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Home / Equine Research Bank / Vet Anaesth Analg / Differences in need for hemodynamic support in horses anesth...
Veterinary anaesthesia and analgesia2006; 33(6); 356-367; doi: 10.1111/j.1467-2995.2005.00279.x

Differences in need for hemodynamic support in horses anesthetized with sevoflurane as compared to isoflurane.

Abstract: To study whether hemodynamic function in horses, particularly mean arterial blood pressure (MAP), is better maintained with sevoflurane than isoflurane, thus requiring less pharmacological support. Methods: Prospective randomized clinical investigation. Animals Thirty-nine racehorses undergoing arthroscopy in lateral recumbency. Methods: Horses were assigned to receive either isoflurane (n = 20) or sevoflurane (n = 19) at 0.9-1.0 minimum alveolar concentration (MAC) for maintenance of anesthesia. Besides routine clinical monitoring, cardiac output (CO) was measured by lithium dilution. Hemodynamic support was prescribed as follows: when MAP decreased to 85 mmHg or heart rate >60 beats minute(-1). Statistical analysis of results, given as mean +/- SD, included a clustered regression approach. Results: Average inhalant anesthetic time [91 +/- 35 (isoflurane group) versus 97 +/- 26 minutes (sevoflurane group)] and dose (in MAC multiples), volume of crystalloid solution infused, and cardiopulmonary parameters including CO were similar in the two groups, except heart rate was 8% higher in isoflurane than sevoflurane horses (p 70 mmHg, isoflurane horses received dobutamine over a significantly longer period (55 +/- 26 versus 28 +/- 21% of total anesthetic time, p 30 microg kg(-1) MAC hour(-1) (p < 0.05). Dobutamine infusion rates were consistently lower in the sevoflurane as compared to the isoflurane group, with differences reaching significance level during the 0-30 minutes (p < 0.01) and 61-90 minutes periods (p < 0.05). Conclusions: Horses under sevoflurane anesthesia may require less pharmacological support in the form of dobutamine than isoflurane-anesthetized horses. This could be due to less suppression of vasomotor tone.
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Publication Date: 2006-11-07 PubMed ID: 17083608DOI: 10.1111/j.1467-2995.2005.00279.xGoogle Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on the comparison between sevoflurane and isoflurane anesthetics in horses, finding that horses anesthetized with sevoflurane required less hemodynamic support through dobutamine than those anesthetized with isoflurane.

Study Design and Methodology

  • The study was designed as a prospective randomized clinical investigation involving 39 racehorses that needed to undergo arthroscopy. These horses were divided into two groups – one group to be anesthetized with sevoflurane (n = 19) and the other with isoflurane (n = 20).
  • The measure of anesthesia, referred to as the minimum alveolar concentration (MAC), for both isoflurane and sevoflurane was maintained at 0.9-1.0. Additionally, the cardiac output of the horses was measured using lithium dilution.
  • To maintain the hemodynamic function of the horses, dobutamine was administered when the mean arterial pressure (MAP) dropped to below 70 mmHg. The administration of dobutamine was stopped when the MAP rose above 85 mmHg or if the heart rate of the horse increased to more than 60 beats per minute.

Results

  • Similarities in anesthetic time, dose, infused crystalloid solution volume, and cardiopulmonary parameters were observed in both groups. The only difference observed was an 8% higher heart rate in horses that were given isoflurane.
  • The isoflurane group required significantly longer periods of dobutamine infusion to maintain MAP above 70 mmHg compared to the sevoflurane group. Also, the isoflurane horses received a 51% higher dose of dobutamine than the sevoflurane horses.
  • 14 out of 20 horses in the isoflurane group were given dobutamine at more than 30 micrograms per kilogram per MAC hour, compared with only 9 out of the 19 horses in the sevoflurane group.
  • The rate of dobutamine infusion was consistently lower in the sevoflurane group than the isoflurane group.

Conclusions

  • The study concluded that horses under sevoflurane anesthesia may require less pharmacological support in the form of dobutamine than isoflurane-anesthetized horses. This could be due to less suppression of vasomotor tone.

Cite This Article

APA
Driessen B, Nann L, Benton R, Boston R. (2006). Differences in need for hemodynamic support in horses anesthetized with sevoflurane as compared to isoflurane. Vet Anaesth Analg, 33(6), 356-367. https://doi.org/10.1111/j.1467-2995.2005.00279.x

Publication

Veterinary anaesthesia and analgesia
ISSN: 1467-2987
NlmUniqueID: 100956422
Country: United States
Language: English
Volume: 33
Issue: 6
Pages: 356-367

Researcher Affiliations

Driessen, Bernd
  • Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, Section of Critical Care/Anesthesia, University of Pennsylvania, PA 19348, USA. driessen@vet.upenn.edu
Nann, Lawrence
    Benton, Robin
      Boston, Raymond

        MeSH Terms

        • Anesthesia, Inhalation / veterinary
        • Anesthetics, Inhalation / administration & dosage
        • Anesthetics, Inhalation / pharmacology
        • Animals
        • Blood Pressure / drug effects
        • Dobutamine / administration & dosage
        • Female
        • Heart Rate / drug effects
        • Horses / physiology
        • Isoflurane / administration & dosage
        • Isoflurane / pharmacology
        • Male
        • Methyl Ethers / administration & dosage
        • Methyl Ethers / pharmacology
        • Prospective Studies
        • Pulmonary Alveoli / drug effects
        • Sevoflurane

        Citations

        This article has been cited 9 times.
        1. Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature. Animals (Basel) 2021 Jun 14;11(6).
          doi: 10.3390/ani11061777pubmed: 34198637google scholar: lookup
        2. Cerullo M, Driessen B, Douglas H, Hopster K. Changes in Arterial Blood Pressure and Oxygen Tension as a Result of Hoisting in Isoflurane Anesthetized Healthy Adult Horses. Front Vet Sci 2020;7:601326.
          doi: 10.3389/fvets.2020.601326pubmed: 33324704google scholar: lookup
        3. Tokushige H, Okano A, Arima D, Ito H, Kambayashi Y, Minamijima Y, Ohta M. Clinical effects of constant rate infusions of medetomidine-propofol combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery. Acta Vet Scand 2018 Nov 5;60(1):71.
          doi: 10.1186/s13028-018-0426-0pubmed: 30396363google scholar: lookup
        4. Tokushige H, Kushiro A, Okano A, Maeda T, Ito H, Wakuno A, Nagata SI, Ohta M. Clinical evaluation of constant rate infusion of alfaxalone-medetomidine combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery. Acta Vet Scand 2018 Sep 4;60(1):50.
          doi: 10.1186/s13028-018-0406-4pubmed: 30180855google scholar: lookup
        5. Wakuno A, Maeda T, Kodaira K, Kikuchi T, Ohta M. Anesthetic management with sevoflurane combined with alfaxalone-medetomidine constant rate infusion in a Thoroughbred racehorse undergoing a long-time orthopedic surgery. J Equine Sci 2017;28(3):111-115.
          doi: 10.1294/jes.28.111pubmed: 28955163google scholar: lookup
        6. Gupta M, Shri I, Sakia P, Govil D. Comparison of equi-minimum alveolar concentration of sevoflurane and isoflurane on bispectral index values during both wash in and wash out phases: A prospective randomised study. Indian J Anaesth 2015 Feb;59(2):79-84.
          doi: 10.4103/0019-5049.151363pubmed: 25788739google scholar: lookup
        7. Negargar S, Peirovifar A, Mahmoodpoor A, Parish M, Golzari SE, Molseqi H, Negargar S. Hemodynamic parameters of low-flow isoflurane and low-flow sevoflurane anesthesia during controlled ventilation with laryngeal mask airway. Anesth Pain Med 2014 Dec;4(5):e20326.
          doi: 10.5812/aapm.20326pubmed: 25729676google scholar: lookup
        8. Ohta M, Kurimoto S, Ishikawa Y, Tokushige H, Mae N, Nagata S, Mamada M. Cardiovascular effects of dobutamine and phenylephrine infusion in sevoflurane-anesthetized Thoroughbred horses. J Vet Med Sci 2013 Nov;75(11):1443-8.
          doi: 10.1292/jvms.13-0104pubmed: 23832627google scholar: lookup
        9. Regueiro-Purriños M, Fernández-Vázquez F, de Prado AP, Altónaga JR, Cuellas-Ramón C, Ajenjo-Silverio JM, Orden A, Gonzalo-Orden JM. Ventricular arrhythmias and mortality associated with isoflurane and sevoflurane in a porcine model of myocardial infarction. J Am Assoc Lab Anim Sci 2011 Jan;50(1):73-8.
          pubmed: 21333167
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