Determination of the efficacy of pyrantel pamoate at the therapeutic dose rate against the tapeworm Anoplocephala perfoliata in equids using a modification of the critical test method.
Abstract: A total of 59 equids (54 horses and five Shetland ponies) were treated with pyrantel pamoate once, at the dose rate of approximately 6.6 mg base kg-1, during the period November 1985-January 1988. The drug was administered as a paste formulation (51 equids) intraorally or as a suspension formulation by stomach tube (eight equids). The purpose of treatment was to evaluate the activity of pyrantel pamoate (at the therapeutic dose rate) for removal of the tapeworm, Anoplocephala perfoliata, by a modified (24-h) critical test. The presence or absence of tapeworms was not determined for the equids before treatment. Twenty-three (39%) of the 59 treated equids were found to be infected with A. perfoliata (from one to 180 specimens per infected equid) at necropsy. Removals varied from 67 to 100% (average 88%) for the 18 infected equids treated with the paste formulation. For the five infected equids treated with the suspension, removals were 58-100% (average 75%). The combined average removal of A. perfoliata for both formulations was 87%. Two abnormal (triradiate) specimens of A. perfoliata were recovered; one from each of two different equids.
Publication Date: 1989-04-01 PubMed ID: 2728327DOI: 10.1016/0304-4017(89)90004-6Google Scholar: Lookup
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Summary
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This study evaluates the effectiveness of using pyrantel pamoate, a drug treatment, on horses and ponies to remove Anoplocephala perfoliata, a type of tapeworm. The experiment resulted in an average removal rate of 87%, regardless of the method of drug administration.
Research Methodology
- Alderman’s research involved a total of 59 equids comprising of 54 horses and five Shetland ponies.
- The research was conducted over the span of November 1985 to January 1988.
- The experimental subjects were treated with a therapeutic dose of the drug pyrantel pamoate, calculated at approximately 6.6mg base kg-1. This was administered in one of two ways; either as a paste formulation intraorally (51 equids) or as a suspension formulation by stomach tube (eight equids).
- The purpose of the study was to assess the efficiency of pyrantel pamoate in eliminating the tapeworm, Anoplocephala perfoliata, using a modified 24-hour critical test.
- A significant detail noted is that the presence or absence of tapeworms in the equids was not determined before the commencement of the treatment.
Results and Findings
- In the aftermath of the experiment, a necropsy revealed that 23 (or 39%) of the 59 treated equids were infected with A. perfoliata ranging from one to 180 specimens per equid.
- The rate of removal for the equids treated with the paste formulation varied from 67 to 100%, averaging at 88% for the 18 infected equids.
- For the five infected equids treated with the suspension, the rate of removal ranged from 58 to 100%, with an average of 75%.
- Combining the results from both methods of administration showed an average removal rate of 87% for A. perfoliata.
- Interestingly, two abnormal specimens of A. perfoliata were also recovered during the study, one from each of two different equids.
Conclusions
- This study has been able to demonstrate the effectiveness of using pyrantel pamoate as a treatment to remove A. perfoliata from the equids.
- The findings indicate that regardless of the formula in which the pyrantel pamoate is administered – whether oral paste or stomach tube suspension – the drug is generally effective in removing a significant proportion of tapeworms.
- This information could prove valuable for experts in equine health or for those in professions involving the care or treatment of horses.
Cite This Article
APA
Lyons ET, Drudge JH, Tolliver SC, Swerczek TW, Collins SS.
(1989).
Determination of the efficacy of pyrantel pamoate at the therapeutic dose rate against the tapeworm Anoplocephala perfoliata in equids using a modification of the critical test method.
Vet Parasitol, 31(1), 13-18.
https://doi.org/10.1016/0304-4017(89)90004-6 Publication
Researcher Affiliations
- Department of Veterinary Science, College of Agriculture, University of Kentucky, Gluck Equine Research Center, Lexington 40546-0099.
MeSH Terms
- Administration, Oral
- Animals
- Cestoda / drug effects
- Cestode Infections / drug therapy
- Cestode Infections / veterinary
- Female
- Horse Diseases / drug therapy
- Horses
- Male
- Ointments
- Pyrantel / analogs & derivatives
- Pyrantel Pamoate / administration & dosage
- Pyrantel Pamoate / therapeutic use
- Suspensions
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