FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Veterinary pathology1978; 15(1); 12-17; doi: 10.1177/030098587801500102

Cryptosporidiosis in immunodeficient Arabian foals.

Abstract: Five of six immunodeficient Arabian foals that died of adenoviral infection were found to be infected with an intestinal coccidian of the genus Cryptosporidium. Various developmental stages of the organism were found in the microvillous border of the intestinal mucosa. The foals had diarrhea but it was not possible to separate the effects of the cryptosporidial infection from those of the concomitant adenoviral enteritis.
Get Full Text
Publication Date: 1978-01-01 PubMed ID: 625861DOI: 10.1177/030098587801500102Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • U.S. Gov't
  • P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study examines the occurrence of Cryptosporidiosis, a parasitic infection, in Arabian foals (young horses) that were immunodeficient and died from an adenoviral infection. The research discovered that out of six foals, five had the Cryptosporidium parasite within their intestinal mucosa.

Background

  • Cryptosporidiosis is a disease caused by a microscopic parasite called Cryptosporidium. This organism infects the intestinal tract and can cause diarrhoea in its host.
  • The study was conducted on Arabian foals, particularly those who are immunodeficient or have a weak immune system, making them vulnerable to infections and diseases.

Findings

  • Out of the six immunodeficient Arabian foals that died of adenoviral infections, five were infected with Cryptosporidium.
  • The different development stages of the Cryptosporidium parasite were found along the microvillous border of the intestinal mucosa in the foals. The microvillous border refers to the small, finger-like extensions that increase the surface area of the intestine, allowing greater nutrient absorption.

Implications

  • In this study, all foals exhibited diarrhoea, a common symptom of Cryptosporidium. However, it was not possible to determine whether the diarrhoea was solely due to the Cryptosporidium infection or if it was a combined effect of the adenoviral infection and the Cryptosporidiosis.
  • The study gives insight into the susceptibility of immunodeficient Arabian foals to parasitic infections. Further research is required to determine the extent to which Cryptosporidium contributes to illness and mortality in this demographic.

Cite This Article

APA
Snyder SP, England JJ, McChesney AE. (1978). Cryptosporidiosis in immunodeficient Arabian foals. Vet Pathol, 15(1), 12-17. https://doi.org/10.1177/030098587801500102

Publication

Veterinary pathology
ISSN: 0300-9858
NlmUniqueID: 0312020
Country: United States
Language: English
Volume: 15
Issue: 1
Pages: 12-17

Researcher Affiliations

Snyder, S P
    England, J J
      McChesney, A E

        MeSH Terms

        • Animals
        • Coccidia / ultrastructure
        • Coccidiosis / complications
        • Coccidiosis / veterinary
        • Horse Diseases / microbiology
        • Horses
        • Immunologic Deficiency Syndromes / complications
        • Immunologic Deficiency Syndromes / veterinary
        • Intestines / microbiology
        • Intestines / ultrastructure

        Citations

        This article has been cited 25 times.
        1. Li XM, Geng HL, Wei YJ, Yan WL, Liu J, Wei XY, Zhang M, Wang XY, Zhang XX, Liu G. Global prevalence and risk factors of Cryptosporidium infection in Equus: A systematic review and meta-analysis. Front Cell Infect Microbiol 2022;12:1072385.
          doi: 10.3389/fcimb.2022.1072385pubmed: 36506009google scholar: lookup
        2. Ghafar A, Abbas G, King J, Jacobson C, Hughes KJ, El-Hage C, Beasley A, Bauquier J, Wilkes EJA, Hurley J, Cudmore L, Carrigan P, Tennent-Brown B, Nielsen MK, Gauci CG, Beveridge I, Jabbar A. Comparative studies on faecal egg counting techniques used for the detection of gastrointestinal parasites of equines: A systematic review. Curr Res Parasitol Vector Borne Dis 2021;1:100046.
          doi: 10.1016/j.crpvbd.2021.100046pubmed: 35284858google scholar: lookup
        3. Couso-Pérez S, de Limia FB, Ares-Mazás E, Gómez-Couso H. First report of zoonotic Cryptosporidium parvum GP60 subtypes IIaA15G2R1 and IIaA16G3R1 in wild ponies from the northern Iberian Peninsula. Parasitol Res 2020 Jan;119(1):249-254.
          doi: 10.1007/s00436-019-06529-xpubmed: 31758296google scholar: lookup
        4. Deng L, Li W, Zhong Z, Gong C, Cao X, Song Y, Wang W, Huang X, Liu X, Hu Y, Fu H, He M, Wang Y, Zhang Y, Wu K, Peng G. Occurrence and Genetic Characteristics of Cryptosporidium hominis and Cryptosporidium andersoni in Horses from Southwestern China. J Eukaryot Microbiol 2017 Sep;64(5):716-720.
          doi: 10.1111/jeu.12399pubmed: 28166378google scholar: lookup
        5. Liu A, Zhang J, Zhao J, Zhao W, Wang R, Zhang L. The first report of Cryptosporidium andersoni in horses with diarrhea and multilocus subtype analysis. Parasit Vectors 2015 Sep 22;8:483.
          doi: 10.1186/s13071-015-1102-0pubmed: 26394848google scholar: lookup
        6. Wagnerová P, Sak B, McEvoy J, Rost M, Matysiak AP, Ježková J, Kváč M. Genetic diversity of Cryptosporidium spp. including novel identification of the Cryptosporidium muris and Cryptosporidium tyzzeri in horses in the Czech Republic and Poland. Parasitol Res 2015 Apr;114(4):1619-24.
          doi: 10.1007/s00436-015-4353-ypubmed: 25722018google scholar: lookup
        7. Gajadhar AA, Caron JP, Allen JR. Cryptosporidiosis in two foals. Can Vet J 1985 Apr;26(4):132-4.
          pubmed: 17422522
        8. Majewska AC, Solarczyk P, Tamang L, Graczyk TK. Equine Cryptosporidium parvum infections in western Poland. Parasitol Res 2004 Jul;93(4):274-8.
          doi: 10.1007/s00436-004-1111-ypubmed: 15156396google scholar: lookup
        9. Granstrom DE. Recent advances in the laboratory diagnosis of equine parasitic diseases. Vet Clin North Am Equine Pract 1995 Dec;11(3):437-42.
          doi: 10.1016/s0749-0739(17)30309-7pubmed: 8925419google scholar: lookup
        10. Guarino A, Canani RB, Pozio E, Terracciano L, Albano F, Mazzeo M. Enterotoxic effect of stool supernatant of Cryptosporidium-infected calves on human jejunum. Gastroenterology 1994 Jan;106(1):28-34.
          doi: 10.1016/s0016-5085(94)94093-2pubmed: 8276202google scholar: lookup
        11. Xiao L, Herd RP. Review of equine Cryptosporidium infection. Equine Vet J 1994 Jan;26(1):9-13.
          doi: 10.1111/j.2042-3306.1994.tb04322.xpubmed: 8143674google scholar: lookup
        12. Tzipori S, Angus KW, Campbell I, Gray EW. Cryptosporidium: evidence for a single-species genus. Infect Immun 1980 Dec;30(3):884-6.
          doi: 10.1128/iai.30.3.884-886.1980pubmed: 7228392google scholar: lookup
        13. Pearson GR, Logan EF, McNulty MS. Distribution of cryptosporidia within the gastrointestinal tract of young calves. Res Vet Sci 1982 Sep;33(2):228-31.
          doi: 10.1016/S0034-5288(18)32341-5pubmed: 7146631google scholar: lookup
        14. Tzipori S, Campbell I. Prevalence of Cryptosporidium antibodies in 10 animal species. J Clin Microbiol 1981 Oct;14(4):455-6.
          doi: 10.1128/jcm.14.4.455-456.1981pubmed: 7026613google scholar: lookup
        15. Tzipori S. Cryptosporidiosis in animals and humans. Microbiol Rev 1983 Mar;47(1):84-96.
          doi: 10.1128/mr.47.1.84-96.1983pubmed: 6343828google scholar: lookup
        16. Angus KW. Cryptosporidiosis in man, domestic animals and birds: a review. J R Soc Med 1983 Jan;76(1):62-70.
          doi: 10.1177/014107688307600114pubmed: 6338228google scholar: lookup
        17. Anderson BC. Moist heat inactivation of Cryptosporidium sp. Am J Public Health 1985 Dec;75(12):1433-4.
          doi: 10.2105/ajph.75.12.1433pubmed: 4061720google scholar: lookup
        18. Palmer JE. Gastrointestinal diseases of foals. Vet Clin North Am Equine Pract 1985 Apr;1(1):151-68.
          doi: 10.1016/s0749-0739(17)30774-5pubmed: 3907766google scholar: lookup
        19. Rodgers VD, Kagnoff MF. Gastrointestinal manifestations of the acquired immunodeficiency syndrome. West J Med 1987 Jan;146(1):57-67.
          pubmed: 3825111
        20. Riggs MW, Perryman LE. Infectivity and neutralization of Cryptosporidium parvum sporozoites. Infect Immun 1987 Sep;55(9):2081-7.
          doi: 10.1128/iai.55.9.2081-2087.1987pubmed: 3623693google scholar: lookup
        21. Fayer R, Ungar BL. Cryptosporidium spp. and cryptosporidiosis. Microbiol Rev 1986 Dec;50(4):458-83.
          doi: 10.1128/mr.50.4.458-483.1986pubmed: 3540573google scholar: lookup
        22. Tzipori S. Cryptosporidiosis in perspective. Adv Parasitol 1988;27:63-129.
          doi: 10.1016/s0065-308x(08)60353-xpubmed: 3289331google scholar: lookup
        23. Perryman LE, Riggs MW, Mason PH, Fayer R. Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum. Infect Immun 1990 Jan;58(1):257-9.
          doi: 10.1128/iai.58.1.257-259.1990pubmed: 2294054google scholar: lookup
        24. Bjorneby JM, Leach DR, Perryman LE. Persistent cryptosporidiosis in horses with severe combined immunodeficiency. Infect Immun 1991 Oct;59(10):3823-6.
          doi: 10.1128/iai.59.10.3823-3826.1991pubmed: 1894380google scholar: lookup
        25. Farid A, Aiad S, Safwat G. Anti-Cryptosporidium oocysts polyclonal antibodies for cryptosporidiosis diagnosis and protection. AMB Express 2023 Nov 9;13(1):125.
          doi: 10.1186/s13568-023-01632-wpubmed: 37943403google scholar: lookup
        Subscribe to our newsletter
        Join 99,727 horse owners like you who receive our email updates on horse health and nutrition.