Correlation of influenza A virus nucleoprotein genes with host species.
Abstract: The RNAs coding for the nucleoproteins of a panel of influenza isolates from human and nonhuman hosts were compared by RNA-RNA hybridization to determine the extent of genetic diversity of this protein and to determine if related nucleoproteins (NP) are consistently found in viruses from certain hosts. Five nucleoprotein groups were defined. Group 1 contains nearly all of the avian influenza viruses, group 2 includes only certain viruses isolated from gulls, group 3 includes all recent equine influenza strains, group 4 contains only equine/Prague/1/56, and group 5 contains all human and swine influenza isolates. The maintenance of specific nucleoproteins in viruses from certain species suggests that these proteins have evolved functionally significant differences that favor their replication in a specific host.
Publication Date: 1984-03-01 PubMed ID: 6710867DOI: 10.1016/0042-6822(84)90410-0Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The research article investigates the relationship between different types of influenza A virus nucleoproteins and their host species. It suggests that certain nucleoprotein genes are maintained in viruses from specific species, indicating functional differences favoring replication in a specific host.
Objective of the Paper
- The objective of the research was to discover the extent of genetic diversity present in the nucleoproteins of various isolates of the influenza virus. All these isolates were derived from different hosts, both human and non-human.
- Through RNA-RNA hybridization, the goal was to find out whether viruses derived from specific hosts consistently have related nucleoproteins.
Methodology and Findings
- The researchers divided the nucleoproteins into five distinct groups based on the RNA comparison results. Group 1 included almost all avian influenza viruses, group 2 comprised only certain viruses isolated from gulls, group 3 contained all recent equine influenza strains, group 4 contained only equine/Prague/1/56, and group 5 held all human and swine influenza isolates.
- The division into these five groups essentially illustrated the existence of genetic diversity among different hosts and their corresponding virus strains.
Implications of the Findings
- This research implies that specific nucleoproteins are preserved within viruses from particular species. It suggests that these proteins might have undergone an evolution that lead to functional differences, presumably favoring their replication in a specific host,
- Hence, understanding the correlation between the influenza A virus nucleoprotein genes and their host species could be crucial in devising strategies for disease control, as well as in predicting potential host shifts and the resulting disease outbreaks.
Conclusion
- The study provides valuable insights into the connection between the genetic configuration of influenza A viruses and their preferred host species. This understanding could be vital towards our broader comprehension of the influenza virus, its adaptations, and associated diseases.
Cite This Article
APA
Bean WJ.
(1984).
Correlation of influenza A virus nucleoprotein genes with host species.
Virology, 133(2), 438-442.
https://doi.org/10.1016/0042-6822(84)90410-0 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Cell Transformation, Viral
- Genes
- Genes, Viral
- Humans
- Influenza A virus / genetics
- Nucleic Acid Hybridization
- Nucleoproteins / genetics
- RNA, Viral / genetics
- Species Specificity
Grant Funding
- AI-16841 / NIAID NIH HHS
Citations
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