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Anatomy and embryology1994; 190(5); 469-477; doi: 10.1007/BF00235494

Distribution of SP- and CGRP-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals: evidence for loss during development.

Abstract: The lungs of neonatal foals contain many nerves immunoreactive for substance P and calcitonin gene-related peptide. These nerves are closely associated with the epithelium, bronchial and pulmonary vessels and the airway smooth muscle of all intrathoracic airways, including non-cartilaginous bronchioles. Activation of sensory nerves in the respiratory epithelium could thus potentially affect, via local axon reflexes, vascular and respiratory smooth muscle in neonatal equine airways. Nerves immunoreactive for these peptides are much more widely distributed within the lung than in adult horses; they may thus play a trophic role before birth, or contribute to the post-natal adaptation to breathing.
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Publication Date: 1994-11-01 PubMed ID: 7534051DOI: 10.1007/BF00235494Google Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper investigates the abundance of nerves sensitive to substance P and calcitonin gene-related peptide in the lungs of newborn foals, how these nerves are distributed throughout the lungs, and how this distribution changes as the foal matures.

Research Objectives and Methods

  • This research aims to understand the distribution, function and development of certain nerves in the lungs of newborn foals.
  • The researchers conducted an examination of substance P (SP) and calcitonin gene-related peptide (CGRP)-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals.
  • By examining these nerves in different parts of the lungs – the epithelium, bronchial and pulmonary vessels, and airway smooth muscle – and how this distribution changes as the foals age, they hoped to gain insights into the nerves’ potential roles in respiratory functions and development.

Key Findings

  • The researchers found that these specific nerve fibers were abundant and widely distributed throughout the lungs of newborn foals. These nerves were found to be closely associated with various structures within the respiratory tract.
  • Activation of these sensory nerves could potentially impact the function of vascular and respiratory smooth muscle in the airways of newborn foals. This could occur via local axon reflexes – a type of neural pathway.
  • Notably, the distribution of these nerves was more extensive in the lungs of newborn foals than in adult horses. This indicates they might play a significant role either before birth or in post-natal respiratory adaptation.
  • However, the abundance of these nerve fibers seemed to decline as the foals matured, indicating a loss during development.

Implications of the Study

  • These findings contribute to our understanding of lung development and function in newborn foals, which could have broader applications in the study of equine health and veterinary science.
  • The evidence of nerve loss during development might be a unique feature to equine lung development, or it could represent a broader physiological phenomenon across other species as well.

Cite This Article

APA
Sonea IM, Bowker RM, Robinson NE, Holland RE. (1994). Distribution of SP- and CGRP-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals: evidence for loss during development. Anat Embryol (Berl), 190(5), 469-477. https://doi.org/10.1007/BF00235494

Publication

Anatomy and embryology
ISSN: 0340-2061
NlmUniqueID: 7505194
Country: Germany
Language: English
Volume: 190
Issue: 5
Pages: 469-477

Researcher Affiliations

Sonea, I M
  • Department of Anatomy, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
Bowker, R M
    Robinson, N E
      Holland, R E

        MeSH Terms

        • Animals
        • Animals, Newborn / anatomy & histology
        • Calcitonin Gene-Related Peptide / analysis
        • Female
        • Horses / anatomy & histology
        • Immunohistochemistry
        • Lung / innervation
        • Male
        • Nerve Fibers / chemistry
        • Substance P / analysis
        • Tachykinins / biosynthesis

        References

        This article includes 32 references
        1. Gamse R, Saria A. Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide.. Eur J Pharmacol 1985 Aug 7;114(1):61-6.
          pubmed: 2412851doi: 10.1016/0014-2999(85)90520-5google scholar: lookup
        2. Alving K. Airways vasodilatation in the immediate allergic reaction. Involvement of inflammatory mediators and sensory nerves.. Acta Physiol Scand Suppl 1991;597:1-64.
          pubmed: 2035338
        3. Piedimonte G, Hoffman JI, Husseini WK, Hiser WL, Nadel JA. Effect of neuropeptides released from sensory nerves on blood flow in the rat airway microcirculation.. J Appl Physiol (1985) 1992 Apr;72(4):1563-70.
          pubmed: 1375596doi: 10.1152/jappl.1992.72.4.1563google scholar: lookup
        4. Salonen RO, Webber SE, Widdicombe JG. Effects of neuropeptides and capsaicin on the canine tracheal vasculature in vivo.. Br J Pharmacol 1988 Dec;95(4):1262-70.
          pubmed: 3219486doi: 10.1111/j.1476-5381.1988.tb11763.xgoogle scholar: lookup
        5. Solway J, Leff AR. Sensory neuropeptides and airway function.. J Appl Physiol (1985) 1991 Dec;71(6):2077-87.
          pubmed: 1663932doi: 10.1152/jappl.1991.71.6.2077google scholar: lookup
        6. Haxhiu-Poskurica B, Haxhiu MA, Kumar GK, Miller MJ, Martin RJ. Tracheal smooth muscle responses to substance P and neurokinin A in the piglet.. J Appl Physiol (1985) 1992 Mar;72(3):1090-5.
          pubmed: 1373711doi: 10.1152/jappl.1992.72.3.1090google scholar: lookup
        7. Dhall U, Cowen T, Haven AJ, Burnstock G. Perivascular noradrenergic and peptide-containing nerves show different patterns of changes during development and ageing in the guinea-pig.. J Auton Nerv Syst 1986 Jun;16(2):109-26.
          pubmed: 2424965doi: 10.1016/0165-1838(86)90003-2google scholar: lookup
        8. Tokuyama K, Yokoyama T, Morikawa A, Mochizuki H, Kuroume T, Barnes PJ. Attenuation of tachykinin-induced airflow obstruction and microvascular leakage in immature airways.. Br J Pharmacol 1993 Jan;108(1):23-9.
          pubmed: 7679033doi: 10.1111/j.1476-5381.1993.tb13434.xgoogle scholar: lookup
        9. Martling CR, Saria A, Fischer JA, Hökfelt T, Lundberg JM. Calcitonin gene-related peptide and the lung: neuronal coexistence with substance P, release by capsaicin and vasodilatory effect.. Regul Pept 1988 Feb;20(2):125-39.
          pubmed: 2452458doi: 10.1016/0167-0115(88)90046-8google scholar: lookup
        10. Martling CR, Gazelius B, Lundberg JM. Nervous control of tracheal blood flow in the cat measured by the laser Doppler technique.. Acta Physiol Scand 1987 Jul;130(3):409-17.
          pubmed: 3307302doi: 10.1111/j.1748-1716.1987.tb08156.xgoogle scholar: lookup
        11. Barnes PJ, Baraniuk JN, Belvisi MG. Neuropeptides in the respiratory tract. Part I.. Am Rev Respir Dis 1991 Nov;144(5):1187-98.
          pubmed: 1659270doi: 10.1164/ajrccm/144.5.1187google scholar: lookup
        12. Lundberg JM, Alving K, Karlsson JA, Matran R, Nilsson G. Sensory neuropeptide involvement in animal models of airway irritation and of allergen-evoked asthma.. Am Rev Respir Dis 1991 Jun;143(6):1429-30; discussion 1430-1.
          pubmed: 2048832doi: 10.1164/ajrccm/143.6.1429google scholar: lookup
        13. Hall AK, Barnes PJ, Meldrum LA, Maclagan J. Facilitation by tachykinins of neurotransmission in guinea-pig pulmonary parasympathetic nerves.. Br J Pharmacol 1989 May;97(1):274-80.
          pubmed: 2470459doi: 10.1111/j.1476-5381.1989.tb11951.xgoogle scholar: lookup
        14. Salvi E, Renda T. An immunohistochemical study on neurons and paraneurons of the pre- and post-natal chicken lung.. Arch Histol Cytol 1992 May;55(2):125-35.
          pubmed: 1379825doi: 10.1679/aohc.55.125google scholar: lookup
        15. Sonea IM, Bowker RM, Robinson NE, Broadstone RV. Substance P and calcitonin gene-related peptide-like immunoreactive nerve fibers in lungs from adult equids.. Am J Vet Res 1994 Aug;55(8):1066-74.
          pubmed: 7526754
        16. Worthen GS, Gumbay RS, Tanaka DT, Grunstein MM. Opposing hemodynamic effects of substance P on pulmonary vasculature in rabbits.. J Appl Physiol (1985) 1985 Oct;59(4):1098-103.
          pubmed: 2414267doi: 10.1152/jappl.1985.59.4.1098google scholar: lookup
        17. Le Greves P, Nyberg F, Terenius L, Hökfelt T. Calcitonin gene-related peptide is a potent inhibitor of substance P degradation.. Eur J Pharmacol 1985 Sep 24;115(2-3):309-11.
          pubmed: 2415371doi: 10.1016/0014-2999(85)90706-xgoogle scholar: lookup
        18. Matran R, Alving K, Martling CR, Lacroix JS, Lundberg JM. Effects of neuropeptides and capsaicin on tracheobronchial blood flow of the pig.. Acta Physiol Scand 1989 Mar;135(3):335-42.
          pubmed: 2467519doi: 10.1111/j.1748-1716.1989.tb08547.xgoogle scholar: lookup
        19. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.. Neuroscience 1988 Mar;24(3):739-68.
          pubmed: 3288903doi: 10.1016/0306-4522(88)90064-4google scholar: lookup
        20. Eglezos A, Giuliani S, Viti G, Maggi CA. Direct evidence that capsaicin-induced plasma protein extravasation is mediated through tachykinin NK1 receptors.. Eur J Pharmacol 1991 Dec 17;209(3):277-9.
          pubmed: 1665800doi: 10.1016/0014-2999(91)90183-qgoogle scholar: lookup
        21. Mariassy AT, Gazeroglu H, Wanner A. Morphometry of the subepithelial circulation in sheep airways. Effect of vascular congestion.. Am Rev Respir Dis 1991 Jan;143(1):162-6.
          pubmed: 1986673doi: 10.1164/ajrccm/143.1.162google scholar: lookup
        22. Rogers DF, Belvisi MG, Aursudkij B, Evans TW, Barnes PJ. Effects and interactions of sensory neuropeptides on airway microvascular leakage in guinea-pigs.. Br J Pharmacol 1988 Dec;95(4):1109-16.
          pubmed: 2464389doi: 10.1111/j.1476-5381.1988.tb11745.xgoogle scholar: lookup
        23. Hislop AA, Wharton J, Allen KM, Polak JM, Haworth SG. Immunohistochemical localization of peptide-containing nerves in human airways: age-related changes.. Am J Respir Cell Mol Biol 1990 Sep;3(3):191-8.
          pubmed: 1975191
        24. LeBlanc PH, Broadstone RV, Derksen FJ, Robinson NE. In vitro responses of distal airways in horses with recurrent airway obstruction.. Am J Vet Res 1991 Jul;52(7):999-1003.
          pubmed: 1892280
        25. Tanaka DT, Grunstein MM. Maturation of neuromodulatory effect of substance P in rabbit airways.. J Clin Invest 1990 Feb;85(2):345-50.
          pubmed: 1688882doi: 10.1172/JCI114444google scholar: lookup
        26. Allen KM, Wharton J, Polak JM, Haworth SG. A study of nerves containing peptides in the pulmonary vasculature of healthy infants and children and of those with pulmonary hypertension.. Br Heart J 1989 Nov;62(5):353-60.
          pubmed: 2686736doi: 10.1136/hrt.62.5.353google scholar: lookup
        27. Tanaka DT, Grunstein MM. Effect of substance P on neurally mediated contraction of rabbit airway smooth muscle.. J Appl Physiol (1985) 1986 Feb;60(2):458-63.
          pubmed: 2419300doi: 10.1152/jappl.1986.60.2.458google scholar: lookup
        28. Cadieux A, Springall DR, Mulderry PK, Rodrigo J, Ghatei MA, Terenghi G, Bloom SR, Polak JM. Occurrence, distribution and ontogeny of CGRP immunoreactivity in the rat lower respiratory tract: effect of capsaicin treatment and surgical denervations.. Neuroscience 1986 Oct;19(2):605-27.
          pubmed: 3490633doi: 10.1016/0306-4522(86)90285-xgoogle scholar: lookup
        29. Broadstone RV, LeBlanc PH, Derksen FJ, Robinson NE. In vitro responses of airway smooth muscle from horses with recurrent airway obstruction.. Pulm Pharmacol 1991;4(4):191-202.
          pubmed: 1806132doi: 10.1016/0952-0600(91)90011-qgoogle scholar: lookup
        30. White SR, Hershenson MB, Sigrist KS, Zimmermann A, Solway J. Proliferation of guinea pig tracheal epithelial cells induced by calcitonin gene-related peptide.. Am J Respir Cell Mol Biol 1993 Jun;8(6):592-6.
          pubmed: 8323744doi: 10.1165/ajrcmb/8.6.592google scholar: lookup
        31. Barnes PJ, Baraniuk JN, Belvisi MG. Neuropeptides in the respiratory tract. Part II.. Am Rev Respir Dis 1991 Dec;144(6):1391-9.
          pubmed: 1741554doi: 10.1164/ajrccm/144.6.1391google scholar: lookup
        32. Sonea IM, Bowker RM, Robinson NE, Broadstone RV. Distribution of dopamine beta-hydroxylase and neuropeptide Y-immunoreactive nerves in healthy equine lungs.. Am J Vet Res 1993 Apr;54(4):507-13.
          pubmed: 8484570

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