Detection of bovine papillomavirus DNA on the normal skin and in the habitual surroundings of horses with and without equine sarcoids.
Abstract: The purpose of the present study was to examine whether bovine papillomavirus (BPV) DNA can be detected on the normal skin and in the habitual surroundings of horses with and without equine sarcoids by means of superficially taken swabs. In affected horses, no significant difference in presence of BPV-DNA could be observed between samples obtained from the equine sarcoid surface, from normal skin close to the tumour and from a normal skin site in direct contact with the tumour. From the group of healthy horses living in contact with affected horses, 44% were BPV-DNA positive. The surroundings of affected and non-affected horses are probably not a major source of BPV-DNA contamination. It can be concluded that BPV-DNA is present on the normal skin of horses affected by equine sarcoid and to a lesser degree, on the normal skin of horses living in contact with affected horses.
Publication Date: 2005-02-26 PubMed ID: 16054896DOI: 10.1016/j.rvsc.2004.12.003Google Scholar: Lookup
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- Journal Article
Summary
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This study investigates whether bovine papillomavirus (BPV) DNA, a cause of horse skin tumors known as equine sarcoids, can be detected on the healthy skin and usual surroundings of horses with and without these tumors using surface-level swabs. The study found that horses affected by equine sarcoids, and to a lesser extent those sharing their living environment, had detectable levels of BPV-DNA on their skin.
Research Aims
- The aim of this study was to identify the presence of bovine papillomavirus (BPV) DNA on the skin and ordinary living environments of horses suffering from equine sarcoids, and those without the condition.
Methods
- The researchers used superficial swabs to sample the healthy skin of horses, both affected by equine sarcoids and those without, as well as swabbing the habitual surroundings of these horses.
Findings
- The researchers found no significant difference in BPV-DNA presence between samples taken from the surface of equine sarcoids, from healthy skin close to the tumor, and from a healthy skin site in direct contact with the tumor in affected horses.
- In the group of healthy horses sharing an environment with affected horses, 44% had detectable levels of BPV-DNA.
- The study found that the living environments of both affected and unaffected horses likely aren’t a significant source of BPV-DNA contamination.
Conclusion
- It was concluded that BPV-DNA is present on the normal skin of horses suffering from equine sarcoids, and to a lesser degree on the normal skin of horses that live in contact with affected horses.
Cite This Article
APA
Bogaert L, Martens A, De Baere C, Gasthuys F.
(2005).
Detection of bovine papillomavirus DNA on the normal skin and in the habitual surroundings of horses with and without equine sarcoids.
Res Vet Sci, 79(3), 253-258.
https://doi.org/10.1016/j.rvsc.2004.12.003 Publication
Researcher Affiliations
- Department of Surgery and Anaesthesiology of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. lies.bogaert@UGent.be
MeSH Terms
- Animals
- Bovine papillomavirus 1 / genetics
- Bovine papillomavirus 1 / isolation & purification
- Cattle
- DNA, Viral / isolation & purification
- Horse Diseases / transmission
- Horse Diseases / virology
- Horses
- Housing, Animal
- Papillomavirus Infections / transmission
- Papillomavirus Infections / veterinary
- Papillomavirus Infections / virology
- Skin / virology
- Skin Neoplasms / veterinary
- Skin Neoplasms / virology
Citations
This article has been cited 12 times.- Hainisch EK, Jindra C, Kirnbauer R, Brandt S. Papillomavirus-like Particles in Equine Medicine. Viruses 2023 Jan 25;15(2).
- Podstawski P, Ropka-Molik K, Semik-Gurgul E, Samiec M, Skrzyszowska M, Podstawski Z, Szmatoła T, Witkowski M, Pawlina-Tyszko K. Tracking the Molecular Scenarios for Tumorigenic Remodeling of Extracellular Matrix Based on Gene Expression Profiling in Equine Skin Neoplasia Models. Int J Mol Sci 2022 Jun 10;23(12).
- Munday JS, Orbell G, Fairley RA, Hardcastle M, Vaatstra B. Evidence from a Series of 104 Equine Sarcoids Suggests That Most Sarcoids in New Zealand Are Caused by Bovine Papillomavirus Type 2, although Both BPV1 and BPV2 DNA Are Detectable in around 10% of Sarcoids. Animals (Basel) 2021 Oct 29;11(11).
- de Alcântara BK, Lunardi M, Agnol AMD, Alfieri AF, Alfieri AA. Detection and Quantification of the E6 Oncogene in Bovine Papillomavirus Types 2 and 13 From Urinary Bladder Lesions of Cattle. Front Vet Sci 2021;8:673189.
- Willemsen A, Bravo IG. Origin and evolution of papillomavirus (onco)genes and genomes. Philos Trans R Soc Lond B Biol Sci 2019 May 27;374(1773):20180303.
- Savini F, Gallina L, Mazza F, Mariella J, Castagnetti C, Scagliarini A. Molecular Detection of Bovine Papillomavirus DNA in the Placenta and Blood of Healthy Mares and Respective Foals. Vet Sci 2019 Feb 6;6(1).
- Martano M, Corteggio A, Restucci B, De Biase ME, Borzacchiello G, Maiolino P. Extracellular matrix remodeling in equine sarcoid: an immunohistochemical and molecular study. BMC Vet Res 2016 Feb 2;12:24.
- Wilford S, Woodward E, Dunkel B. Owners' perception of the efficacy of Newmarket bloodroot ointment in treating equine sarcoids. Can Vet J 2014 Jul;55(7):683-6.
- Lunardi M, de Alcântara BK, Otonel RA, Rodrigues WB, Alfieri AF, Alfieri AA. Bovine papillomavirus type 13 DNA in equine sarcoids. J Clin Microbiol 2013 Jul;51(7):2167-71.
- Hartl B, Hainisch EK, Shafti-Keramat S, Kirnbauer R, Corteggio A, Borzacchiello G, Tober R, Kainzbauer C, Pratscher B, Brandt S. Inoculation of young horses with bovine papillomavirus type 1 virions leads to early infection of PBMCs prior to pseudo-sarcoid formation. J Gen Virol 2011 Oct;92(Pt 10):2437-2445.
- Wobeser BK, Davies JL, Hill JE, Jackson ML, Kidney BA, Mayer MN, Townsend HG, Allen AL. Epidemiology of equine sarcoids in horses in western Canada. Can Vet J 2010 Oct;51(10):1103-8.
- Vychodilova L, Plasil M, Futas J, Kopecka A, Molinkova D, Wijacki T, Jahn P, Knoll A, Horin P. Genetic susceptibility to sarcoid in Arabian horses: associations with MHC class II and compound MHC class I/KLRA genotypes. Vet Res Commun 2025 May 1;49(3):184.
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