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Home / Equine Research Bank / Vet J / Diagnostic value of the neutrophil myeloperoxidase index in ...
Veterinary journal (London, England : 1997)2011; 191(1); 72-78; doi: 10.1016/j.tvjl.2010.12.010

Diagnostic value of the neutrophil myeloperoxidase index in horses with systemic inflammation.

Abstract: The myeloperoxidase index (MPXI) was investigated as a diagnostic indicator of systemic inflammation in a retrospective study using data from 859 hospitalised horses. A reference interval of 8.5-10.4 for the MPXI was established. In horses with systemic inflammatory response syndrome (SIRS), the MPXI was significantly lower than in healthy horses, those with localised inflammation and those with sepsis. The MPXI in horses with sepsis was also significantly lower than in healthy animals and those with localised inflammation. Horses in the SIRS group with leucopenia, white blood cell (WBC) count within the reference interval (WRI) or leucocytosis had significantly lower MPXIs than healthy horses, those with localised inflammation and those with sepsis in the same WBC count subgroups. In horses with sepsis and WBC count WRI, the MPXI was significantly lower than in healthy horses or those with localised inflammation. MPXI is a useful complementary tool to identify horses with systemic inflammation, especially if they have WBC counts WRI.
Copyright © 2010 Elsevier Ltd. All rights reserved.
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Publication Date: 2011-01-22 PubMed ID: 21262582DOI: 10.1016/j.tvjl.2010.12.010Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper focuses on studying the effectiveness of the myeloperoxidase index (MPXI) as a diagnostic marker for systemic inflammation in horses. It identified that horses with systemic inflammation, more so those with normal white blood cell count, presented lower MPXI, setting it as a useful tool in identifying such health issues.

Study Background

  • The research retrospectively analyzed data from 859 hospitalized horses to study the value of the MPXI as a marker for systemic inflammation.
  • The MPXI is a measure derived from white blood cells, particularly neutrophils, and is an indicator of their activation state.
  • The focus of the study was to establish the MPXI’s effectiveness in identifying horses suffering from a systemic inflammatory response syndrome (SIRS) or sepsis, both severe forms of inflammation that affect the whole body.

Findings

  • The researchers established a reference interval of 8.5-10.4 for the MPXI.
  • Horses battling SIRS were found to exhibit significantly lower MPXI than healthy horses, those with localized inflammation, and those with sepsis.
  • Similarly, horses with sepsis also displayed significantly lower MPXI than healthy horses and those with localized inflammation.
  • Upon further dissection of the data into subgroups based on white blood cell (WBC) count, it was inferred that even within each WBC subgroup (leucopenia: low WBC count, WRI: WBC count within the reference interval, or leucocytosis: high WBC count), horses with SIRS had considerably lower MPXI.
  • In septic horses with WBC count within the reference interval, the MPXI was still significantly lower compared to healthy horses or those with local inflammation.

Conclusion and Importance

  • The research concludes that the MPXI can be a valuable supplementing diagnostic tool for identifying systemic inflammation in horses, particularly useful when horses have a WBC count within the normal range.
  • This unique aspect is significant as systemic inflammation could potentially go unnoticed in cases where the horse has a normal WBC count, potentially leading to delayed treatment and poorer health outcomes.
  • Thus, monitoring the MPXI could provide an early warning sign of severe systemic inflammation, leading to timely intervention and treatment.

Cite This Article

APA
Schwarz BC, van den Hoven R, Schwendenwein I. (2011). Diagnostic value of the neutrophil myeloperoxidase index in horses with systemic inflammation. Vet J, 191(1), 72-78. https://doi.org/10.1016/j.tvjl.2010.12.010

Publication

Veterinary journal (London, England : 1997)
ISSN: 1532-2971
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 191
Issue: 1
Pages: 72-78

Researcher Affiliations

Schwarz, Bianca C
  • Equine Hospital, Section Internal Medicine, Department for Small Animals and Horses, Vetmeduni Vienna, Veterinärplatz 1, 1210 Vienna, Austria. bianca.schwarz@vetmeduni.ac.at
van den Hoven, René
    Schwendenwein, Ilse

      MeSH Terms

      • Animals
      • Female
      • Horse Diseases / blood
      • Horse Diseases / diagnosis
      • Horses
      • Leukocyte Count / veterinary
      • Male
      • Neutrophils / metabolism
      • Peroxidase / metabolism
      • Predictive Value of Tests
      • Retrospective Studies
      • Sepsis / diagnosis
      • Sepsis / veterinary
      • Systemic Inflammatory Response Syndrome / diagnosis
      • Systemic Inflammatory Response Syndrome / veterinary

      Citations

      This article has been cited 11 times.
      1. Blangy-Letheule A, Vergnaud A, Dupas T, Rozec B, Lauzier B, Leroux AA. Spontaneous Sepsis in Adult Horses: From Veterinary to Human Medicine Perspectives.. Cells 2023 Mar 30;12(7).
        doi: 10.3390/cells12071052pubmed: 37048125google scholar: lookup
      2. Kim YB, Lee KW. Role of Dietary Methyl Sulfonyl Methane in Poultry.. Animals (Basel) 2023 Jan 19;13(3).
        doi: 10.3390/ani13030351pubmed: 36766239google scholar: lookup
      3. Theuerkauf K, Obach-Schröck C, Staszyk C, Moritz A, Roscher KA. Activated platelets and platelet-leukocyte aggregates in the equine systemic inflammatory response syndrome.. J Vet Diagn Invest 2022 May;34(3):448-457.
        doi: 10.1177/10406387221077969pubmed: 35168432google scholar: lookup
      4. Ehrmann C, Engel J, Moritz A, Roscher K. Assessment of platelet biology in equine patients with systemic inflammatory response syndrome.. J Vet Diagn Invest 2021 Mar;33(2):300-307.
        doi: 10.1177/1040638720983791pubmed: 33353486google scholar: lookup
      5. Taylor S. A review of equine sepsis.. Equine Vet Educ 2015 Feb;27(2):99-109.
        doi: 10.1111/eve.12290pubmed: 32313390google scholar: lookup
      6. Celliers A, Rautenbach Y, Hooijberg E, Christopher M, Goddard A. Neutrophil Myeloperoxidase Index in Dogs With Babesiosis Caused by Babesia rossi.. Front Vet Sci 2020;7:72.
        doi: 10.3389/fvets.2020.00072pubmed: 32133380google scholar: lookup
      7. Roy MF, Kwong GP, Lambert J, Massie S, Lockhart S. Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome.. J Vet Intern Med 2017 Mar;31(2):582-592.
        doi: 10.1111/jvim.14670pubmed: 28207163google scholar: lookup
      8. Leidinger EF, Leidinger J, Figl J, Rumpler B, Schwendenwein I. Application of the ASVCP guidelines for the establishment of haematologic and biochemical reference intervals in Icelandic horses in Austria.. Acta Vet Scand 2015 Jun 14;57(1):30.
        doi: 10.1186/s13028-015-0120-4pubmed: 26070944google scholar: lookup
      9. Hoffman CJ, McKenzie HC 3rd, Furr MO, Desrochers A. Glucocorticoid receptor density and binding affinity in healthy horses and horses with systemic inflammatory response syndrome.. J Vet Intern Med 2015 Mar-Apr;29(2):626-35.
        doi: 10.1111/jvim.12558pubmed: 25818217google scholar: lookup
      10. Hooijberg EH, van den Hoven R, Tichy A, Schwendenwein I. Diagnostic and predictive capability of routine laboratory tests for the diagnosis and staging of equine inflammatory disease.. J Vet Intern Med 2014 Sep-Oct;28(5):1587-93.
        doi: 10.1111/jvim.12404pubmed: 25056342google scholar: lookup
      11. Bohlooli S, Mohammadi S, Amirshahrokhi K, Mirzanejad-Asl H, Yosefi M, Mohammadi-Nei A, Chinifroush MM. Effect of Methylsulfonylmethane Pretreatment on Aceta-minophen Induced Hepatotoxicity in Rats.. Iran J Basic Med Sci 2013 Aug;16(8):896-900.
        pubmed: 24106592
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