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Home / Equine Research Bank / Vector Borne Zoonotic Dis / Detection of antibodies to West Nile virus in horses, Costa ...
Vector borne and zoonotic diseases (Larchmont, N.Y.)2011; 11(8); 1081-1084; doi: 10.1089/vbz.2010.0198

Detection of antibodies to West Nile virus in horses, Costa Rica, 2004.

Abstract: We conducted a serosurvey for West Nile virus (WNV) infection in equines in Costa Rica in 2004. Antibodies to WNV were detected in 28% of the horses using an epitope blocking ELISA that is specific for WNV. WNV infection was confirmed for a subset of these sera by plaque reduction neutralization tests and Western blot. This is the first evidence of WNV activity in Costa Rica.
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Publication Date: 2011-03-21 PubMed ID: 21417920DOI: 10.1089/vbz.2010.0198Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about a study conducted in 2004 that found antibodies to West Nile virus (WNV) in 28% of the tested horses in Costa Rica. This suggests the presence of the virus in the country.

Research Background

  • The study investigates the presence of West Nile virus (WNV) in Costa Rica, a country where the virus had not previously been identified.
  • West Nile virus is a mosquito-borne zoonotic disease, which means it can be transmitted between animals and humans. The primary hosts of the virus are birds, but it can infect other species such as horses and humans.

Methodology

  • The researchers decided to conduct a serosurvey, a survey to identify the presence of specific antibodies in the blood serum resulting from past or present infection.
  • The serosurvey was conducted in 2004 targeting horses in Costa Rica.
  • The researchers used a testing method called an epitope blocking ELISA (enzyme-linked immunosorbent assay), which is designed to detect antibodies specific to WNV.

Findings

  • The study found that 28% of the tested horses had antibodies to WNV, indicating that they had been infected with the virus at some point.
  • The researchers used additional testing methods, including plaque reduction neutralization tests and western blot, to confirm the presence of WNV infection in some of the serum samples.

Conclusion

  • The detection of these antibodies was the first evidence of WNV activity in Costa Rica.
  • This established the existence of the disease in this region and highlighted the importance of further research and surveillance for managing and controlling the disease in the country.

Cite This Article

APA
Hobson-Peters J, Arévalo C, Cheah WY, Blitvich BJ, Tan CS, Sandis A, Araya LN, Hernández JL, Toye P, Hall RA. (2011). Detection of antibodies to West Nile virus in horses, Costa Rica, 2004. Vector Borne Zoonotic Dis, 11(8), 1081-1084. https://doi.org/10.1089/vbz.2010.0198

Publication

Vector borne and zoonotic diseases (Larchmont, N.Y.)
ISSN: 1557-7759
NlmUniqueID: 100965525
Country: United States
Language: English
Volume: 11
Issue: 8
Pages: 1081-1084

Researcher Affiliations

Hobson-Peters, Jody
  • Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia.
Arévalo, Carolina
    Cheah, Wai Yuen
      Blitvich, Bradley J
        Tan, Cindy Si En
          Sandis, Alexis
            Araya, Luis Nazario
              Hernández, Jose Luis
                Toye, Philip
                  Hall, Roy A

                    MeSH Terms

                    • Animals
                    • Antibodies, Viral / blood
                    • Costa Rica / epidemiology
                    • Enzyme-Linked Immunosorbent Assay
                    • Horse Diseases / blood
                    • Horse Diseases / diagnosis
                    • Horse Diseases / epidemiology
                    • Horses
                    • West Nile Fever / blood
                    • West Nile Fever / diagnosis
                    • West Nile Fever / epidemiology
                    • West Nile virus / immunology
                    • West Nile virus / isolation & purification

                    Citations

                    This article has been cited 10 times.
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