Deslorelin acetate (Ovuplant) therapy in cycling mares: effect of implant removal on FSH secretion and ovarian function.

The study explores the impact of deslorelin acetate (Ovuplant) therapy on the ovarian function and FSH secretion in mares. It particularly investigates whether removing the implant after 2 days could prevent the decrease in gonadotrophin concentrations and follicular growth, and it is found that such removal mitigates the negative impacts associated with implant administration.

Methodology

• Twenty-four mares were randomly divided into three groups for the study. While Group 1 was allowed to ovulate spontaneously, Groups 2 and 3 were given deslorelin implant to induce ovulation.
• Two days post this treatment, the implant was removed from the mares in Group 3.

Findings

• On the 10th day after ovulation, it was observed that FSH was lower in Group 2, indicating a decrease in gonadotrophin concentrations. However, there was no difference between the FSH levels of Groups 1 and 3.
• The diameter of follicular growth on Day 14 was smaller in Group 2 in comparison to Groups 1 and 3. These readings suggest that the presence of the deslorelin implant slows down follicular growth.
• An extended interovulatory interval was found in Group 2, compared to Groups 1 and 3, suggesting that deslorelin implant allows for a longer period between ovulations.

Conclusion

• The study concluded that the removal of the deslorelin implant after 2 days of administration effectively prevents a decrease in the secretion of FSH and the growth of follicles, consequently reducing the interovulatory interval in mares.
• The impact of deslorelin implant on ovarian function suggests its ability to control equine reproductive cycles. Thus, removing the implant after detecting ovulation is recommended to avoid prolonged periods between ovulations.