Cutaneous asthenia in a Warmblood foal.
Abstract: A 6-week-old Warmblood colt foal was presented for investigation of multiple haematoma formation in various locations, poor wound healing and abnormal scar formation. Based on the history and clinical presentation of hyperextensible skin with prolonged skin tenting, the foal was diagnosed with cutaneous asthenia and euthanased because of the poor prognosis. Histopathological and electron microscopic findings were inconclusive. This is the first case report of cutaneous asthenia in a Warmblood horse in Australia. Cutaneous asthenia is reviewed with particular reference to hereditary equine regional dermal asthenia and its similarities and differences to the case presented.
© 2011 The Authors. Australian Veterinary Journal © 2011 Australian Veterinary Association.
Publication Date: 2011-02-18 PubMed ID: 21323653DOI: 10.1111/j.1751-0813.2010.00683.xGoogle Scholar: Lookup
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Summary
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This research highlights a case of a 6-week-old Warmblood foal in Australia who was diagnosed with cutaneous asthenia (a skin condition characterized by hyperextensible skin and poor wound healing) after presenting multiple haematomas and abnormal scar formations. The study elaborates on the specifics related to the diagnosis and the similarities and differences with the hereditary equine regional dermal asthenia.
Clinical Presentation and Diagnosis
- The Warmblood foal in question was brought for examination due to multiple formations of haematomas in different locations on its body. The foal was also unable to heal wounds adequately and developed abnormal scar formations.
- These symptoms led to the diagnosis of cutaneous asthenia, a skin disorder characterized by skin hyperextensibility or the excessive elasticity of the skin, along with high tearability and abnormal scarring.
- The skin was hyperextensible and noted prolonged skin tenting which supports evidence of cutaneous asthenia. Despite additional histopathological and electron microscopic tests, the findings were inconclusive.
Euthanisation and Prognosis
- The severity and complications associated with the diagnosed condition led to the unfortunate decision of euthanising the foal, mainly due to the poor prognosis and compromised quality of life ahead.
- Prognosis for cases such as this is often bleak, given the extreme fragility of the skin and the complications arising from even minor injuries.
Importance of Case and Further Discussions
- This represented the first ever reported case of its kind in Australia involving a Warmblood horse breed. Thus making it unique and beneficial for further research and understanding within the equine veterinary community in Australia and globally.
- The presented case also sparks deeper discussions on cutaneous asthenia, particularly looking at its association with hereditary equine regional dermal asthenia (HERDA), a similar condition seen in certain equine breeds.
- While the exact relationship and differences between the two conditions remain to be fully understood, this case opens research avenues for in-depth study into these skin disorders among equines.
Cite This Article
APA
Marshall VL, Secombe C, Nicholls PK.
(2011).
Cutaneous asthenia in a Warmblood foal.
Aust Vet J, 89(3), 77-81.
https://doi.org/10.1111/j.1751-0813.2010.00683.x Publication
Researcher Affiliations
- Murdoch University Veterinary Hospital, School of Veterinary Medicine, Murdoch University, Murdoch, Western Australia 6150, Australia. vickym83@hotmail.com
MeSH Terms
- Animals
- Animals, Newborn
- Asthenia / diagnosis
- Asthenia / genetics
- Asthenia / veterinary
- Euthanasia, Animal
- Genetic Predisposition to Disease
- Horse Diseases / diagnosis
- Horse Diseases / genetics
- Horses
- Male
- Pedigree
- Prognosis
Citations
This article has been cited 6 times.- Ablondi M, Johnsson M, Eriksson S, Sabbioni A, Viklund ÅG, Mikko S. Performance of Swedish Warmblood fragile foal syndrome carriers and breeding prospects. Genet Sel Evol 2022 Jan 21;54(1):4.
- Rowe Á, Flanagan S, Barry G, Katz LM, Lane EA, Duggan V. Warmblood fragile foal syndrome causative single nucleotide polymorphism frequency in horses in Ireland. Ir Vet J 2021 Oct 18;74(1):27.
- Reiter S, Wallner B, Brem G, Haring E, Hoelzle L, Stefaniuk-Szmukier M, Długosz B, Piórkowska K, Ropka-Molik K, Malvick J, Penedo MCT, Bellone RR. Distribution of the Warmblood Fragile Foal Syndrome Type 1 Mutation (PLOD1 c.2032G>A) in Different Horse Breeds from Europe and the United States. Genes (Basel) 2020 Dec 18;11(12).
- Bellone RR, Ocampo NR, Hughes SS, Le V, Arthur R, Finno CJ, Penedo MCT. Warmblood fragile foal syndrome type 1 mutation (PLOD1 c.2032G>A) is not associated with catastrophic breakdown and has a low allele frequency in the Thoroughbred breed. Equine Vet J 2020 May;52(3):411-414.
- Hansen N, Foster SF, Burrows AK, Mackie J, Malik R. Cutaneous asthenia (Ehlers-Danlos-like syndrome) of Burmese cats. J Feline Med Surg 2015 Nov;17(11):954-63.
- Monthoux C, de Brot S, Jackson M, Bleul U, Walter J. Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome. BMC Vet Res 2015 Jan 31;11:12.
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