Detection of Borna disease virus in a pregnant mare and her fetus.
Abstract: A pregnant mare showing pyrexia, reduced appetite, ataxia and paresis was euthanized and examined for the presence of Borna disease virus (BDV). Her brain, showing multiple neuronal degeneration and necrosis with hemorrhage, and the histologically normal brain of the fetus were both positive for BDV RNA. The BDV nucleotide sequences were identical in the mare and fetus in the second open reading frame (ORF). This is the first report of the possible vertical transmission of BDV in a horse.
Publication Date: 2000-03-23 PubMed ID: 10727831DOI: 10.1016/s0378-1135(99)00206-0Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The researchers detected Borna disease virus (BDV) in a pregnant mare and her fetus, suggesting the possibility of this disease being transmitted from mother to offspring in horses.
Background of the Study
- This research focuses on a female horse (mare) that was pregnant and showing symptoms of pyrexia, reduced appetite, uncoordinated movements (ataxia), and partial paralysis (paresis).
- The mare was put down (euthanized) before a detailed examination for Borna disease virus (BDV) was carried out.
Examination Details
- The mare’s brain, which displayed multiple signs of nerve cell degeneration and death (necrosis) along with bleeding (hemorrhage), was examined. The brain of the fetus, which appeared normal under histological examination, was also studied.
- Both the mare and the fetus tested positive for BDV RNA, indicating infection with the virus.
Findings of the Study
- The nucleotide sequences of the BDV in the mare and fetus were identical in a specific region of the virus’s genetic code known as the second open reading frame (ORF). This indicates that the virus found in the fetus could have come directly from the mother.
- These findings provide the first evidence for the possibility of vertical transmission (from mother to offspring) of BDV in horses.
Significance of the Study
- This study provides vital information about the transmissibility of BDV from a pregnant mare to her fetus. Until now, this vertical transmission had not been documented in horses.
- Such a discovery is crucial as it could lead to the development of targeted interventions to prevent the spread of the disease in horse populations.
Cite This Article
APA
Hagiwara K, Kamitani W, Takamura S, Taniyama H, Nakaya T, Tanaka H, Kirisawa R, Iwai H, Ikuta K.
(2000).
Detection of Borna disease virus in a pregnant mare and her fetus.
Vet Microbiol, 72(3-4), 207-216.
https://doi.org/10.1016/s0378-1135(99)00206-0 Publication
Researcher Affiliations
- School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan. k-hagi@rakuno.ac.jp
MeSH Terms
- Animals
- Antibodies, Viral / blood
- Antibodies, Viral / cerebrospinal fluid
- Base Sequence
- Borna Disease / transmission
- Borna disease virus / isolation & purification
- Brain / pathology
- Brain / virology
- DNA Primers / chemistry
- DNA, Viral / chemistry
- Female
- Fetal Diseases / virology
- Horse Diseases / transmission
- Horse Diseases / virology
- Horses
- Immunoblotting / veterinary
- Immunohistochemistry
- In Situ Hybridization / veterinary
- Infectious Disease Transmission, Vertical / veterinary
- Molecular Sequence Data
- Pregnancy
- Pregnancy Complications, Infectious / virology
- RNA, Viral / chemistry
- RNA, Viral / isolation & purification
- Reverse Transcriptase Polymerase Chain Reaction / veterinary
- Sequence Alignment
- Sequence Analysis, DNA
- Sequence Homology, Nucleic Acid
Citations
This article has been cited 10 times.- Sukmak M, Okamoto M, Ando T, Hagiwara K. Genetic stability of the open reading frame 2 (ORF2) of borna disease virus 1 (BoDV-1) distributed in cattle in Hokkaido.. J Vet Med Sci 2021 Oct 2;83(10):1526-1533.
- More S, Bøtner A, Butterworth A, Calistri P, Depner K, Edwards S, Garin-Bastuji B, Good M, Gortázar Schmidt C, Michel V, Miranda MA, Nielsen SS, Raj M, Sihvonen L, Spoolder H, Stegeman JA, Thulke HH, Velarde A, Willeberg P, Winckler C, Baldinelli F, Broglia A, Dhollander S, Beltrán-Beck B, Kohnle L, Bicout D. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Borna disease.. EFSA J 2017 Jul;15(7):e04951.
- Lecollinet S, Pronost S, Coulpier M, Beck C, Gonzalez G, Leblond A, Tritz P. Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?. Viruses 2019 Dec 24;12(1).
- van der Kolk JH. The equine species as Trojan horse for Borna Disease Virus-1?. Vet Q 2018 Dec;38(1):126-128.
- Mazaheri-Tehrani E, Maghsoudi N, Shams J, Soori H, Atashi H, Motamedi F, Bode L, Ludwig H. Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran.. Virol J 2014 Sep 3;11:161.
- Someya A, Fukushima R, Yoshida M, Tanahashi Y, Prapeuk T, Iizuka R, Hirami H, Matsuda A, Takahashi S, Kurita G, Kimura T, Seo M, Funaba M, Nishino Y. A study on Borna disease virus infection in domestic cats in Japan.. J Vet Med Sci 2014 Aug;76(8):1157-60.
- Song JW, Na KS, Tae SH, Kim YK. Borna disease virus antibody and RNA from peripheral blood mononuclear cells of race horses and jockeys in Korea.. Psychiatry Investig 2011 Mar;8(1):58-60.
- Hornig M, Briese T, Lipkin WI. Borna disease virus.. J Neurovirol 2003 Apr;9(2):259-73.
- Vahlenkamp TW, Konrath A, Weber M, Müller H. Persistence of Borna disease virus in naturally infected sheep.. J Virol 2002 Oct;76(19):9735-43.
- Jordan I, Lipkin WI. Borna disease virus.. Rev Med Virol 2001 Jan-Feb;11(1):37-57.
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