Distribution of cytosolic oestrogen and progesterone receptors in the genital tract of the mare.

This research investigates the distribution of oestrogen and progesterone receptors in the equine genital tract, with focus on the vagina, cervix and uterus of Polish mares. It shows that the concentrations of these hormones are significantly lower in the vagina and cervix than in the uterus, corroborating data from humans, cattle, and pigs.

Study Background

• The research aims to understand the distribution of oestrogen and progesterone receptors in the genital tract of mares. These receptors are proteins in cells that bind to oestrogen and progesterone, playing a vital role in the reproductive function of mammals.

Research Methodology

• The researchers applied a modified dextran-coated charcoal method to ascertain the distribution of these receptors. This is a specific biochemical method employed for the measurement of steroid hormone receptors.
• They used this method on samples collected from different parts of the genital tract of the mares: the vagina, the cervix, and the uterus.
• The study targeted 30 healthy adult Polish mares, which were divided into two groups based on their serum progesterone levels.

Research Findings

• The concentrations of oestrogen and progesterone receptors turned out to be significantly lower in the vagina and the cervix than in the uterus. This indicates that the uterus has the highest concentration of these receptors in the mare’s genital tract, potentially relating to its direct role in reproduction, particularly gestation.
• These findings are consistent with results from previous research conducted on human beings, cattle, and pigs. In these studies too, the highest concentrations of oestrogen and progesterone receptors were located in the body and the horns of the uterus, respectively.