Defining the Systemic Inflammatory Response Syndrome in Equine Neonates.
Abstract: Defining and describing the systemic inflammatory response syndrome (SIRS) and sepsis facilitated recognition and investigation of the complex disease processes involving the host response to infection and trauma. Over the years a variety of definitions of SIRS have been examined and applied to numerous research studies to improve critical care in both human and veterinary clinical practice. This article summarizes the history of the development of the SIRS definition, outlines the pathophysiologic processes that are involved in SIRS, and provides a specific definition for use in foal medicine.
Copyright © 2015 Elsevier Inc. All rights reserved.
Publication Date: 2015-11-28 PubMed ID: 26612743DOI: 10.1016/j.cveq.2015.08.001Google Scholar: Lookup
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Summary
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This research paper discusses the Systemic Inflammatory Response Syndrome (SIRS) in newborn horses (foals), detailing its definition, the history of its development, and the involved pathophysiological processes.
History of the SIRS Definition
- The article traces the history of the definition of the Systemic Inflammatory Response Syndrome (SIRS). Over the years, various definitions of SIRS have been examined and used in multiple research studies with the aim of improving critical care in both veterinary and human medicine.
Pathophysiologic Processes of SIRS
- Another significant part of this research paper is devoted to exploring the pathophysiological processes that are involved in SIRS. SIRS is a response to infection or trauma and involves a host of complex disease processes. Elucidating these processes aids in comprehending the origination and development of the syndrome.
SIRS Definition in Foal Medicine
- The study provides a specific definition of SIRS for use in foal medicine. The investigative focus on foals contributes to the nuance and peculiarities of this syndrome in newborn horses. The authors acknowledge that while SIRS has often been the subject of human and general veterinary studies, the unique manifestations and characteristics of this syndrome in equine neonates necessitates a specific definition. This can pave the way for targeted therapeutic interventions and promote better care for foals exhibiting signs of SIRS.
Cite This Article
APA
Wong DM, Wilkins PA.
(2015).
Defining the Systemic Inflammatory Response Syndrome in Equine Neonates.
Vet Clin North Am Equine Pract, 31(3), 463-481.
https://doi.org/10.1016/j.cveq.2015.08.001 Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University, Ames, IA 50036, USA. Electronic address: DWONG@IASTATE.EDU.
- Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
MeSH Terms
- Animals
- Animals, Newborn
- Critical Care
- Horse Diseases / diagnosis
- Horse Diseases / pathology
- Horses
- Sepsis
- Systemic Inflammatory Response Syndrome / diagnosis
- Systemic Inflammatory Response Syndrome / pathology
- Systemic Inflammatory Response Syndrome / veterinary
Citations
This article has been cited 14 times.- Laurberg M, Saegerman C, Jacobsen S, Berg LC, Laursen SH, Hoeberg E, Sånge EA, van Galen G. Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals. PLoS One 2023;18(5):e0285819.
- Bookbinder LC, Mani R, Carr EA. Antibiograms of field and hospital acquired equine neonatal bacterial fluid cultures in the Midwestern United States: 149 samples (2007-2018). J Vet Intern Med 2023 May-Jun;37(3):1193-1200.
- Hoeberg E, Sånge A, Saegerman C, Bohlin A, Nostell K, Durie I, Husted L, Öhman A, Jacobsen S, Berg L, Laursen SH, van Galen G. Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals. J Vet Intern Med 2022 Nov;36(6):2245-2253.
- Lanci A, Benedetti B, Freccero F, Castagnetti C, Mariella J, van Loon JPAM, Padalino B. Development of a Composite Pain Scale in Foals: A Pilot Study. Animals (Basel) 2022 Feb 11;12(4).
- Freccero F, Lanci A, Mariella J, Viciani E, Quercia S, Castagnetti A, Castagnetti C. Changes in the Fecal Microbiota Associated with a Broad-Spectrum Antimicrobial Administration in Hospitalized Neonatal Foals with Probiotics Supplementation. Animals (Basel) 2021 Aug 2;11(8).
- Vitale V, Berg LC, Larsen BB, Hannesdottir A, Dybdahl Thomsen P, Laursen SH, Verwilghen D, van Galen G. Blood glucose and subcutaneous continuous glucose monitoring in critically ill horses: A pilot study. PLoS One 2021;16(2):e0247561.
- Sanmartí J, Armengou L, Viu J, Alguacil E, Civit S, Ríos J, Jose-Cunilleras E. Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals. J Vet Intern Med 2020 May;34(3):1325-1331.
- Bohlin A, Saegerman C, Hoeberg E, Sånge A, Nostell K, Durie I, Husted L, Öhman A, van Galen G. Evaluation of the foal survival score in a Danish-Swedish population of neonatal foals upon hospital admission. J Vet Intern Med 2019 May;33(3):1507-1513.
- Sheats MK. A Comparative Review of Equine SIRS, Sepsis, and Neutrophils. Front Vet Sci 2019;6:69.
- Wong DM, Ruby RE, Dembek KA, Barr BS, Reuss SM, Magdesian KG, Olsen E, Burns T, Slovis NM, Wilkins PA. Evaluation of updated sepsis scoring systems and systemic inflammatory response syndrome criteria and their association with sepsis in equine neonates. J Vet Intern Med 2018 May;32(3):1185-1193.
- Roy MF, Kwong GP, Lambert J, Massie S, Lockhart S. Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome. J Vet Intern Med 2017 Mar;31(2):582-592.
- Chen LT, Wesdorp E, Jager M, Siegers EW, Theelen MJP, Besselink N, Vermeulen C, Zomer AL, Broens EM, Wagenaar JA, de Ridder J. Bacterial cell-free DNA profiling reveals the co-elevation of multiple bacteria in newborn foals with suspected sepsis. iScience 2025 Dec 19;28(12):114005.
- Mendoza FJ, Toribio RE. An Overview of Donkey Neonatology. Animals (Basel) 2025 Jul 6;15(13).
- Bernick A, Krohn J, Wehrend A. Patent Urachus and Associated Comorbidities in 101 Newborn Foals: A Retrospective Study. Vet Med Sci 2025 May;11(3):e70379.
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