Contribution to the Studies of Coagulogram in Thoroughbred Horses.

The paper sheds light on the ongoing debates around the characteristics and factors related to blood coagulation in Thoroughbred horses, analyzing previous studies to offer insights on the similarities and differences between the coagulation factors in horse and human blood.

Controversies in Blood Coagulation in Horses

• There exists significant controversy in literature regarding blood coagulation phenomenon in horses. These disagreements span over factors like coagulation factors, concentration similarities or differences with humans, and the presence or potential insufficiency of certain factors in horseblood.
• The study provides an overview of various arguments. For instance, authors Soulier and Larricu suggested that the concentration of coagulation factors in horses is similar to humans, while Bell and his team indicated otherwise, opining a notable difference.

Differences in Blood Coagulation Factors

• Bell’s conclusion was further supported by a study conducted by Barkhan and his colleagues.
• On the other hand, Fantl and Marr emphasized that even though there might be a difference in quantity of the thromboplastic factors between humans and horses, their functioning is quite similar.
• Additional support for Bell’s conclusion came from Crecchi and his group who also observed differences in thromboplastic action.

Comparison of Factor V and Prothrombin Complex

• Fantl and Marr found out a greater activity of Factor V in horse blood than in human blood, a point that was not agreed upon by the study conducted by Barkhan and his group.
• The quantity of prothrombin, an important protein present in blood plasma, in normal horse blood is similar to that found in human thrombocytopenic blood according to Fantl and Ward.
• However, the study suggests that horses present a smaller tendency to free phospholipids, indicating a possibility of inadequate number of platelets.

Occurrence of Hemorrhages in Horses

• Despite discussion on different factors and tendencies, it was noted that spontaneous hemorrhages rarely occur in horses. However, the study does mention that horses can suffer from hemophilioid diseases or disorders related to the coagulation processes.