Continuance of studies on Population S benzimidazole-resistant small strongyles in a Shetland pony herd in Kentucky: effect of pyrantel pamoate (1992-1999).
Abstract: Research on benzimidazole-resistant Population S small strongyles began in a Shetland pony herd in 1974 at the University of Kentucky and has continued for over 25 years. The present update, for the period 1992-1999, evaluated activity of pyrantel pamoate (PRT) in field tests in the pony herd. Additional critical tests with PRT and oxibendazole (OBZ) were done in foals born in the herd. Activity of PRT was initially excellent in field tests, based on epg/lpg count data, but declined rapidly during the second full year of pyrantel treatments. Critical test data for small strongyles indicated efficacies of PRT were about 60% at the beginning of the present observations and this intermediate level of removal continued throughout the seven-year period except for 1994 (75%). Unusual was the finding that field test epg/lpg data on small strongyles indicated much lower activity of PRT than found in worm count data in critical tests. The previously reported ineffective activity of OBZ on this population of small strongyles continued. Data are presented on prevalence and drug activity on several species of internal parasites besides small strongyles.
Publication Date: 2001-01-04 PubMed ID: 11137272DOI: 10.1016/s0304-4017(00)00382-4Google Scholar: Lookup
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- Clinical Trial
- Journal Article
Summary
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This research presents an examination of the use of pyrantel pamoate (PRT) in treating benzimidazole-resistant small strongyles (a type of parasite) in a pony herd in Kentucky over a seven-year period, and notes the initial efficacy and subsequent rapid decline of the treatment.
Background of the Research
- The research forms part of a long-term examination that began in 1974 at the University of Kentucky, looking into the impact of small strongyles parasites that are resistant to treatment with benzimidazole.
- The small strongyles are parasitic worms common in equine systems, which turned out to resist benzimidazole, the common medication.
- To address this resistance, the research sought out alternative treatments such as pyrantel pamoate, also testing oxibendazole (OBZ) in the newborn ponies.
Findings on Pyrantel Pamoate
- According to the study, PRT showed excellent initial effectiveness based on egg per gram/larvae per gram (epg/lpg) count data.
- However, during the second year of pyrantel treatments, the effectiveness of PRT declined sharply.
- Test data from critical tests for small strongyles showed that PRT had about 60% effectiveness at the start of the study, and this intermediate level of effectiveness persisted throughout the seven-year period, peaking slightly in 1994 at 75%.
- Curiously, the field test (epg/lpg) data showed that PRT was significantly less effective than was indicated by the worm count data from critical tests.
Findings on Oxibendazole
- Oxibendazole, another treatment being tested, sustained its previously reported ineffectiveness on the population of small strongyles.
- The research indicates that OBZ was consistently ineffective throughout the duration of the study in combating this particular population of small strongyles.
Additional Findings
- The study also presented data on the prevalence of several species of internal parasites, alongside small strongyles and drug activity on them.
- While the individual effectiveness of the drugs on these various internal parasites was not detailed in the abstract, it’s implied that these findings were included in the full study.
Cite This Article
APA
Lyons ET, Tolliver SC, Drudge JH, Collins SS, Swerczek TW.
(2001).
Continuance of studies on Population S benzimidazole-resistant small strongyles in a Shetland pony herd in Kentucky: effect of pyrantel pamoate (1992-1999).
Vet Parasitol, 94(4), 247-256.
https://doi.org/10.1016/s0304-4017(00)00382-4 Publication
Researcher Affiliations
- Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, 40546-0099, Lexington, KY, USA. elyons1@pop.uky.edu
MeSH Terms
- Animals
- Antinematodal Agents / pharmacology
- Antinematodal Agents / therapeutic use
- Drug Resistance
- Female
- Horses
- Kentucky
- Male
- Pyrantel Pamoate / pharmacology
- Pyrantel Pamoate / therapeutic use
- Strongyle Infections, Equine / drug therapy
- Strongyle Infections, Equine / parasitology
- Strongyloidea / classification
- Strongyloidea / drug effects
- Strongyloidea / isolation & purification
Citations
This article has been cited 5 times.- Johnson ACB, Biddle AS. The Use of Molecular Profiling to Track Equine Reinfection Rates of Cyathostomin Species Following Anthelmintic Administration.. Animals (Basel) 2021 May 9;11(5).
- Bellaw JL, Nielsen MK. Meta-analysis of cyathostomin species-specific prevalence and relative abundance in domestic horses from 1975-2020: emphasis on geographical region and specimen collection method.. Parasit Vectors 2020 Oct 12;13(1):509.
- Hu Y, Miller M, Zhang B, Nguyen TT, Nielsen MK, Aroian RV. In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites.. PLoS Negl Trop Dis 2018 May;12(5):e0006506.
- Molena RA, Peachey LE, Di Cesare A, Traversa D, Cantacessi C. Cyathostomine egg reappearance period following ivermectin treatment in a cohort of UK Thoroughbreds.. Parasit Vectors 2018 Jan 25;11(1):61.
- Lyons E. Population-S benzimidazole- and tetrahydropyrimidine-resistant small strongyles in a pony herd in Kentucky (1977-1999): effects of anthelmintic treatment on the parasites as determined in critical tests.. Parasitol Res 2003 Nov;91(5):407-11.
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