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Journal of the American Veterinary Medical Association1996; 209(4); 804-809;

Corynebacterium pseudotuberculosis infection in horses: 538 cases (1982-1993).

Abstract: To describe clinical manifestations of Corynebacterium pseudotuberculosis infection in horses and to evaluate diagnostic methods for identification of this disease. Methods: Retrospective case series. Methods: 538 horses with a diagnosis of C pseudotuberculosis infection. Results: Median age of horses with external abscesses was similar to that in horses with internal abscesses. Breed and sex did not appear to be associated with infection. Cases were detected during all 12 months; however, the disease was most common in the fall and early winter, with the highest incidence in September, October, and November in every year. Most horses (492/538, 91.4%) had a single episode of infection, without recurrence in subsequent years. Of 538 horses, 308 had pectoral abscesses, although infection was documented in many other anatomic locations. Forty-two horses had internal abscesses involving the abdomen or thoracic cavity. Corynebacterium pseudotuberculosis infection was readily identified by bacterial culture of aspirate samples from abscesses. The synergistic hemolysis inhibition test was useful for diagnosis of internal abscesses; however, it was unreliable for the diagnosis of external abscesses. Horses with external abscesses responded well to conventional treatment, in contrast to those with internal abscesses. The overall case fatality was low (3.9%), and was considerably lower for horses with external abscesses (0.8%) than for horses with internal abscesses (40.5%). Conclusions: Serology (synergistic hemolysis inhibition titers > or = 512) is useful for diagnosis of internal abscesses, but not reliable for diagnosis in horses with external abscesses. Prognosis for horses with internal abscesses is considerably poorer than for those with external abscesses.
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Publication Date: 1996-08-15 PubMed ID: 8756884
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about a study on Corynebacterium pseudotuberculosis infection in horses, where 538 cases were analyzed to understand clinical manifestations, evaluate diagnostic methods, and assess factors such as age, breed, sex, and abscess location. The study also evaluated treatment responses and fatality rates.

About the Research

This is a retrospective case series study, which basically refers to a study where medical records for a group of patients with a particular condition (in this case, Corynebacterium pseudotuberculosis infection in horses) are reviewed to study the outcome.

Clinical Manifestations and Factors

  • The study found that the age of the horses with external abscesses was similar to that of the horses with internal abscesses, indicating that age does not play a significant role in the type of abscess formation.
  • Sex and breed of the horses were not associated with the infection.
  • The disease was prevalent throughout the year, but cases escalated in the fall and early winter months, with the highest incidence noted in September, October, and November.
  • Most horses had a single episode of infection with no recurrence in subsequent years.

Abcesses and Infection

  • Out of 538 horses, 308 had pectoral abscesses, but the infection was found in several other anatomic locations as well. Some horses also had internal abscesses involving the abdominal or thoracic cavity.
  • Corynebacterium pseudotuberculosis infection was readily identified by bacterial culture of aspirate samples from abscesses.

Diagnostic Methods

  • The Synergistic Hemolysis Inhibition (SHI) test was a useful tool for diagnosing internal abscesses but proved unreliable for diagnosing external abscesses.
  • Conversely, serology (a diagnostic method that involves testing blood serum) appeared useful for diagnosing internal abscesses but not external ones.

Treatment Response and Fatality

  • Horses with external abscesses responded well to conventional treatment, while those with internal abscesses did not.
  • While the overall case fatality was relatively low (3.9%), horses with internal abscesses had a much higher fatality rate (40.5%) than horses with external abscesses (0.8%).

Conclusions

The study concluded that the prognosis for horses with internal abscesses related to Corynebacterium pseudotuberculosis infection is considerably poorer than those with external abscesses. It also highlighted the importance of serology in diagnosing internal abscesses.

Cite This Article

APA
Aleman M, Spier SJ, Wilson WD, Doherr M. (1996). Corynebacterium pseudotuberculosis infection in horses: 538 cases (1982-1993). J Am Vet Med Assoc, 209(4), 804-809.

Publication

Journal of the American Veterinary Medical Association
ISSN: 0003-1488
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 209
Issue: 4
Pages: 804-809

Researcher Affiliations

Aleman, M
  • Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616, USA.
Spier, S J
    Wilson, W D
      Doherr, M

        MeSH Terms

        • Abscess / diagnosis
        • Abscess / epidemiology
        • Abscess / veterinary
        • Animals
        • Corynebacterium Infections / diagnosis
        • Corynebacterium Infections / epidemiology
        • Corynebacterium Infections / veterinary
        • Corynebacterium pseudotuberculosis / isolation & purification
        • Female
        • Horse Diseases / diagnosis
        • Horse Diseases / epidemiology
        • Horses
        • Incidence
        • Male
        • Recurrence
        • Retrospective Studies
        • Seasons

        Citations

        This article has been cited 21 times.
        1. Rifici C, Attili AR, De Biase D, Gonçalves Dos Santos R, Seyffert N, De Paula Castro TL, Pereira Figueiredo HC, Scaramozzino C, Reale S, Paciello O, Cuteri V, Spier SJ, Azevedo V, Mazzullo G. Atypical Multibacterial Granulomatous Myositis in a Horse: First Report in Italy. Vet Sci 2020 Apr 21;7(2).
          doi: 10.3390/vetsci7020047pubmed: 32326275google scholar: lookup
        2. Ott L. Adhesion properties of toxigenic corynebacteria. AIMS Microbiol 2018;4(1):85-103.
          doi: 10.3934/microbiol.2018.1.85pubmed: 31294205google scholar: lookup
        3. Parise D, Parise MTD, Viana MVC, Muñoz-Bucio AV, Cortés-Pérez YA, Arellano-Reynoso B, Díaz-Aparicio E, Dorella FA, Pereira FL, Carvalho AF, Figueiredo HCP, Ghosh P, Barh D, Gomide ACP, Azevedo VAC. First genome sequencing and comparative analyses of Corynebacterium pseudotuberculosis strains from Mexico. Stand Genomic Sci 2018;13:21.
          doi: 10.1186/s40793-018-0325-zpubmed: 30338024google scholar: lookup
        4. Silva WM, Carvalho RDO, Dorella FA, Folador EL, Souza GHMF, Pimenta AMC, Figueiredo HCP, Le Loir Y, Silva A, Azevedo V. Quantitative Proteomic Analysis Reveals Changes in the Benchmark Corynebacterium pseudotuberculosis Biovar Equi Exoproteome after Passage in a Murine Host. Front Cell Infect Microbiol 2017;7:325.
          doi: 10.3389/fcimb.2017.00325pubmed: 28791255google scholar: lookup
        5. Baraúna RA, Ramos RTJ, Veras AAO, de Sá PHCG, Guimarães LC, das Graças DA, Carneiro AR, Edman JM, Spier SJ, Azevedo V, Silva A. Genomic analysis of four strains of Corynebacterium pseudotuberculosis bv. Equi isolated from horses showing distinct signs of infection. Stand Genomic Sci 2017;12:16.
          doi: 10.1186/s40793-017-0234-6pubmed: 28163825google scholar: lookup
        6. Baraúna RA, Ramos RT, Veras AA, Pinheiro KC, Benevides LJ, Viana MV, Guimarães LC, Edman JM, Spier SJ, Azevedo V, Silva A. Assessing the Genotypic Differences between Strains of Corynebacterium pseudotuberculosis biovar equi through Comparative Genomics. PLoS One 2017;12(1):e0170676.
          doi: 10.1371/journal.pone.0170676pubmed: 28125655google scholar: lookup
        7. Hunyadi L, Sundman EA, Kass PH, Williams DC, Aleman M. Clinical Implications and Hospital Outcome of Immune-Mediated Myositis in Horses. J Vet Intern Med 2017 Jan;31(1):170-175.
          doi: 10.1111/jvim.14637pubmed: 28044365google scholar: lookup
        8. Corbeil LE, Morrissey JF, Léguillette R. Is Corynebacterium pseudotuberculosis infection (pigeon fever) in horses an emerging disease in western Canada?. Can Vet J 2016 Oct;57(10):1062-1066.
          pubmed: 27708444
        9. Mariano DC, Sousa Tde J, Pereira FL, Aburjaile F, Barh D, Rocha F, Pinto AC, Hassan SS, Saraiva TD, Dorella FA, de Carvalho AF, Leal CA, Figueiredo HC, Silva A, Ramos RT, Azevedo VA. Whole-genome optical mapping reveals a mis-assembly between two rRNA operons of Corynebacterium pseudotuberculosis strain 1002. BMC Genomics 2016 Apr 30;17:315.
          doi: 10.1186/s12864-016-2673-7pubmed: 27129708google scholar: lookup
        10. Boysen C, Davis EG, Beard LA, Lubbers BV, Raghavan RK. Bayesian Geostatistical Analysis and Ecoclimatic Determinants of Corynebacterium pseudotuberculosis Infection among Horses. PLoS One 2015;10(10):e0140666.
          doi: 10.1371/journal.pone.0140666pubmed: 26473728google scholar: lookup
        11. Barba M, Stewart AJ, Passler T, Wooldridge AA, van Santen E, Chamorro MF, Cattley RC, Hathcock T, Hogsette JA, Hu XP. Experimental transmission of Corynebacterium pseudotuberculosis biovar equi in horses by house flies. J Vet Intern Med 2015 Mar-Apr;29(2):636-43.
          doi: 10.1111/jvim.12545pubmed: 25818218google scholar: lookup
        12. Rhodes DM, Magdesian KG, Byrne BA, Kass PH, Edman J, Spier SJ. Minimum inhibitory concentrations of equine Corynebacterium pseudotuberculosis isolates (1996-2012). J Vet Intern Med 2015 Jan;29(1):327-32.
          doi: 10.1111/jvim.12534pubmed: 25586790google scholar: lookup
        13. Santos AR, Pereira VB, Barbosa E, Baumbach J, Pauling J, Röttger R, Turk MZ, Silva A, Miyoshi A, Azevedo V. Mature Epitope Density--a strategy for target selection based on immunoinformatics and exported prokaryotic proteins. BMC Genomics 2013;14 Suppl 6(Suppl 6):S4.
          doi: 10.1186/1471-2164-14-S6-S4pubmed: 24564223google scholar: lookup
        14. Hassan SS, Guimarães LC, Pereira Ude P, Islam A, Ali A, Bakhtiar SM, Ribeiro D, Rodrigues Dos Santos A, Soares Sde C, Dorella F, Pinto AC, Schneider MP, Barbosa MS, Almeida S, Abreu V, Aburjaile F, Carneiro AR, Cerdeira LT, Fiaux K, Barbosa E, Diniz C, Rocha FS, Ramos RT, Jain N, Tiwari S, Barh D, Miyoshi A, Müller B, Silva A, Azevedo V. Complete genome sequence of Corynebacterium pseudotuberculosis biovar ovis strain P54B96 isolated from antelope in South Africa obtained by rapid next generation sequencing technology. Stand Genomic Sci 2012 Dec 19;7(2):189-99.
          doi: 10.4056/sigs.3066455pubmed: 23408795google scholar: lookup
        15. Soares SC, Silva A, Trost E, Blom J, Ramos R, Carneiro A, Ali A, Santos AR, Pinto AC, Diniz C, Barbosa EG, Dorella FA, Aburjaile F, Rocha FS, Nascimento KK, Guimarães LC, Almeida S, Hassan SS, Bakhtiar SM, Pereira UP, Abreu VA, Schneider MP, Miyoshi A, Tauch A, Azevedo V. The pan-genome of the animal pathogen Corynebacterium pseudotuberculosis reveals differences in genome plasticity between the biovar ovis and equi strains. PLoS One 2013;8(1):e53818.
          doi: 10.1371/journal.pone.0053818pubmed: 23342011google scholar: lookup
        16. Santos AR, Carneiro A, Gala-García A, Pinto A, Barh D, Barbosa E, Aburjaile F, Dorella F, Rocha F, Guimarães L, Zurita-Turk M, Ramos R, Almeida S, Soares S, Pereira U, Abreu VC, Silva A, Miyoshi A, Azevedo V. The Corynebacterium pseudotuberculosis in silico predicted pan-exoproteome. BMC Genomics 2012;13 Suppl 5(Suppl 5):S6.
          doi: 10.1186/1471-2164-13-S5-S6pubmed: 23095951google scholar: lookup
        17. Cerdeira LT, Schneider MP, Pinto AC, de Almeida SS, dos Santos AR, Barbosa EG, Ali A, Aburjaile FF, de Abreu VA, Guimarães LC, Soares Sde C, Dorella FA, Rocha FS, Bol E, Gomes de Sá PH, Lopes TS, Barbosa MS, Carneiro AR, Jucá Ramos RT, Coimbra NA, Lima AR, Barh D, Jain N, Tiwari S, Raja R, Zambare V, Ghosh P, Trost E, Tauch A, Miyoshi A, Azevedo V, Silva A. Complete genome sequence of Corynebacterium pseudotuberculosis strain CIP 52.97, isolated from a horse in Kenya. J Bacteriol 2011 Dec;193(24):7025-6.
          doi: 10.1128/JB.06293-11pubmed: 22123771google scholar: lookup
        18. Tejedor-Junco MT, Lupiola P, Schulz U, Gutierrez C. Isolation of nitrate-reductase positive Corynebacterium pseudotuberculosis from dromedary camels. Trop Anim Health Prod 2008 Apr;40(3):165-7.
          doi: 10.1007/s11250-007-9077-2pubmed: 18484117google scholar: lookup
        19. Tejedor MT, Martin JL, Corbera JA, Shulz U, Gutierrez C. Pseudotuberculosis in dromedary camels in the Canary Islands. Trop Anim Health Prod 2004 Jul;36(5):459-62.
          doi: 10.1023/b:trop.0000035012.63821.12pubmed: 15449835google scholar: lookup
        20. Connor KM, Quirie MM, Baird G, Donachie W. Characterization of United Kingdom isolates of Corynebacterium pseudotuberculosis using pulsed-field gel electrophoresis. J Clin Microbiol 2000 Jul;38(7):2633-7.
          doi: 10.1128/JCM.38.7.2633-2637.2000pubmed: 10878055google scholar: lookup
        21. Styková E, Valocký I, Kačírová J, Fecskeová LK. Microbiological effect of topically applied Weissella cibaria on equine pastern dermatitis. Front Vet Sci 2024;11:1493756.
          doi: 10.3389/fvets.2024.1493756pubmed: 39834920google scholar: lookup
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