(D)-Ribose supplementation in the equine: lack of effect on glycated plasma proteins suggesting safety in humans.

This research article investigates the safety of d-Ribose, a dietary supplement, in thoroughbred racehorses and suggests potential benefits for humans. The study found that long-term d-Ribose consumption at moderate levels did not cause formation of harmful glycated proteins and offered protection against muscle cramps while enhancing recovery.

Purpose and Background of the Study

• The study aimed to investigate whether consumption of d-Ribose, a common nutritional supplement known for its vital role in cellular bioenergetics, would cause formation of glycated proteins in vivo. These proteins can have potential adverse effects on health.

Methodology

• Two distinct groups of thoroughbred racehorses were included in the study. These horses were provided with different daily quantities (30 and 50 grams) of d-Ribose supplement for a period of 17 weeks.
• Throughout the study period, the horses were subjected to varying exercise regimens, starting with low-intensity and gradually moving to high-intensity workouts.
• Blood samples were taken before and after the different exercise regimens to measure the levels of glycated plasma proteins.

Findings

• The study found that regular consumption of d-Ribose in the given amounts did not promote the creation of glycated plasma proteins in the horses.
• Additionally, the supplement appeared to provide protection against muscle cramps while promoting faster muscle recovery, with no reported adverse effects.

Conclusions and Implications

• The study concludes that d-Ribose supplementation is safe as it does not induce glycation in vivo.
• These findings assert the safety of d-Ribose in thoroughbred racehorses, suggesting that this might be applicable to humans as well. Thus, the research suggests potential benefits for d-Ribose supplementation in humans.