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Home / Equine Research Bank / Anat Embryol (Berl) / Distribution of SP- and CGRP-like immunoreactive nerve fiber...
Anatomy and embryology1994; 190(5); 469-477; doi: 10.1007/BF00235494

Distribution of SP- and CGRP-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals: evidence for loss during development.

Abstract: The lungs of neonatal foals contain many nerves immunoreactive for substance P and calcitonin gene-related peptide. These nerves are closely associated with the epithelium, bronchial and pulmonary vessels and the airway smooth muscle of all intrathoracic airways, including non-cartilaginous bronchioles. Activation of sensory nerves in the respiratory epithelium could thus potentially affect, via local axon reflexes, vascular and respiratory smooth muscle in neonatal equine airways. Nerves immunoreactive for these peptides are much more widely distributed within the lung than in adult horses; they may thus play a trophic role before birth, or contribute to the post-natal adaptation to breathing.
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Publication Date: 1994-11-01 PubMed ID: 7534051DOI: 10.1007/BF00235494Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper investigates the abundance of nerves sensitive to substance P and calcitonin gene-related peptide in the lungs of newborn foals, how these nerves are distributed throughout the lungs, and how this distribution changes as the foal matures.

Research Objectives and Methods

  • This research aims to understand the distribution, function and development of certain nerves in the lungs of newborn foals.
  • The researchers conducted an examination of substance P (SP) and calcitonin gene-related peptide (CGRP)-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals.
  • By examining these nerves in different parts of the lungs – the epithelium, bronchial and pulmonary vessels, and airway smooth muscle – and how this distribution changes as the foals age, they hoped to gain insights into the nerves’ potential roles in respiratory functions and development.

Key Findings

  • The researchers found that these specific nerve fibers were abundant and widely distributed throughout the lungs of newborn foals. These nerves were found to be closely associated with various structures within the respiratory tract.
  • Activation of these sensory nerves could potentially impact the function of vascular and respiratory smooth muscle in the airways of newborn foals. This could occur via local axon reflexes – a type of neural pathway.
  • Notably, the distribution of these nerves was more extensive in the lungs of newborn foals than in adult horses. This indicates they might play a significant role either before birth or in post-natal respiratory adaptation.
  • However, the abundance of these nerve fibers seemed to decline as the foals matured, indicating a loss during development.

Implications of the Study

  • These findings contribute to our understanding of lung development and function in newborn foals, which could have broader applications in the study of equine health and veterinary science.
  • The evidence of nerve loss during development might be a unique feature to equine lung development, or it could represent a broader physiological phenomenon across other species as well.

Cite This Article

APA
Sonea IM, Bowker RM, Robinson NE, Holland RE. (1994). Distribution of SP- and CGRP-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals: evidence for loss during development. Anat Embryol (Berl), 190(5), 469-477. https://doi.org/10.1007/BF00235494

Publication

Anatomy and embryology
ISSN: 0340-2061
NlmUniqueID: 7505194
Country: Germany
Language: English
Volume: 190
Issue: 5
Pages: 469-477

Researcher Affiliations

Sonea, I M
  • Department of Anatomy, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
Bowker, R M
    Robinson, N E
      Holland, R E

        MeSH Terms

        • Animals
        • Animals, Newborn / anatomy & histology
        • Calcitonin Gene-Related Peptide / analysis
        • Female
        • Horses / anatomy & histology
        • Immunohistochemistry
        • Lung / innervation
        • Male
        • Nerve Fibers / chemistry
        • Substance P / analysis
        • Tachykinins / biosynthesis

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