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Home / Equine Research Bank / J Vet Intern Med / Differences in ultrasound-derived arterial wall stiffness pa...
Journal of veterinary internal medicine2020; 34(2); 893-901; doi: 10.1111/jvim.15705

Differences in ultrasound-derived arterial wall stiffness parameters and noninvasive blood pressure between Friesian horses and Warmblood horses.

Abstract: Aortic rupture is more common in Friesians compared to Warmbloods, which might be related to differences in arterial wall composition and, as such, arterial wall stiffness (AWS). Currently, nothing is known about differences in AWS between these breeds. Objective: Comparison of AWS parameters and noninvasive blood pressure between Friesians and Warmbloods. Methods: One hundred one healthy Friesians and 101 age-matched healthy Warmbloods. Methods: Two-dimensional and pulsed-wave Doppler ultrasound examination was performed of the aorta, common carotid artery, and external iliac artery to define local and regional AWS parameters. Regional aortic AWS was estimated using aortic-to-external iliac artery pulse wave velocity (PWVa-e ) and carotid-to-external iliac artery pulse wave velocity (PWVc-e ). Noninvasive blood pressure and heart rate were recorded simultaneously. Results: Systolic, diastolic, and mean arterial blood pressure and pulse pressure were significantly higher in Friesians compared to Warmbloods. No significant difference in heart rate was found. Most local AWS parameters (diameter change, compliance coefficient, distensibility coefficient) were significantly lower in Friesians compared to Warmbloods, indicating a stiffer aorta in Friesians. This difference could be confirmed by the regional stiffness parameters. A higher PWVa-e and PWVc-e was found in Friesians. For the cranial and caudal common carotid artery and external iliac artery, most local AWS parameters were not significantly different. Conclusions: Results indicate that aortic AWS differs between Friesian and Warmblood horses. Friesians seem to have a stiffer aorta, which might be related to the higher incidence of aortic rupture in Friesians.
© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2020-02-07 PubMed ID: 32032455PubMed Central: PMC7096643DOI: 10.1111/jvim.15705Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study compares arterial wall stiffness and blood pressure in two different breeds of horses. The research might help explain why Friesian horses are more prone to aortic rupture than Warmblood horses.

Introduction and Objective

  • This study was initiated given that aortic rupture, a serious health condition, happens more often in Friesian horses than in Warmblood horses. The researchers suspected this disparity could be due to differing compositions of the arterial wall in these breeds, which leads to distinct Arterial Wall Stiffness (AWS).
  • The main objective of the study was to compare differences in arterial wall stiffness parameters and blood pressure readings between Friesian and Warmblood horses.

Methodology

  • A sample of 101 healthy Friesian horses and 101 healthy Warmblood horses that were matched by age were used for this study.
  • The researchers used 2D and pulsed-wave Doppler ultrasound techniques to examine the aorta, the common carotid artery, and the external iliac artery of each horse. This helped define both local and regional AWS parameters.
  • Noninvasive measurements of heart rate and blood pressure were also taken simultaneously.

Results

  • Results indicated that systolic, diastolic, and mean arterial blood pressure, as well as pulse pressure, were significantly higher in Friesian horses compared to Warmblood horses. The heart rate, on the other hand, did not significantly differ between the two breeds.
  • Most local AWS parameters, like diameter change, compliance coefficient, and distensibility coefficient, were notably lower in Friesians, implying that Friesians had stiffer aortas. This hypothesis was further supported by the parameters of regional stiffness.
  • For the cranial and caudal common carotid artery and external iliac artery, most local AWS parameters did not show a significant difference.

Conclusions

  • The study concluded that the arterial wall stiffness does indeed vary between Friesian and Warmblood horses. It appears that Friesians have a stiffer aorta, which could be linked to the higher rate of aortic ruptures seen in this breed.

Cite This Article

APA
Vera L, De Clercq D, Van Steenkiste G, Decloedt A, Chiers K, van Loon G. (2020). Differences in ultrasound-derived arterial wall stiffness parameters and noninvasive blood pressure between Friesian horses and Warmblood horses. J Vet Intern Med, 34(2), 893-901. https://doi.org/10.1111/jvim.15705

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 34
Issue: 2
Pages: 893-901

Researcher Affiliations

Vera, Lisse
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Equine cardioteam, Ghent University, Merelbeke, Belgium.
De Clercq, Dominique
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Equine cardioteam, Ghent University, Merelbeke, Belgium.
Van Steenkiste, Glenn
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Equine cardioteam, Ghent University, Merelbeke, Belgium.
Decloedt, Annelies
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Equine cardioteam, Ghent University, Merelbeke, Belgium.
Chiers, Koen
  • Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
van Loon, Gunther
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Equine cardioteam, Ghent University, Merelbeke, Belgium.

MeSH Terms

  • Animals
  • Aorta / physiology
  • Aortic Rupture / physiopathology
  • Aortic Rupture / veterinary
  • Blood Pressure
  • Carotid Artery, Common / physiology
  • Female
  • Horse Diseases / diagnostic imaging
  • Horse Diseases / physiopathology
  • Horses
  • Male
  • Pedigree
  • Pulsatile Flow
  • Pulse Wave Analysis / veterinary
  • Ultrasonography / veterinary
  • Vascular Stiffness

Grant Funding

  • 1134917N / Fonds Wetenschappelijk Onderzoek
  • 1S56217N / Fonds Wetenschappelijk Onderzoek

Conflict of Interest Statement

Authors declare no conflict of interest.

References

This article includes 41 references
  1. Ploeg M, Saey V, van Loon G, Delesalle C. Thoracic aortic rupture in horses.. Equine Vet J 2017;49:269‐274.
    pubmed: 27783422
  2. Sleeper MM, Durando MM, Miller M, Habecker PL, Reef VB. Aortic root disease in four horses.. J Am Vet Med Assoc 2001;219:491‐496.
    pubmed: 11518177
  3. Marr CM, Reef VB, Brazil TJ. Aorto‐cardiac fistulas in seven horses.. Vet Radiol Ultrasound 1998;39:22‐31.
    pubmed: 9491514
  4. Shirai W, Momotani E, Sato T, Kashima T, Saito T, Itoi Y. Dissecting aortic aneurysm in a horse.. J Comp Pathol 1999;120:307‐311.
    pubmed: 10213675
  5. Ploeg M, Saey V, de Bruijn CM. Aortic rupture and aorto‐pulmonary fistulation in the Friesian horse: characterisation of the clinical and gross post mortem findings in 24 cases.. Equine Vet J 2013;45:101‐106.
    pubmed: 22607232
  6. van der Linde‐Sipman JS, Kroneman J, Meulenaar H. Necrosis and rupture of the aorta and pulmonary trunk in four horses.. Vet Pathol 1985;22:51‐53.
    pubmed: 3976133
  7. Ploeg M, Saey V, Delesalle C. Thoracic aortic rupture and aortopulmonary fistulation in the Friesian horse: histomorphologic characterization.. Vet Pathol 2015;52:152‐159.
    pubmed: 24741028
  8. Dobrin PB, Baker WH, Gley WC. Elastolytic and collagenolytic studies of arteries. Implications for the mechanical properties of aneurysms.. Arch Surg 1984;119:405‐409.
    pubmed: 6322726
  9. Berillis P. The role of collagen in the Aorta's structure.. Open Circ Vasc J 2013;6:1‐8.
  10. Ploeg M, Grone A, van de Lest CHA. Differences in extracellular matrix proteins between Friesian horses with aortic rupture, unaffected Friesians and Warmblood horses.. Equine Vet J 2017;49:609‐613.
    pubmed: 27859600
  11. Saey V, Tang J, Ducatelle R. Elevated urinary excretion of free pyridinoline in Friesian horses suggests a breed‐specific increase in collagen degradation.. BMC Vet Res 2018;14:139.
    pmc: PMC5921786pubmed: 29699546
  12. Saey V, Ploeg M, Delesalle C. Morphometric properties of the thoracic aorta of Warmblood and Friesian horses with and without aortic rupture.. J Comp Pathol 2016;154:225‐230.
    pubmed: 26987511
  13. Yuan SM, Jing H. Cystic medial necrosis: pathological findings and clinical implications.. Rev Bras Cir Cardiovasc 2011;26:107‐115.
    pubmed: 21881719
  14. Schlatmann TJ, Becker AE. Histologic changes in the normal aging aorta: implications for dissecting aortic aneurysm.. Am J Cardiol 1977;39:13‐20.
    pubmed: 831420
  15. Vine N, Powell JT. Metalloproteinases in degenerative aortic disease.. Clin Sci (Lond) 1991;81:233‐239.
    pubmed: 1653668
  16. Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London G'M. Impact of aortic stiffness on survival in end‐stage renal disease.. Circulation 1999;99:2434‐2439.
    pubmed: 10318666
  17. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG. Aortic pulse‐wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?. Circulation 2002;106:2085‐2090.
    pubmed: 12379578
  18. Laurent S, Boutouyrie P, Asmar R. Aortic stiffness is an independent predictor of all‐cause and cardiovascular mortality in hypertensive patients.. Hypertension 2001;37:1236‐1241.
    pubmed: 11358934
  19. Inoue N, Maeda R, Kawakami H. Aortic pulse wave velocity predicts cardiovascular mortality in middle‐aged and elderly Japanese men.. Circ J 2009;73:549‐553.
    pubmed: 19179770
  20. Safar ME, Henry O, Meaume S. Aortic pulse wave velocity: an independent marker of cardiovascular risk.. Am J Geriatr Cardiol 2002;11:295‐298.
    pubmed: 12214167
  21. Messas E, Pernot M, Couade M. Arterial wall elasticity: state of the art and future prospects.. Diagn Interv Imaging 2013;94:561‐569.
    pubmed: 23619291
  22. Davies JI, Struthers AD. Pulse wave analysis and pulse wave velocity: a critical review of their strengths and weaknesses.. J Hypertens 2003;21:463‐472.
    pubmed: 12640232
  23. Van Bortel LM, Laurent S, Boutouyrie P. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid‐femoral pulse wave velocity.. J Hypertens 2012;30:445‐448.
    pubmed: 22278144
  24. Hoeks APG, Brands PJ, Willigers JM, Reneman RS. Non‐invasive measurement of mechanical properties of arteries in health and disease.. P I Mech Eng H 1999;213:195‐202.
    pubmed: 10490292
  25. Laurent S, Cockcroft J, Van Bortel L. Expert consensus document on arterial stiffness: methodological issues and clinical applications.. Eur Heart J 2006;27:2588‐2605.
    pubmed: 17000623
  26. Jiang B, Liu B, McNeill KL. Measurement of pulse wave velocity using pulse wave Doppler ultrasound: comparison with arterial tonometry.. Ultrasound Med Biol 2008;34:509‐512.
    pubmed: 18031922
  27. Calabia J, Torguet P, Garcia M. Doppler ultrasound in the measurement of pulse wave velocity: agreement with the Complior method.. Cardiovasc Ultrasound 2011;9:13.
    pmc: PMC3098145pubmed: 21496271
  28. Carroll CL, Huntington PJ. Body condition scoring and weight estimation of horses.. Equine Vet J 1988;20:41‐45.
    pubmed: 3366105
  29. Izzo JL Jr. Brachial vs. central systolic pressure and pulse wave transmission indicators: a critical analysis.. Am J Hypertens 2014;27:1433‐1442.
    pubmed: 25233859
  30. O'Rourke MF, Staessen JA, Vlachopoulos C. Clinical applications of arterial stiffness; definitions and reference values.. Am J Hypertens 2002;15:426‐444.
    pubmed: 12022246
  31. Heliczer N, Lorello O, Casoni D, Navas de Solis C. Accuracy and precision of noninvasive blood pressure in normo‐, hyper‐, and hypotensive standing and anesthetized adult horses.. J Vet Intern Med 2016;30:866‐872.
    pmc: PMC4913577pubmed: 27059803
  32. Boegli J, Schwarzwald CC, Mitchell KJ. Diagnostic value of noninvasive pulse pressure measurements in Warmblood horses with aortic regurgitation.. J Vet Intern Med 2019;33:1446‐1455.
    pmc: PMC6524107pubmed: 30938891
  33. Ven S, Decloedt A, Van der Vekens N. Assessing aortic regurgitation severity from 2D, M‐mode and pulsed wave Doppler echocardiographic measurements in horses.. Vet J 2016;210:34‐38.
    pubmed: 26900009
  34. Vera L, De Clercq D, Paulussen E. Aortic, common carotid and external iliac artery arterial wall stiffness parameters in horses: Inter‐day and inter‐observer and intra‐observer measurement variability.. Equine Vet J 2019; in press.
    pubmed: 31648382
  35. Lyle AN, Raaz U. Killing me Unsoftly causes and mechanisms of arterial stiffness.. Arterioscl Throm Vas 2017;37:E1‐E11.
    pmc: PMC5308873pubmed: 28122777
  36. Tan I, Butlin M, Liu YY, Ng K, Avolio AP. Heart rate dependence of aortic pulse wave velocity at different arterial pressures in rats.. Hypertension 2012;60:528‐533.
    pubmed: 22585952
  37. von Maltzahn WW, Besdo D, Wiemer W. Elastic properties of arteries: a nonlinear two‐layer cylindrical model.. J Biomech 1981;14:389‐397.
    pubmed: 7263731
  38. Hatz LA, Hartnack S, Kummerle J. A study of measurement of noninvasive blood pressure with the oscillometric device, sentinel, in isoflurane‐anaesthetized horses.. Vet Anaesth Analg 2015;42:369‐376.
    pubmed: 25082169
  39. Taylor PM. Techniques and clinical application of arterial blood pressure measurement in the horse.. Equine Vet J 1981;13:271‐275.
    pubmed: 7318810
  40. Oliver JJ, Webb DJ. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events.. Arterioscler Thromb Vasc Biol 2003;23:554‐566.
    pubmed: 12615661
  41. Painter PR. The velocity of the arterial pulse wave: a viscous‐fluid shock wave in an elastic tube.. Theor Biol Med Model 2008;5:15.
    pmc: PMC2527553pubmed: 18664288

Citations

This article has been cited 3 times.
  1. Dufourni A, Buschmann E, Vernemmen I, Van Steenkiste G, van Loon G, Decloedt A. Effect of physiological and pharmacological stress on heart rate, blood pressure, and echocardiographic measurements in healthy Warmblood horses. J Vet Intern Med 2024 Jan-Feb;38(1):398-410.
    doi: 10.1111/jvim.16967pubmed: 38174810google scholar: lookup
  2. Guest B, Arroyo L, Runciman J. A structural approach to 3D-printing arterial phantoms with physiologically comparable mechanical characteristics: Preliminary observations. Proc Inst Mech Eng H 2022 Sep;236(9):1388-1402.
    doi: 10.1177/09544119221114207pubmed: 35913071google scholar: lookup
  3. Vernemmen I, Vera L, Van Steenkiste G, van Loon G, Decloedt A. Reference values for 2-dimensional and M-mode echocardiography in Friesian and Warmblood horses. J Vet Intern Med 2020 Nov;34(6):2701-2709.
    doi: 10.1111/jvim.15938pubmed: 33098342google scholar: lookup
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