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Acta veterinaria Scandinavica2019; 61(1); 28; doi: 10.1186/s13028-019-0464-2

Disposition and effect of intra-articularly administered dexamethasone on lipopolysaccharide induced equine synovitis.

Abstract: Dexamethasone is used for the intra-articular route of administration in management of aseptic arthritis in horses. Despite its widespread use there is very little quantitative data of the disposition and response to dexamethasone. The aim of this study was to investigate and describe the synovial fluid and plasma dexamethasone concentration over time and to explore the relation between synovial fluid concentration and response using clinical endpoints as response biomarkers after IA injection of dexamethasone disodium salt solution in an equine model of synovitis. Results: Inflammation was induced in the radiocarpal joint of six horses by injection of 2 ng lipopolysaccharide (LPS). Two hours later either saline or dexamethasone was injected in the same joint in a two treatment cross over design. Each horse was treated once with one of the six doses dexamethasone used (0.01, 0.03, 0.1, 0.3, 1 or 3 mg) and once with saline. Dexamethasone was quantified by means of UHPLC-MS/MS. Dexamethasone disposition was characterised by means of a non-linear mixed effects model. Lameness was evaluated both objectively with an inertial sensor based system and subjectively scored using a numerical scale (0-5). Joint circumference, skin temperature over the joint and rectal temperature were also recorded. The LPS-challenge induced lameness in all horses with high inter-individual variability. Dexamethasone significantly decreased lameness compared with saline. Other variables were not statistically significant different between treatments. Objective lameness scoring was the most sensitive method used in this study to evaluate the lameness response. A pharmacokinetic/pharmacodynamic model was successfully fitted to experimental dexamethasone and lameness data. The model allowed characterization of the dexamethasone synovial fluid concentration-time course, the systemic exposure to dexamethasone after intra-articular administration and the concentration-response relation in an experimental model of synovitis. Conclusions: The quantitative data improve the understanding of the pharmacology of dexamethasone and might serve as input for future experiments and possibly contribute to maintain integrity of equine sports.
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Publication Date: 2019-06-20 PubMed ID: 31221173PubMed Central: PMC6585085DOI: 10.1186/s13028-019-0464-2Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research aimed to understand the effects of intra-articular dexamethasone on synovitis (joint inflammation) in horses, identifying its concentration over time in synovial fluid and plasma. By studying this along with physiological changes, the research hopes to refine the clinical application of dexamethasone in equine medicine.

Objective and Methodology

  • The study was conducted to gather quantitative data about the administration of dexamethasone, a drug used to manage aseptic arthritis in horses, and its disposition and response within the body.
  • An equine model of synovitis was prepared, where inflammation was induced in the radiocarpal joint of six horses using a 2 ng lipopolysaccharide (LPS) injection.
  • Two hours post the LPS injection, either saline or one of six different doses of dexamethasone was administered in the inflamed joint.
  • Dexamethasone concentration in the synovial fluid and plasma was monitored over time.

Measurements and Results

  • Lameness, a clinical feature of synovitis, was measured both objectively via an inertial sensor-based system and subjectively using a numerical scale.
  • Other parameters such as joint circumference, skin temperature over the joint, and rectal temperature were also recorded to monitor the physiological changes.
  • The LPS-induced synovitis caused lameness in all horses with a significant degree of variability amongst individual horses.
  • Dexamethasone demonstrated a significant reduction in lameness compared to saline, affirming its anti-inflammatory properties.
  • However, other recorded variables didn’t show a statistically significant difference between the dexamethasone and saline treatments.

Outcome and Implication

  • The data generated was evaluated with a pharmacokinetic/pharmacodynamic model, enabling the researchers to characterize the behavior of dexamethasone in the synovial fluid over time, the systemic exposure to it following intra-articular administration, and the association between its concentration and response in synovitis.
  • This research provides valuable quantitative data that enhance our understanding of dexamethasone’s pharmacology.
  • The findings may benefit future experiments on this drug’s use and contribute towards maintaining the integrity of equine sports by improving equine arthritis management.

Cite This Article

APA
Ekstrand C, Bondesson U, Giving E, Hedeland M, Ingvast-Larsson C, Jacobsen S, Löfgren M, Moen L, Rhodin M, Saetra T, Ranheim B. (2019). Disposition and effect of intra-articularly administered dexamethasone on lipopolysaccharide induced equine synovitis. Acta Vet Scand, 61(1), 28. https://doi.org/10.1186/s13028-019-0464-2

Publication

Acta veterinaria Scandinavica
ISSN: 1751-0147
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 61
Issue: 1
Pages: 28
PII: 28

Researcher Affiliations

Ekstrand, Carl
  • Department of Biomedical Sciences and Veterinary Public Health, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Box 7058, 750 07, Uppsala, Sweden. carl.ekstrand@slu.se.
Bondesson, Ulf
  • Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute (SVA), 751 89, Uppsala, Sweden.
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Box 574, 751 23, Uppsala, Sweden.
Giving, Ellen
  • Romerike Hesteklinikk, Riisveien 75, 2007, Kjeller, Norway.
Hedeland, Mikael
  • Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute (SVA), 751 89, Uppsala, Sweden.
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Box 574, 751 23, Uppsala, Sweden.
Ingvast-Larsson, Carina
  • Department of Biomedical Sciences and Veterinary Public Health, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Box 7058, 750 07, Uppsala, Sweden.
Jacobsen, Stine
  • Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 16, 1870, Copenhagen, Frederiksberg C, Denmark.
Löfgren, Maria
  • Department of Biomedical Sciences and Veterinary Public Health, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Box 7058, 750 07, Uppsala, Sweden.
Moen, Lars
  • Romerike Hesteklinikk, Riisveien 75, 2007, Kjeller, Norway.
Rhodin, Marie
  • Department of Anatomy, Physiology and Biochemistry, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Box 7011, 750 07, Uppsala, Sweden.
Saetra, Tonje
  • Rikstotoklinikken Bjerke AS., Postboks 194, 0510, Oslo, Norway.
Ranheim, Birgit
  • Production Animal Clinical Science, Faculty for Veterinary Medicine, The Norwegian University of Life Sciences, Box 369 sentrum, 0102, Oslo, Norway.

MeSH Terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / pharmacokinetics
  • Dexamethasone / administration & dosage
  • Dexamethasone / pharmacokinetics
  • Horse Diseases / chemically induced
  • Horse Diseases / drug therapy
  • Horses
  • Injections, Intra-Articular / veterinary
  • Lipopolysaccharides
  • Synovitis / chemically induced
  • Synovitis / drug therapy
  • Synovitis / veterinary

Conflict of Interest Statement

The authors declare that they have no competing interests.

References

This article includes 56 references
  1. Reed SR, Jackson BF, Mc Ilwraith CW, Wright IM, Pilsworth R, Knapp S, Wood JL, Price JS, Verheyen KL. Descriptive epidemiology of joint injuries in Thoroughbred racehorses in training.. Equine Vet J 2012 Jan;44(1):13-9.
    doi: 10.1111/j.2042-3306.2010.00352.xpubmed: 21496103google scholar: lookup
  2. Neundorf RH, Lowerison MB, Cruz AM, Thomason JJ, McEwen BJ, Hurtig MB. Determination of the prevalence and severity of metacarpophalangeal joint osteoarthritis in Thoroughbred racehorses via quantitative macroscopic evaluation.. Am J Vet Res 2010 Nov;71(11):1284-93.
    doi: 10.2460/ajvr.71.11.1284pubmed: 21034319google scholar: lookup
  3. Labens R, Mellor DJ, Voûte LC. Retrospective study of the effect of intra-articular treatment of osteoarthritis of the distal tarsal joints in 51 horses.. Vet Rec 2007 Nov 3;161(18):611-6.
    doi: 10.1136/vr.161.18.611pubmed: 17982139google scholar: lookup
  4. Kay AT, Bolt DM, Ishihara A, Rajala-Schultz PJ, Bertone AL. Anti-inflammatory and analgesic effects of intra-articular injection of triamcinolone acetonide, mepivacaine hydrochloride, or both on lipopolysaccharide-induced lameness in horses.. Am J Vet Res 2008 Dec;69(12):1646-54.
    doi: 10.2460/ajvr.69.12.1646pubmed: 19046013google scholar: lookup
  5. Salles-Gomes TL, Canola JC, Almeida PE, Canola PA, Souza AH. The effects of intra-articular and intravenous dexamethasone tereoxiacetate administration in horses with intercarpal arthritis induced by injection of Escherichia coli lipopolysaccharide.. Ars Vet 2003;19:241–245.
  6. de Grauw JC, Visser-Meijer MC, Lashley F, Meeus P, van Weeren PR. Intra-articular treatment with triamcinolone compared with triamcinolone with hyaluronate: A randomised open-label multicentre clinical trial in 80 lame horses.. Equine Vet J 2016 Mar;48(2):152-8.
    doi: 10.1111/evj.12383pubmed: 25377505google scholar: lookup
  7. Van Pelt RW, Tillotson PJ, Gertsen KE. Intra-articular injection of betamethasone in arthritis in horses.. J Am Vet Med Assoc 1970 Jun 1;156(11):1589-99.
    pubmed: 5462993
  8. Soma LR, Uboh CE, Liu Y, Li X, Robinson MA, Boston RC, Colahan PT. Pharmacokinetics of dexamethasone following intra-articular, intravenous, intramuscular, and oral administration in horses and its effects on endogenous hydrocortisone.. J Vet Pharmacol Ther 2013 Apr;36(2):181-91.
    doi: 10.1111/j.1365-2885.2012.01412.xpubmed: 22632064google scholar: lookup
  9. Soma LR, Uboh CE, Luo Y, Guan F, Moate PJ, Boston RC. Pharmacokinetics of methylprednisolone acetate after intra-articular administration and its effect on endogenous hydrocortisone and cortisone secretion in horses.. Am J Vet Res 2006 Apr;67(4):654-62.
    doi: 10.2460/ajvr.67.4.654pubmed: 16579759google scholar: lookup
  10. Soma LR, Uboh CE, You Y, Guan F, Boston RC. Pharmacokinetics of intra-articular, intravenous, and intramuscular administration of triamcinolone acetonide and its effect on endogenous plasma hydrocortisone and cortisone concentrations in horses.. Am J Vet Res 2011 Sep;72(9):1234-42.
    doi: 10.2460/ajvr.72.9.1234pubmed: 21879982google scholar: lookup
  11. Menendez MI, Phelps MA, Bertone AL. Pharmacokinetics of intra-articular betamethasone sodium phosphate and betamethasone acetate and endogenous hydrocortisone suppression in exercising horses.. J Vet Pharmacol Ther 2016 Feb;39(1):22-6.
    doi: 10.1111/jvp.12229pubmed: 25847081google scholar: lookup
  12. Menéndez MI, Phelps MA, Hothem EA, Bertone AL. Pharmacokinetics of methylprednisolone acetate after intra-articular administration and subsequent suppression of endogenous hydrocortisone secretion in exercising horses.. Am J Vet Res 2012 Sep;73(9):1453-61.
    doi: 10.2460/ajvr.73.9.1453pubmed: 22924728google scholar: lookup
  13. Lillich JD, Bertone AL, Schmall LM, Ruggles AJ, Sams RA. Plasma, urine, and synovial fluid disposition of methylprednisolone acetate and isoflupredone acetate after intra-articular administration in horses.. Am J Vet Res 1996 Feb;57(2):187-92.
    pubmed: 8633806
  14. Knych HK, Harrison LM, Casbeer HC, McKemie DS. Disposition of methylprednisolone acetate in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses.. J Vet Pharmacol Ther 2014 Apr;37(2):125-32.
    doi: 10.1111/jvp.12070pubmed: 23876165google scholar: lookup
  15. Knych HK, Vidal MA, Casbeer HC, McKemie DS. Pharmacokinetics of triamcinolone acetonide following intramuscular and intra-articular administration to exercised Thoroughbred horses.. Equine Vet J 2013 Nov;45(6):715-20.
    doi: 10.1111/evj.12059pubmed: 23574452google scholar: lookup
  16. Autefage A, Alvinerie M, Toutain PL. Synovial fluid and plasma kinetics of methylprednisolone and methylprednisolone acetate in horses following intra-articular administration of methylprednisolone acetate.. Equine Vet J 1986 May;18(3):193-8.
    doi: 10.1111/j.2042-3306.1986.tb03594.xpubmed: 3732238google scholar: lookup
  17. Chen CL, Sailor JA, Collier J, Wiegand J. Synovial and serum levels of triamcinolone following intra-articular administration of triamcinolone acetonide in the horse.. J Vet Pharmacol Ther 1992 Sep;15(3):240-6.
    doi: 10.1111/j.1365-2885.1992.tb01012.xpubmed: 1433486google scholar: lookup
  18. Wong JK, Wan TS. Doping control analyses in horseracing: a clinician's guide.. Vet J 2014 Apr;200(1):8-16.
    doi: 10.1016/j.tvjl.2014.01.006pubmed: 24485918google scholar: lookup
  19. Toutain PL, Lassourd V. Pharmacokinetic/pharmacodynamic approach to assess irrelevant plasma or urine drug concentrations in postcompetition samples for drug control in the horse.. Equine Vet J 2002 May;34(3):242-9.
    doi: 10.2746/042516402776185985pubmed: 12108741google scholar: lookup
  20. Keegan KG, Kramer J, Yonezawa Y, Maki H, Pai PF, Dent EV, Kellerman TE, Wilson DA, Reed SK. Assessment of repeatability of a wireless, inertial sensor-based lameness evaluation system for horses.. Am J Vet Res 2011 Sep;72(9):1156-63.
    doi: 10.2460/ajvr.72.9.1156pubmed: 21879972google scholar: lookup
  21. Ekstrand C, Ingvast-Larsson C, Olsén L, Hedeland M, Bondesson U, Gabrielsson J. A quantitative approach to analysing cortisol response in the horse.. J Vet Pharmacol Ther 2016 Jun;39(3):255-63.
    doi: 10.1111/jvp.12276pubmed: 26542753google scholar: lookup
  22. Ekstrand C, Bondesson U, Gabrielsson J, Hedeland M, Kallings P, Olsén L, Ingvast-Larsson C. Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate.. J Vet Pharmacol Ther 2015 Jun;38(3):235-42.
    doi: 10.1111/jvp.12175pubmed: 25366540google scholar: lookup
  23. U.S Food and Drug Administration. guidance for industry population pharmacokinetics. https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM072137.pdf. Accessed 04 Mar 2019.
  24. Karlsson MO, Savic RM. Diagnosing model diagnostics.. Clin Pharmacol Ther 2007 Jul;82(1):17-20.
    doi: 10.1038/sj.clpt.6100241pubmed: 17571070google scholar: lookup
  25. Zhang L, Beal SL, Sheiner LB. Simultaneous vs. sequential analysis for population PK/PD data I: best-case performance.. J Pharmacokinet Pharmacodyn 2003 Dec;30(6):387-404.
    doi: 10.1023/B:JOPA.0000012998.04442.1fpubmed: 15000421google scholar: lookup
  26. Aarons L. Sparse data analysis.. Eur J Drug Metab Pharmacokinet 1993 Jan-Mar;18(1):97-100.
    doi: 10.1007/BF03220012pubmed: 8335044google scholar: lookup
  27. Aarons L, Graham G. Methodological approaches to the population analysis of toxicity data.. Toxicol Lett 2001 Mar 31;120(1-3):405-10.
    doi: 10.1016/S0378-4274(01)00272-7pubmed: 11323200google scholar: lookup
  28. Hing JP, Woolfrey SG, Greenslade D, Wright PM. Is mixed effects modeling or naïve pooled data analysis preferred for the interpretation of single sample per subject toxicokinetic data?. J Pharmacokinet Pharmacodyn 2001 Apr;28(2):193-210.
    doi: 10.1023/A:1011507100493pubmed: 11381570google scholar: lookup
  29. Grady JA, Davis EG, Kukanich B, Sherck AB. Pharmacokinetics and pharmacodynamics of dexamethasone after oral administration in apparently healthy horses.. Am J Vet Res 2010 Jul;71(7):831-9.
    doi: 10.2460/ajvr.71.7.831pubmed: 20594087google scholar: lookup
  30. Soma LR, Uboh CE, Luo Y, Guan F, Moate PJ, Boston RC. Pharmacokinetics of dexamethasone with pharmacokinetic/pharmacodynamic model of the effect of dexamethasone on endogenous hydrocortisone and cortisone in the horse.. J Vet Pharmacol Ther 2005 Feb;28(1):71-80.
    doi: 10.1111/j.1365-2885.2004.00632.xpubmed: 15720518google scholar: lookup
  31. Ekstrand C, Ingvast-Larsson C, Bondesson U, Hedeland M, Ranheim B. Disposition of dexamethasone in the inflamed equine joint.. In: Proceedings from 21st international conference of racing analyists and veterinarians. 2016. p. 510–5.
  32. Palmer JL, Bertone AL. Experimentally-induced synovitis as a model for acute synovitis in the horse.. Equine Vet J 1994 Nov;26(6):492-5.
    doi: 10.1111/j.2042-3306.1994.tb04056.xpubmed: 7889925google scholar: lookup
  33. Lindegaard C, Gleerup KB, Thomsen MH, Martinussen T, Jacobsen S, Andersen PH. Anti-inflammatory effects of intra-articular administration of morphine in horses with experimentally induced synovitis.. Am J Vet Res 2010 Jan;71(1):69-75.
    doi: 10.2460/ajvr.71.1.69pubmed: 20043783google scholar: lookup
  34. Jacobsen S, Niewold TA, Halling-Thomsen M, Nanni S, Olsen E, Lindegaard C, Andersen PH. Serum amyloid A isoforms in serum and synovial fluid in horses with lipopolysaccharide-induced arthritis.. Vet Immunol Immunopathol 2006 Apr 15;110(3-4):325-30.
    doi: 10.1016/j.vetimm.2005.10.012pubmed: 16337010google scholar: lookup
  35. Campebell RC, Peiro JR, Valadao CAA, Santana AE, Cunha FQ. Effects of lidocaine on lipopolysaccharide-induced synovitis in horses.. Arq Bras Med Vet Zoo 2004;56:281–291.
    doi: 10.1590/S0102-09352004000300001google scholar: lookup
  36. Easter LJ, Watkins JP, Stephens SL, Carter GK, Hague BA. Effects of regional anesthesia on experimentally induced coffin joint synovitis.. In: Proceeding of the annual convention of the AAEP. 2000. p. 214–6.
  37. Medical Products Agency. Dexaject solution for injection. Summary of product characteristics.. 2015.
  38. Keegan KG, Yonezawa Y, Pai PF, Wilson DA, Kramer J. Evaluation of a sensor-based system of motion analysis for detection and quantification of forelimb and hind limb lameness in horses.. Am J Vet Res 2004 May;65(5):665-70.
    doi: 10.2460/ajvr.2004.65.665pubmed: 15141889google scholar: lookup
  39. Kelmer G, Keegan KG, Kramer J, Wilson DA, Pai FP, Singh P. Computer-assisted kinematic evaluation of induced compensatory movements resembling lameness in horses trotting on a treadmill.. Am J Vet Res 2005 Apr;66(4):646-55.
    doi: 10.2460/ajvr.2005.66.646pubmed: 15900946google scholar: lookup
  40. Hewetson M, Christley RM, Hunt ID, Voute LC. Investigations of the reliability of observational gait analysis for the assessment of lameness in horses.. Vet Rec 2006 Jun 24;158(25):852-7.
    doi: 10.1136/vr.158.25.852pubmed: 16798953google scholar: lookup
  41. Keegan KG, Wilson DA, Wilson DJ, Smith B, Gaughan EM, Pleasant RS, Lillich JD, Kramer J, Howard RD, Bacon-Miller C, Davis EG, May KA, Cheramie HS, Valentino WL, van Harreveld PD. Evaluation of mild lameness in horses trotting on a treadmill by clinicians and interns or residents and correlation of their assessments with kinematic gait analysis.. Am J Vet Res 1998 Nov;59(11):1370-7.
    pubmed: 9829392
  42. Arkell M, Archer RM, Guitian FJ, May SA. Evidence of bias affecting the interpretation of the results of local anaesthetic nerve blocks when assessing lameness in horses.. Vet Rec 2006 Sep 9;159(11):346-9.
    doi: 10.1136/vr.159.11.346pubmed: 16963714google scholar: lookup
  43. Hammarberg M, Egenvall A, Pfau T, Rhodin M. Rater agreement of visual lameness assessment in horses during lungeing.. Equine Vet J 2016 Jan;48(1):78-82.
    doi: 10.1111/evj.12385pmc: PMC4964936pubmed: 25399722google scholar: lookup
  44. Ekstrand C, Falkenö U, Kallings P, Tvedten H, Lilliehöök I. Plasma dexamethasone concentration in relation to glucose response in the horse.. J Equine Vet Sci 2019;73:75–80.
    doi: 10.1016/j.jevs.2018.11.008google scholar: lookup
  45. Lapointe JM, Laverty S, Lavoie JP. Septic arthritis in 15 standardbred racehorses after intra-articular injection.. Equine Vet J 1992 Nov;24(6):430-4.
    doi: 10.1111/j.2042-3306.1992.tb02872.xpubmed: 1459055google scholar: lookup
  46. Steel CM, Pannirselvam RR, Anderson GA. Risk of septic arthritis after intra-articular medication: a study of 16,624 injections in Thoroughbred racehorses.. Aust Vet J 2013 Jul;91(7):268-73.
    doi: 10.1111/avj.12073pubmed: 23782019google scholar: lookup
  47. Richardson DW, Dodge GR. Dose-dependent effects of corticosteroids on the expression of matrix-related genes in normal and cytokine-treated articular chondrocytes.. Inflamm Res 2003 Jan;52(1):39-49.
    doi: 10.1007/s000110300012pubmed: 12608648google scholar: lookup
  48. Dechant JE, Baxter GM, Frisbie DD, Trotter GW, McIlwraith CW. Effects of dosage titration of methylprednisolone acetate and triamcinolone acetonide on interleukin-1-conditioned equine articular cartilage explants in vitro.. Equine Vet J 2003 Jul;35(5):444-50.
    doi: 10.2746/042516403775600479pubmed: 12875321google scholar: lookup
  49. Murphy DJ, Todhunter RJ, Fubini SL, Vernier-Singer M, Straubinger RK, Lust G. The effects of methylprednisolone on normal and monocyte-conditioned medium-treated articular cartilage from dogs and horses.. Vet Surg 2000 Nov-Dec;29(6):546-57.
    doi: 10.1053/jvet.2000.17854pubmed: 11098788google scholar: lookup
  50. Tiley HA, Geor RJ, McCutcheon LJ. Effects of dexamethasone on glucose dynamics and insulin sensitivity in healthy horses.. Am J Vet Res 2007 Jul;68(7):753-9.
    doi: 10.2460/ajvr.68.7.753pubmed: 17605611google scholar: lookup
  51. Bailey SR. Corticosteroid-associated laminitis.. Vet Clin North Am Equine Pract 2010 Aug;26(2):277-85.
    doi: 10.1016/j.cveq.2010.04.001pubmed: 20699175google scholar: lookup
  52. Welsh CE, Duz M, Parkin TDH, Marshall JF. Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: A cohort study of free-text electronic medical records.. Prev Vet Med 2017 Jan 1;136:11-18.
    doi: 10.1016/j.prevetmed.2016.11.012pubmed: 28010903google scholar: lookup
  53. Toutain PL, Autefage A, Legrand C, Alvinerie M. Plasma concentrations and therapeutic efficacy of phenylbutazone and flunixin meglumine in the horse: pharmacokinetic/pharmacodynamic modelling.. J Vet Pharmacol Ther 1994 Dec;17(6):459-69.
    doi: 10.1111/j.1365-2885.1994.tb00278.xpubmed: 7707492google scholar: lookup
  54. de Grauw JC, van de Lest CH, Brama PA, Rambags BP, van Weeren PR. In vivo effects of meloxicam on inflammatory mediators, MMP activity and cartilage biomarkers in equine joints with acute synovitis.. Equine Vet J 2009 Sep;41(7):693-9.
    doi: 10.2746/042516409X436286pubmed: 19927589google scholar: lookup
  55. Toutain PL, Cester CC. Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint.. Am J Vet Res 2004 Nov;65(11):1533-41.
    doi: 10.2460/ajvr.2004.65.1533pubmed: 15566092google scholar: lookup
  56. Jeunesse EC, Bargues IA, Toutain CE, Lacroix MZ, Letellier IM, Giraudel JM, Toutain PL. Paw inflammation model in dogs for preclinical pharmacokinetic/pharmacodynamic investigations of nonsteroidal anti-inflammatory drugs.. J Pharmacol Exp Ther 2011 Aug;338(2):548-58.
    doi: 10.1124/jpet.110.178350pubmed: 21525206google scholar: lookup

Citations

This article has been cited 5 times.
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    doi: 10.1186/s12917-022-03537-5pubmed: 36514067google scholar: lookup
  2. Bai H, Yuan R, Zhang Z, Liu L, Wang X, Song X, Ma T, Tang J, Liu C, Gao L. Intra-articular Injection of Baicalein Inhibits Cartilage Catabolism and NLRP3 Inflammasome Signaling in a Posttraumatic OA Model. Oxid Med Cell Longev 2021;2021:6116890.
    doi: 10.1155/2021/6116890pubmed: 34512868google scholar: lookup
  3. Pemmari A, Leppänen T, Hämäläinen M, Moilanen T, Vuolteenaho K, Moilanen E. Widespread regulation of gene expression by glucocorticoids in chondrocytes from patients with osteoarthritis as determined by RNA-Seq. Arthritis Res Ther 2020 Nov 17;22(1):271.
    doi: 10.1186/s13075-020-02289-7pubmed: 33203447google scholar: lookup
  4. Kim KH, Park TS, Cho BW, Kim TM. Nanoparticles from Equine Fetal Bone Marrow-Derived Cells Enhance the Survival of Injured Chondrocytes. Animals (Basel) 2020 Sep 23;10(10).
    doi: 10.3390/ani10101723pubmed: 32977476google scholar: lookup
  5. Duggan MJS, Kearney C, Baltrimaite M, Labberté MC, Gibney R, Brama PAJ. Refinement of the Lipopolysaccharide-Induced Synovitis Model in Equine Middle Carpal Joints. Animals (Basel) 2025 Aug 22;15(17).
    doi: 10.3390/ani15172474pubmed: 40941269google scholar: lookup
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