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Dermatologic tumors (excluding sarcoids).
Abstract: Cutaneous neoplasia represents a clinical problem with which veterinarians are commonly challenged. This article addresses equine cutaneous squamous cell carcinoma, squamous cell papilloma, melanoma, mastocytosis, and lymphosarcoma. Current concepts regarding the origin, pathogenesis, diagnosis and treatment of each neoplasm is emphasized.
Publication Date: 1999-01-19 PubMed ID: 9891728DOI: 10.1016/s0749-0739(17)30190-6Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article provides an in-depth study of various types of skin tumors, excluding sarcoids, in horses and presents recent developments in their origin, diagnosis, and treatment.
Understanding Cutaneous Neoplasia in Horses
- This research primarily revolves around cutaneous neoplasia, a type of skin cancer quite prevalent in horses. This condition particularly tends to appear in areas where the skin is white or lightly pigmented, and exposure to sunlight is high.
- The researchers address various forms of this condition such as squamous cell carcinoma, squamous cell papilloma, melanoma, mastocytosis, and lymphosarcoma. Each of these neoplasms varies in its severity, rate of growth, and response to treatment.
Origin and Pathogenesis of Neoplasms
- The research discusses the origins and pathogenesis of each of these conditions. It typically understanding that the development of skin cancer is often associated with excessive exposure to ultraviolet radiation from the sun, genetic predispositions, and certain viral infections.
- For example, equine cutaneous squamous cell carcinoma often originates from keratinocytes – cells forming the outer layer of the skin, while melanoma arises from melanosomes, which are pigment cells.
Diagnosis Methods
- When it comes to diagnosis, the effectiveness of methods tends to vary depending on the type of neoplasm. The consensus generally agreed on in this research is that early detection can significantly enhance the likelihood of successful treatment.
- Biopsy is one common diagnostic technique employed to confirm the presence and type of cancer. Advanced imaging technologies such as CT scans and MRI might be used in cases where the tumor’s infiltration and spread need to be assessed.
Insights into Treatment
- Finally, the article provides insights into the current treatment methods of each of these neoplasms. The right treatment varies on the type and stage of the cancer, localisation of the tumor, and the general health condition of the horse.
- The treatment often involves a combination of surgery (to remove the tumors), radiation therapy, chemotherapy, or immunotherapy. New therapies involving laser treatment or targeted therapies might also offer promising results.
Significance of the Study
- This research plays a vital role in providing an overview of the common dermatological tumors in horses. It not only provides insights into the origin, diagnosis, and treatment of these conditions but also sets the direction for future research and development of novel therapies.
- This comprehensive information supports veterinarians in their decision-making process concerning the appropriate diagnosis and treatment procedures.
Cite This Article
APA
Johnson PJ.
(1999).
Dermatologic tumors (excluding sarcoids).
Vet Clin North Am Equine Pract, 14(3), 625-viii.
https://doi.org/10.1016/s0749-0739(17)30190-6 Publication
Researcher Affiliations
- Veterinary Medical Teaching Hospital, College of Veterinary Medicine, University of Missouri, Columbia, USA.
MeSH Terms
- Animals
- Carcinoma, Squamous Cell / diagnosis
- Carcinoma, Squamous Cell / therapy
- Carcinoma, Squamous Cell / veterinary
- Horse Diseases / diagnosis
- Horse Diseases / etiology
- Horse Diseases / therapy
- Horses
- Lymphoma, Non-Hodgkin / diagnosis
- Lymphoma, Non-Hodgkin / therapy
- Lymphoma, Non-Hodgkin / veterinary
- Mastocytosis / diagnosis
- Mastocytosis / therapy
- Mastocytosis / veterinary
- Melanoma / diagnosis
- Melanoma / therapy
- Melanoma / veterinary
- Papilloma / diagnosis
- Papilloma / therapy
- Papilloma / veterinary
- Papillomaviridae
- Papillomavirus Infections / diagnosis
- Papillomavirus Infections / therapy
- Papillomavirus Infections / veterinary
- Skin Neoplasms / diagnosis
- Skin Neoplasms / etiology
- Skin Neoplasms / therapy
- Skin Neoplasms / veterinary
- Tumor Virus Infections / diagnosis
- Tumor Virus Infections / therapy
- Tumor Virus Infections / veterinary
References
This article includes 218 references
Citations
This article has been cited 19 times.- Tesena P, Vinijkumthorn R, Kingkaw A, Yanyongsirikarn P, Phasuk K, Ploypetch S, Phaonakrop N, Roytrakul S, Vongsangnak W, Prapaiwan N. Probing Wnt pathway and functional signal in equine melanocytic neoplasms through quantitative proteomics and immunohistochemistry. BMC Vet Res 2025 Aug 7;21(1):509.
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- Pimenta J, Prada J, Pires I, Cotovio M. The Impact of Excision Interval on Equine Melanoma Progression: Time Matters?. Animals (Basel) 2024 Apr 22;14(8).
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- Pimenta J, Prada J, Cotovio M. Equine Melanocytic Tumors: A Narrative Review. Animals (Basel) 2023 Jan 10;13(2).
- Weber LA, Delarocque J, Feige K, Kietzmann M, Kalbitz J, Meißner J, Paschke R, Cavalleri JV. Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses. Animals (Basel) 2021 Nov 13;11(11).
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