Correction: Pharmacokinetics of intravenous continuous rate infusions of sodium benzylpenicillin and ceftiofur sodium in adult horses.

This research article corrects previously published results regarding the pharmacokinetics of continuous intravenous infusions of two antimicrobial drugs, sodium benzylpenicillin and ceftiofur sodium, in adult horses.

Research Corrections

The corrections emphasis on certain crucial parts of the original study:

• In the initial research, certain rates regarding the continuous rate infusion (CRI) of sodium benzylpenicillin, an antimicrobial medication used in veterinary medicine, were incorrect.
• In both the Abstract and Discussion sections of the initial study, the rate applied for the CRI of sodium benzylpenicillin was incorrect. The correct rate, which has been recalculated and confirmed, should have been 2.5mg/kg/h. This means that for each kilogram of the horse’s weight, 2.5 milligrams of sodium benzylpenicillin should be administered per hour during a continuous rate infusion.
• In the caption for an influencing Figure 2 of the initial study, the rate quoted for the CRI of sodium benzylpenicillin should have been 1.81 mg/kg/h, as opposed to the previously stated rate. This correction affects the interpretation and understanding of the figure, and consequently, the conclusions drawn from it.

Importance of the Corrections

• These corrections are critical because the dosage of drugs in any medical treatment significantly influences the efficacy and safety of the treatment. Incorrect dosages could lead to inadequate or excessive drug concentration in the body, potentially leading to treatment failure or drug toxicity.
• For veterinary medicine, keeping accurate pharmacokinetic data, including drug infusion rates, is particularly important because such data provide guidelines for dosing regimens for different animal species, including different breeds, ages, sizes, and health status. Hence, the accuracy of these numbers directly impacts the welfare and health outcomes of the animals receiving these treatments.
• The data correction models the importance of integrity and rigor in scientific research. When errors are discovered post-publication, it is essential to correct the public scientific record to maintain credibility, avoid the propagation of potentially harmful inaccuracies, and ensure that future studies build upon accurate findings.