English
French
Targeting eosinophils by active vaccination against interleukin-5 reduces basophil counts in horses with insect bite hypersensitivity in the 2nd year of vaccination
Abstract: Previously, virus-like particle (VLP)-based self-vaccinations targeting interleukin (IL)-5 or IL-31 have been suggested to treat equine insect bite hypersensitivity (IBH), a seasonal recurrent allergic dermatitis in horses. The IL-5-targeting equine vaccine significantly reduced blood eosinophil counts in horses, similar to human monoclonal antibodies targeting IL-5 or the IL-5 receptor alpha (IL-5Rα). Previous studies in humans have also reported an additional effect on reduction of basophil counts. The aim of the present study was to evaluate whether an equine anti-IL-5 vaccine affected blood basophil counts. Horses with IBH were followed in a 3-year trial consisting of a placebo administered in the 1st year, followed by vaccination using an equine (e)IL-5-VLP vaccine in the 2nd and 3rd years. There was a strong reduction in circulating eosinophil counts after vaccination against IL-5. Additionally, there were reduced basophil counts, but only in the 3rd year of the study, suggesting a bystander effect of the anti-IL-5 vaccine on basophil counts.
Publication Date: 2023-09-02 PubMed ID: 37666035DOI: 10.1016/j.tvjl.2023.106027Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Published Erratum
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research reviews an active vaccination against interleukin-5 (IL-5) in horses, utilized to reduce basophil counts in equines with a condition known as insect bite hypersensitivity (IBH). The study, conducted over three years, shows that the vaccine also decreased eosinophil amounts in the blood of horses, indicating it had an additional effect on diminishing basophil levels.
Study Overview
- The focus of this research is the development and analysis of an equine vaccine targeting interleukin (IL)-5, a molecule involved in the immune response.
- Previously, self-vaccinations using virus-like particles (VLPs) presenting IL-5 or IL-31 antigens have been suggested for the treatment of insect bite hypersensitivity (IBH), a seasonal recurrent allergic dermatitis in horses.
Vaccine Effectiveness
- The vaccination trial extended over three years, with horses receiving a placebo in the first year and the IL-5 targeting vaccine in the following two years.
- Similar to human monoclonal antibodies targeting IL-5 or the IL-5 receptor alpha (IL-5Rα), the equine vaccine targeting IL-5 was successful in significantly reducing blood eosinophil counts in horses.
- Eosinophils are a type of white blood cell that play a key role in the body’s immune responses, particularly in combating parasites and in the occurrence of allergic reactions. By reducing their number, the vaccine effectively decreases the inflammatory reaction in horses with IBH.
Bystander Effects of the Vaccine
- Besides reducing eosinophil counts, the study also found that there was a decrease in the number of basophils – another type of white blood cells that play a crucial role in allergic reactions.
- However, this reduction in basophil counts was observed only in the third year of the study, suggesting a bystander effect of the anti-IL-5 vaccine.
- Here, a bystander effect refers to an indirect effect where the vaccination against IL-5, although not directly targeting basophils, nevertheless led to their reduction in number. This finding suggests that suppressing IL-5 seems to non-specifically influence other aspects of the immune response.
Cite This Article
APA
Rhiner T, Fettelschoss V, Schoster A, Birkmann K, Fettelschoss-Gabriel A.
(2023).
Targeting eosinophils by active vaccination against interleukin-5 reduces basophil counts in horses with insect bite hypersensitivity in the 2nd year of vaccination
Vet J, 300-302, 106027.
https://doi.org/10.1016/j.tvjl.2023.106027 Publication
Researcher Affiliations
- Vetsuisse Faculty, Equine Department University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland; Evax AG, Hu00f6rnlistrasse 3, 9542 Mu00fcnchwilen, Switzerland.
- Evax AG, Hu00f6rnlistrasse 3, 9542 Mu00fcnchwilen, Switzerland; University Hospital Zurich, Department of Dermatology, Wagistrasse 18, 8952 Schlieren, Switzerland; Faculty of Medicine, University of Zurich, Switzerland.
- Vetsuisse Faculty, Equine Department University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
- Evax AG, Hu00f6rnlistrasse 3, 9542 Mu00fcnchwilen, Switzerland; Faculty of Medicine, University of Zurich, Switzerland.
- Evax AG, Hu00f6rnlistrasse 3, 9542 Mu00fcnchwilen, Switzerland; University Hospital Zurich, Department of Dermatology, Wagistrasse 18, 8952 Schlieren, Switzerland; Faculty of Medicine, University of Zurich, Switzerland. Electronic address: Antonia.gabriel@usz.ch.
Citations
This article has been cited 0 times.Secure Payments
