      • Melanoma / congenital
      • Melanoma / pathology
      • Melanoma / surgery
      • Melanoma / veterinary
      • Skin Neoplasms / congenital
      • Skin Neoplasms / pathology
      • Skin Neoplasms / surgery
      • Skin Neoplasms / veterinary

      Citations

      This article has been cited 2 times.
      1. Labelle AL, Gemensky Metzler AM, McMullen RJ Jr, Wiggans KT, Labelle P, Hamor RE. Equine intraocular melanocytic neoplasia. Can Vet J 2024 Oct;65(10):1048-1054.
        pubmed: 39355695
      2. Chapman SW, Metzger N, Grest P, Feige K, von Rechenberg B, Auer JA, Hottiger MO. Isolation, establishment, and characterization of ex vivo equine melanoma cell cultures. In Vitro Cell Dev Biol Anim 2009 Mar-Apr;45(3-4):152-62.
        doi: 10.1007/s11626-008-9156-3pubmed: 19057970google scholar: lookup