Distribution of eosinophils and mast cells in the cervical tissue of non-gravid mares during dioestrus.
Abstract: Little is known about the local cellular immune system of the equine cervix. In this study we characterize the distribution of eosinophilic granulocytes and mast cells in the cervical tissue of non-gravid mares during dioestrus. For this purpose cervices of 10 mares were histologically examined after Sirius red and Toluidine blue staining. Both cell types could be found in the lamina propria mucosae. In the tunica muscularis the two cell populations were only rarely detected. No cells could be found in the epithelium mucosae. There was a decreasing cell density from the vaginal to uterine side of the cervix (p < 0.01). Therefore, eosinophils might be a part of the local cellular immune system of the equine cervix during dioestrus, unlike in animals studied so far as cows and rats.
Publication Date: 2005-12-06 PubMed ID: 16324085DOI: 10.1111/j.1439-0531.2005.00627.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The research aims to understand the placement of two types of cells, eosinophils and mast cells, in the cervical tissue of non-pregnant horses during a particular part of their reproductive cycle, called dioestrus. It finds a difference in their distribution when compared to other animals like cows and rats.
Objectives of the Study
- The primary objective of the study was to establish an understanding of the local cellular immune system in the cervical tissue of non-pregnant mares during their dioestrus period, which is a phase in their reproductive cycle.
- To accomplish this, the researchers examined the distribution of eosinophilic granulocytes and mast cells, both significant players in the immune system, in the equine cervix.
Methodology of the Research
- Researchers studied the cervical tissue of 10 mares, staining the tissue samples with Sirius red and Toluidine blue to effectively observe and distinguish the eosinophils and mast cells.
- The cells were then looked for in different layers of the cervical tissue – the lamina propria mucosae (a layer of loose connective tissue), the tunica muscularis (the muscle layer), and the epithelium mucosae (the surface layer).
Results and Findings
- The researchers found both eosinophils and mast cells in the lamina propria mucosae.
- These cells were less frequently seen in the tunica muscularis, and couldn’t be found at all in the epithelium mucosae.
- Additionally, there was observed to be a decrease in cell density from the vaginal side of the cervix to the uterine side, a pattern which was statistically significant.
Conclusions and Significance
- From these results, the researchers concluded that eosinophils might play a part in the local cellular immune system of a non-pregnant mare’s cervix during dioestrus.
- This is notable because it contrasts with the cellular distribution seen in other studied animals, such as cows and rats, indicating a unique aspect of equine reproductive immunology.
Cite This Article
APA
Wehrend A, Huchzermeyer S, Bostedt H.
(2005).
Distribution of eosinophils and mast cells in the cervical tissue of non-gravid mares during dioestrus.
Reprod Domest Anim, 40(6), 562-563.
https://doi.org/10.1111/j.1439-0531.2005.00627.x Publication
Researcher Affiliations
- Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus Liebig University Giessen, Frankfurter Strasse 106, D-35392 Giessen, Germany. axel.wehrend@vetmed.uni-giessen.de
MeSH Terms
- Animals
- Cervix Uteri / cytology
- Diestrus / immunology
- Diestrus / physiology
- Eosinophils / cytology
- Female
- Horses / physiology
- Mast Cells / cytology
- Mucous Membrane / cytology
- Staining and Labeling / veterinary
Citations
This article has been cited 3 times.- Mohamed RH, Yousef NA, Awad M, Mohamed RS, Ali F, Hussein HA, Wehrend A. The relationship between ovarian hormones and mast cell distribution in the ovaries of dromedary camel (Camelus dromedaries) during the follicular wave. Vet World 2023 Feb;16(2):309-316.
- Sikora M, Król J, Nowak M, Stefaniak T, Aubertsson G, Kozdrowski R. The usefulness of uterine lavage and acute phase protein levels as a diagnostic tool for subclinical endometritis in Icelandic mares. Acta Vet Scand 2016 Sep 7;58(1):50.
- Karaca T, Yörük M, Uslu S, Cetin Y, Uslu BA. Distribution of eosinophil granulocytes and mast cells in the reproductive tract of female goats in the preimplantation phase. Vet Res Commun 2009 Aug;33(6):545-54.
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