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Home / Equine Research Bank / Trop Anim Health Prod / Dourine: a neglected disease of equids.
Tropical animal health and production2017; 49(5); 887-897; doi: 10.1007/s11250-017-1280-1

Dourine: a neglected disease of equids.

Abstract: Dourine is a venereal transmitted trypanosomosis causing a major health problem threatening equines worldwide. The origin and identification of Trypanosoma equiperdum within the subgenus Trypanozoon is still a subject of debate. Unlike other trypanosomal infections, dourine is transmitted almost exclusively by coitus. Diagnosis of dourine has continued to be a challenge, due to limited knowledge about the parasite and host-parasite interaction following infection. The pathological lesions caused by the diseases are poorly described and are observed mainly in the reproductive organs, in the nervous system, and on the skin. Dourine has been neglected by research and current knowledge on the disease, and the parasite is very deficient despite its considerably high burden. This paper looks in to the challenges in identification of T. equiperdum and diagnosis techniques with the aim to update our current knowledge of the disease.
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Publication Date: 2017-04-24 PubMed ID: 28439783PubMed Central: PMC5432633DOI: 10.1007/s11250-017-1280-1Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article takes a closer look at Dourine, a sexually transmitted disease affecting equines worldwide caused by the Trypanosoma equiperdum parasite. The study delves into numerous challenges in the identification and diagnosis of this disease, whose pathological descriptions and impact are not fully known, despite its high toll on equines.

Debates Surrounding Trypanosoma equiperdum

  • The article acknowledges an ongoing debate about the origin and identification of Trypanosoma equiperdum, the parasite responsible for Dourine, a disease which broadly falls under trypanosomosis.
  • This debate centers on how this specific parasite fits within the larger subgenus Trypanozoon. The identification process is complex and can potentially impact strategies for disease management and treatment.

Method of Disease Transmission

  • Different from other types of trypanosomal infections, Dourine is primarily spread through sexual contact among equines.
  • This transmission mode presents unique challenges in terms of disease control, necessitating specific behavioral and breeding changes in populations of equines.

Challenges in Dourine Diagnosis

  • Diagnostics for Dourine is difficult due to limited information about the behavior and interaction of the parasite with its host post-infection. This fact underscores the gaps existing in the current understanding of the disease.
  • These gaps in knowledge contribute to the poor description of the pathological lesions caused by Dourine.

Focus on Pathological Lesions

  • Observations indicate that the lesions caused by Dourine primarily affect the reproductive organs, nervous system, and skin of equines. More investigation and characterization of these effects are needed for disease management and treatment measures.

Need for Further Research

  • Despite the considerable health burden this disease places on the equine population worldwide, it remains neglected in research.
  • The authors argue that more resources need to be directed to the investigation of this disease and its causative parasite to alleviate its substantial impact on global equine health.

Objective of the Study

  • The study intends to shed light on the existing challenges regarding the identification of T. equiperdum, and the available diagnostic techniques for Dourine.
  • By addressing these challenges, the researchers aim to enhance present understanding of the disease, thereby contributing to the improvement of diagnostic and treatment approaches.

Cite This Article

APA
Gizaw Y, Megersa M, Fayera T. (2017). Dourine: a neglected disease of equids. Trop Anim Health Prod, 49(5), 887-897. https://doi.org/10.1007/s11250-017-1280-1

Publication

Tropical animal health and production
ISSN: 1573-7438
NlmUniqueID: 1277355
Country: United States
Language: English
Volume: 49
Issue: 5
Pages: 887-897

Researcher Affiliations

Gizaw, Yonas
  • College of Veterinary Medicine, Jigjiga University, P. O. Box: 1020, Jigjiga, Ethiopia.
Megersa, Mulisa
  • College of Veterinary Medicine, Jigjiga University, P. O. Box: 1020, Jigjiga, Ethiopia. mulisam38@gmail.com.
Fayera, Teka
  • College of Veterinary Medicine, Jigjiga University, P. O. Box: 1020, Jigjiga, Ethiopia.

MeSH Terms

  • Animals
  • Dourine / diagnosis
  • Dourine / epidemiology
  • Dourine / parasitology
  • Horse Diseases / diagnosis
  • Horse Diseases / epidemiology
  • Horse Diseases / parasitology
  • Horses
  • Neglected Diseases / diagnosis
  • Neglected Diseases / epidemiology
  • Neglected Diseases / parasitology
  • Neglected Diseases / veterinary
  • Trypanosoma / classification
  • Trypanosoma / physiology

Conflict of Interest Statement

The authors declare that they have no conflict of interest.

References

This article includes 67 references
  1. Agbo EE, Majiwa PA, Claassen HJ, te Pas MF. Molecular variation of Trypanosoma brucei subspecies as revealed by AFLP fingerprinting.. Parasitology 2002 Apr;124(Pt 4):349-58.
    doi: 10.1017/S003118200100138Xpubmed: 12003059google scholar: lookup
  2. Alemu T, Luckins AG, Phipps LP, Reid SW, Holmes PH. The use of enzyme linked immunosorbent assays to investigate the prevalence of Trypanosoma equiperdum in Ethiopian horses.. Vet Parasitol 1997 Aug;71(4):239-50.
    doi: 10.1016/S0304-4017(96)01139-9pubmed: 9299693google scholar: lookup
  3. Barrowman PR. Experimental intraspinal trypanosoma equiperdum infection in a horse.. Onderstepoort J Vet Res 1976 Dec;43(4):201-2.
    pubmed: 1023092
  4. Becker S, Franco JR, Simarro PP, Stich A, Abel PM, Steverding D. Real-time PCR for detection of Trypanosoma brucei in human blood samples.. Diagn Microbiol Infect Dis 2004 Nov;50(3):193-9.
    doi: 10.1016/j.diagmicrobio.2004.07.001pubmed: 15541605google scholar: lookup
  5. Berlin D, Loeb E, Baneth G. Disseminated central nervous system disease caused by Trypanosoma evansi in a horse.. Vet Parasitol 2009 May 12;161(3-4):316-9.
    doi: 10.1016/j.vetpar.2009.01.030pubmed: 19251368google scholar: lookup
  6. Bishop S, Rae PF, Phipps LP, Boid R, Luckins AG. Trypanosoma equiperdum: detection of trypanosomal antibodies and antigen by enzyme-linked immunosorbent assay.. Br Vet J 1995 Nov-Dec;151(6):715-20.
    doi: 10.1016/S0007-1935(95)80152-9pubmed: 8605584google scholar: lookup
  7. Borst P, Fase-Fowler F, Gibson WC. Kinetoplast DNA of Trypanosoma evansi.. Mol Biochem Parasitol 1987 Feb;23(1):31-8.
    doi: 10.1016/0166-6851(87)90184-8pubmed: 3033499google scholar: lookup
  8. Brun R, Hecker H, Lun ZR. Trypanosoma evansi and T. equiperdum: distribution, biology, treatment and phylogenetic relationship (a review).. Vet Parasitol 1998 Oct;79(2):95-107.
    doi: 10.1016/S0304-4017(98)00146-0pubmed: 9806490google scholar: lookup
  9. Brun R, Lun ZR. Drug sensitivity of Chinese Trypanosoma evansi and Trypanosoma equiperdum isolates.. Vet Parasitol 1994 Mar;52(1-2):37-46.
    doi: 10.1016/0304-4017(94)90033-7pubmed: 8030186google scholar: lookup
  10. Büscher P, Mumba Ngoyi D, Kaboré J, Lejon V, Robays J, Jamonneau V, Bebronne N, Van der Veken W, Biéler S. Improved Models of Mini Anion Exchange Centrifugation Technique (mAECT) and Modified Single Centrifugation (MSC) for sleeping sickness diagnosis and staging.. PLoS Negl Trop Dis 2009 Nov 24;3(11):e471.
    doi: 10.1371/journal.pntd.0000471pmc: PMC2775158pubmed: 19936296google scholar: lookup
  11. Calistri P, Narcisi V, Atzeni M, De Massis F, Tittarelli M, Mercante MT, Ruggieri E, Scacchia M. Dourine Reemergence in Italy. Journal of Equine Veterinary Science 2013;33:83–89.
    doi: 10.1016/j.jevs.2012.05.057google scholar: lookup
  12. Chin SW, Uppal PK, PremaAlatha B, Chandrawathani P, Norazura AH, Ramlan M. Freedom status of dourine (Trypanosoma equiperdum) in Malaysia. Malaysian Journal of Veterinary Research 2013;4(2):61–64.
  13. Ciuca A. La dourine. Bulletin - Office International Des Epizooties 1933;7:168–172.
  14. Claes F, Agbo EC, Radwanska M, Te Pas MF, Baltz T, De Waal DT, Goddeeris BM, Claassen E, Büscher P. How does Trypanosoma equiperdum fit into the Trypanozoon group? A cluster analysis by RAPD and multiplex-endonuclease genotyping approach.. Parasitology 2003 May;126(Pt 5):425-31.
    doi: 10.1017/S0031182003002968pubmed: 12793646google scholar: lookup
  15. Claes F, Büscher P, Touratier L, Goddeeris BM. Trypanosoma equiperdum: master of disguise or historical mistake?. Trends Parasitol 2005 Jul;21(7):316-21.
    doi: 10.1016/j.pt.2005.05.010pubmed: 15923142google scholar: lookup
  16. Claes F, Radwanska M, Urakawa T, Majiwa PA, Goddeeris B, Büscher P. Variable Surface Glycoprotein RoTat 1.2 PCR as a specific diagnostic tool for the detection of Trypanosoma evansi infections.. Kinetoplastid Biol Dis 2004 Sep 17;3(1):3.
    doi: 10.1186/1475-9292-3-3pmc: PMC521498pubmed: 15377385google scholar: lookup
  17. Clausen PH, Chuluun S, Sodnomdarjaa R, Greiner M, Noeckler K, Staak C, Zessin KH, Schein E. A field study to estimate the prevalence of Trypanosoma equiperdum in Mongolian horses.. Vet Parasitol 2003 Jul 10;115(1):9-18.
    doi: 10.1016/S0304-4017(03)00160-2pubmed: 12860063google scholar: lookup
  18. Clausen PH, Gebreselassie G, Abditcho S, Mehlitz D, Staak C. Detection of trypanosome DNA in serologically positive but aparasitaemic horses suspected of dourine in Ethiopia.. Tokai J Exp Clin Med 1998 Dec;23(6):303-8.
    pubmed: 10622626
  19. Gari FR, Ashenafi H, Tola A, Goddeeris BM, Claes F. Comparative diagnosis of parasitological, serological, and molecular tests in dourine-suspected horses.. Trop Anim Health Prod 2010 Dec;42(8):1649-54.
    doi: 10.1007/s11250-010-9615-1pubmed: 20526860google scholar: lookup
  20. Gibson W. Resolution of the species problem in African trypanosomes.. Int J Parasitol 2007 Jul;37(8-9):829-38.
    doi: 10.1016/j.ijpara.2007.03.002pubmed: 17451719google scholar: lookup
  21. Hagebock JM, Chieves L, Frerichs WM, Miller CD. Evaluation of agar gel immunodiffusion and indirect fluorescent antibody assays as supplemental tests for dourine in equids.. Am J Vet Res 1993 Aug;54(8):1201-8.
    pubmed: 8214884
  22. Hagos A, Abebe G, Büscher P, Goddeeris BM, Claes F. Serological and parasitological survey of dourine in the Arsi-Bale highlands of Ethiopia.. Trop Anim Health Prod 2010 Apr;42(4):769-76.
    doi: 10.1007/s11250-009-9485-6pubmed: 19924557google scholar: lookup
  23. Hagos A, Goddeeris BM, Yilkal K, Alemu T, Fikru R, Yacob HT, Feseha G, Claes F. Efficacy of Cymelarsan and Diminasan against Trypanosoma equiperdum infections in mice and horses.. Vet Parasitol 2010 Aug 4;171(3-4):200-6.
    doi: 10.1016/j.vetpar.2010.03.041pubmed: 20417035google scholar: lookup
  24. Hébert L, Moumen B, Madeline A, Steinbiss S, Lakhdar L, Van Reet N, Büscher P, Laugier C, Cauchard J, Petry S. First Draft Genome Sequence of the Dourine Causative Agent: Trypanosoma Equiperdum Strain OVI.. J Genomics 2017;5:1-3.
    doi: 10.7150/jgen.17904pmc: PMC5278650pubmed: 28138343google scholar: lookup
  25. Hoare CA. The trypanosomes of mammals. Oxford: Blackwell scientific publications; 1972. pp. 1–749.
  26. Katz JB, Chieves LP, Hennager SG, Nicholson JM, Fisher TA, Byers PE. Serodiagnosis of equine piroplasmosis, dourine, and glanders using an arrayed immunoblotting method.. J Vet Diagn Invest 1999 May;11(3):292-4.
    doi: 10.1177/104063879901100316pubmed: 10353365google scholar: lookup
  27. Kumba FF, Claasen B, Petrus P. Apparent prevalence of dourine in the Khomas region of Namibia.. Onderstepoort J Vet Res 2002 Dec;69(4):295-8.
    pubmed: 12625381
  28. Lai DH, Hashimi H, Lun ZR, Ayala FJ, Lukes J. Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei.. Proc Natl Acad Sci U S A 2008 Feb 12;105(6):1999-2004.
    pmc: PMC2538871pubmed: 18245376doi: 10.1073/pnas.0711799105google scholar: lookup
  29. Li FJ, Gasser RB, Zheng JY, Claes F, Zhu XQ, Lun ZR. Application of multiple DNA fingerprinting techniques to study the genetic relationships among three members of the subgenus Trypanozoon (Protozoa: Trypanosomatidae).. Mol Cell Probes 2005 Dec;19(6):400-7.
    doi: 10.1016/j.mcp.2005.07.002pubmed: 16146682google scholar: lookup
  30. Luckins AG. Equine trypanosomiasis. Equine Veterinary Education 1994;6(5):259–262.
    doi: 10.1111/j.2042-3292.1994.tb01149.xgoogle scholar: lookup
  31. Luckins, A.G., Barrowman, P.R., Stoltsz, W.H. and Van Der Lugt, J.J., 2004. In: Coetzer, J.A.W., Tustin, R.C. (Eds.), Dourine. Infectious Disease of Livestock, 2nd ed. (Oxford University Press (SA), Cape Town).
  32. Lun ZR, Brun R, Gibson W. Kinetoplast DNA and molecular karyotypes of Trypanosoma evansi and Trypanosoma equiperdum from China.. Mol Biochem Parasitol 1992 Feb;50(2):189-96.
    doi: 10.1016/0166-6851(92)90215-6pubmed: 1311051google scholar: lookup
  33. Lun ZR, Desser SS. Is the broad range of hosts and geographical distribution of Trypanosoma evansi attributable to the loss of maxicircle kinetoplast DNA?. Parasitol Today 1995 Apr;11(4):131-3.
    doi: 10.1016/0169-4758(95)80129-4pubmed: 15275353google scholar: lookup
  34. Lun ZR, Lai DH, Li FJ, Lukes J, Ayala FJ. Trypanosoma brucei: two steps to spread out from Africa.. Trends Parasitol 2010 Sep;26(9):424-7.
    doi: 10.1016/j.pt.2010.05.007pubmed: 20561822google scholar: lookup
  35. Lun ZR, Li AX, Chen XG, Lu LX, Zhu XQ. Molecular profiles of Trypanosoma brucei, T. evansi and T. equiperdum stocks revealed by the random amplified polymorphic DNA method.. Parasitol Res 2004 Mar;92(4):335-40.
    doi: 10.1007/s00436-003-1054-8pubmed: 14727188google scholar: lookup
  36. MacLeod A, Welburn S, Maudlin I, Turner CM, Tait A. Evidence for multiple origins of human infectivity in Trypanosoma brucei revealed by minisatellite variant repeat mapping.. J Mol Evol 2001 Mar;52(3):290-301.
    doi: 10.1007/s002390010157pubmed: 11428466google scholar: lookup
  37. Masupu KV, Majok AA. Apparent prevalence of equine dourine in Kgalagadi district of Botswana. Zimbabwe Veterinary Journal 1998;29:113–116.
    doi: 10.4314/zvj.v29i4.5335google scholar: lookup
  38. Maudlin I, Holmes PH, Miles MA. The trypanosomiasis. Oxfordshire: CABI Publishing; 2004.
  39. Murray M, Clifford DJ, McIntyre WI. Diagnosis of African trypanosomiasis in the bovine.. Trans R Soc Trop Med Hyg 1979;73(1):120-1.
    doi: 10.1016/0035-9203(79)90148-2pubmed: 442172google scholar: lookup
  40. Njiru ZK, Mikosza AS, Matovu E, Enyaru JC, Ouma JO, Kibona SN, Thompson RC, Ndung'u JM. African trypanosomiasis: sensitive and rapid detection of the sub-genus Trypanozoon by loop-mediated isothermal amplification (LAMP) of parasite DNA.. Int J Parasitol 2008 Apr;38(5):589-99.
    doi: 10.1016/j.ijpara.2007.09.006pmc: PMC7094514pubmed: 17991469google scholar: lookup
  41. OIE. Dourine. Manual of diagnostic tests and vaccines for terrestrial animals 2008; 845–851.
  42. OIE. Trypanosomosis (tsetse-transmitted). Terrestrial Manual Paris: Office International des Epizooties (OIE); 2013.
  43. Pascucci I, Di Provvido A, Cammà C, Di Francesco G, Calistri P, Tittarelli M, Ferri N, Scacchia M, Caporale V. Diagnosis of dourine in outbreaks in Italy.. Vet Parasitol 2013 Mar 31;193(1-3):30-8.
    doi: 10.1016/j.vetpar.2012.12.006pubmed: 23298562google scholar: lookup
  44. Radwanska M, Magez S, Perry-O'Keefe H, Stender H, Coull J, Sternberg JM, Büscher P, Hyldig-Nielsen JJ. Direct detection and identification of African trypanosomes by fluorescence in situ hybridization with peptide nucleic acid probes.. J Clin Microbiol 2002 Nov;40(11):4295-7.
    doi: 10.1128/JCM.40.11.4295-4297.2002pmc: PMC139669pubmed: 12409413google scholar: lookup
  45. Reid SA, Husein A, Copeman DB. Evaluation and improvement of parasitological tests for Trypanosoma evansi infection.. Vet Parasitol 2001 Dec 28;102(4):291-7.
    doi: 10.1016/S0304-4017(01)00539-8pubmed: 11731072google scholar: lookup
  46. Rouget J. Contribution a l’ étude du trypanosome des mammifere. Annales de l’Institut Pasteur 1986;10:716–728.
  47. Scacchia M, Cammà C, Di Francesco G, Di Provvido A, Giunta R, Luciani M, Marino AM, Pascucci I, Caporale V. A clinical case of dourine in an outbreak in Italy.. Vet Ital 2011 Oct-Dec;47(4):473-5, 469-72.
    pubmed: 22194229
  48. Sidney R, Andrew McG, James C, Richard N. Dourine – an emerging venereal threat to European horses. AHT / BEVA/DEFrA Equine Quarterly Disease Surveillance report 2013;6, 7.
  49. Stephen LE. Trypanosomiasis, a veterinary perspective. Oxford: Pergamon Press; 1986.
  50. Suganuma K, Narantsatsral S, Battur B, Yamasaki S, Otgonsuren D, Musinguzi SP, Davaasuren B, Battsetseg B, Inoue N. Isolation, cultivation and molecular characterization of a new Trypanosoma equiperdum strain in Mongolia.. Parasit Vectors 2016 Aug 31;9(1):481.
    doi: 10.1186/s13071-016-1755-3pmc: PMC5007690pubmed: 27580944google scholar: lookup
  51. Theis JH, Bolton V. Trypanosoma equiperdum: movement from the dermis.. Exp Parasitol 1980 Dec;50(3):317-30.
    doi: 10.1016/0014-4894(80)90035-1pubmed: 7428909google scholar: lookup
  52. Thekisoe OM, Kuboki N, Nambota A, Fujisaki K, Sugimoto C, Igarashi I, Yasuda J, Inoue N. Species-specific loop-mediated isothermal amplification (LAMP) for diagnosis of trypanosomosis.. Acta Trop 2007 Jun;102(3):182-9.
    doi: 10.1016/j.actatropica.2007.05.004pubmed: 17574198google scholar: lookup
  53. Vaysse J, Zottner G. Contribution a letude de la chimiotherapie et de la chimioprevention de la dourine par l’antracyde. Bulletin - Office International Des Epizooties 1950;34:172–179.
  54. Verloo D, Magnus E, Büscher P. General expression of RoTat 1.2 variable antigen type in Trypanosoma evansi isolates from different origin.. Vet Parasitol 2001 Jun 12;97(3):183-9.
    doi: 10.1016/S0304-4017(01)00412-5pubmed: 11390070google scholar: lookup
  55. Vulpiani MP, Carvelli A, Giansante D, Iannino F, Paganico D, Ferri N. Reemergence of dourine in Italy: clinical cases in some positive horses. Journal of Equine Veterinary Science 2013;33:468–474.
    doi: 10.1016/j.jevs.2012.07.010google scholar: lookup
  56. Waitumbi JN, Murphy NB. Inter- and intra-species differentiation of trypanosomes by genomic fingerprinting with arbitrary primers.. Mol Biochem Parasitol 1993 Mar;58(1):181-5.
    doi: 10.1016/0166-6851(93)90105-7pubmed: 8459833google scholar: lookup
  57. Wang ZL. The similarities and differences of the characteristics between T. equiperdum and T. evansi. Bul. Vet. Col. (PLA) (Chinese) 1988;8:300–303.
  58. Wassall DA, Gregory RJ, Phipps LP. Comparative evaluation of enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of dourine.. Vet Parasitol 1991 Aug;39(3-4):233-9.
    doi: 10.1016/0304-4017(91)90040-3pubmed: 1957484google scholar: lookup
  59. Watson EA. Dourine in Canada, 1904–1920: History, research and suppression. Dominion of Canada. Ottawa: Department of Agriculture, Heath of Animals Branch; 1920.
  60. Wei Y, Wen Y, Desquesnes M, Zhao-Rong L. Molecular epidemiology of T. evansi and T. equiperdum and atypical human infection by animal trypanosomes. Madame Curie Report 2011.
  61. William BL, Steven HS. Infectious diseases of breeding stallion in: Current Therapy in Large Animal Theriogenology (2nd Ed.). 2007; pp. 15–23.
  62. Williamson CC, Stoltsz WH, Mattheus A, Schiele GJ. An investigation into alternative methods for the serodiagnosis of dourine.. Onderstepoort J Vet Res 1988 Jun;55(2):117-9.
    pubmed: 3292986
  63. Yonas G. Clinical signs, serum biochemical profiles and reproductive pathological lesions in horses naturally infected with dourine in Western Arsi zone, Ethiopia. 2015 (unpublished MSc thesis, Addis Ababa University).
  64. Zablotskij VT, Georgiu C, de Waal T, Clausen PH, Claes F, Touratier L. The current challenges of dourine: difficulties in differentiating Trypanosoma equiperdum within the subgenus Trypanozoon.. Rev Sci Tech 2003 Dec;22(3):1087-96.
    pubmed: 15005565doi: 10.20506/rst.22.3.1460google scholar: lookup
  65. Zhang ZQ, Baltz T. Identification of Trypanosoma evansi, Trypanosoma equiperdum and Trypanosoma brucei brucei using repetitive DNA probes.. Vet Parasitol 1994 Jun;53(3-4):197-208.
    doi: 10.1016/0304-4017(94)90183-Xpubmed: 7975115google scholar: lookup
  66. Zhang ZQ, Giroud C, Baltz T. In vivo and in vitro sensitivity of Trypanosoma evansi and T. equiperdum to diminazene, suramin, MelCy, quinapyramine and isometamidium.. Acta Trop 1991 Dec;50(2):101-10.
    doi: 10.1016/0001-706X(91)90002-2pubmed: 1685865google scholar: lookup
  67. Zwart D. Aspects of comparative pathology and pathogenesis of trypanosomal infections in Africa.. Ann Soc Belg Med Trop 1989 Jun;69(2):105-12.
    pubmed: 2679450

Citations

This article has been cited 14 times.
  1. Ungogo MA, Aldfer MM, Natto MJ, Zhuang H, Chisholm R, Walsh K, McGee M, Ilbeigi K, Asseri JI, Burchmore RJS, Caljon G, Van Calenbergh S, De Koning HP. Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis.. Int J Mol Sci 2023 Feb 5;24(4).
    doi: 10.3390/ijms24043144pubmed: 36834557google scholar: lookup
  2. Desquesnes M, Sazmand A, Gonzatti M, Boulangé A, Bossard G, Thévenon S, Gimonneau G, Truc P, Herder S, Ravel S, Sereno D, Waleckx E, Jamonneau V, Jacquiet P, Jittapalapong S, Berthier D, Solano P, Hébert L. Diagnosis of animal trypanosomoses: proper use of current tools and future prospects.. Parasit Vectors 2022 Jun 27;15(1):235.
    doi: 10.1186/s13071-022-05352-1pubmed: 35761373google scholar: lookup
  3. Suganuma K, N'Da DD, Watanabe KI, Tanaka Y, Mossaad E, Elata A, Inoue N, Kawazu SI. Therapeutic Efficacy of Orally Administered Nitrofurantoin against Animal African Trypanosomosis Caused by Trypanosoma congolense Infection.. Pathogens 2022 Mar 9;11(3).
    doi: 10.3390/pathogens11030331pubmed: 35335655google scholar: lookup
  4. Tanaka Y, Suganuma K, Watanabe K, Kobayashi Y. Pathology of female mice experimentally infected with an in vitro cultured strain of Trypanosoma equiperdum.. J Vet Med Sci 2021 Aug 6;83(8):1212-1218.
    doi: 10.1292/jvms.21-0056pubmed: 34135196google scholar: lookup
  5. Magri A, Galuppi R, Fioravanti M. Autochthonous Trypanosoma spp. in European Mammals: A Brief Journey amongst the Neglected Trypanosomes.. Pathogens 2021 Mar 13;10(3).
    doi: 10.3390/pathogens10030334pubmed: 33805748google scholar: lookup
  6. Di Febo T, Krasteva I, Bonfini B, Tittarelli M, Matteucci O, Orsini G, Rossi E, Podaliri Vulpiani M, Rodomonti D, Iannetti L, Luciani M. Humoral immune response and delayed-type hypersensitivity in rabbits infected with Trypanosoma equiperdum.. Sci Rep 2020 Sep 10;10(1):14914.
    doi: 10.1038/s41598-020-71992-xpubmed: 32913248google scholar: lookup
  7. Gummery L, Jallow S, Raftery AG, Bennet E, Rodgers J, Sutton DGM. Comparison of loop-mediated isothermal amplification (LAMP) and PCR for the diagnosis of infection with Trypanosoma brucei ssp. in equids in The Gambia.. PLoS One 2020;15(8):e0237187.
    doi: 10.1371/journal.pone.0237187pubmed: 32833981google scholar: lookup
  8. Mizushima D, Amgalanbaatar T, Davaasuren B, Kayano M, Naransatsral S, Myagmarsuren P, Otgonsuren D, Enkhtaivan B, Davkharbayar B, Mungun-Ochir B, Baatarjargal P, Nyamdolgor U, Soyolmaa G, Altanchimeg A, Zoljargal M, Nguyen TT, Battsetseg B, Battur B, Inoue N, Yokoyama N, Suganuma K. Nationwide serological surveillance of non-tsetse-transmitted horse trypanosomoses in Mongolia.. Parasite Epidemiol Control 2020 Aug;10:e00158.
    doi: 10.1016/j.parepi.2020.e00158pubmed: 32642568google scholar: lookup
  9. Ashby B. Antagonistic coevolution between hosts and sexually transmitted infections.. Evolution 2020 Jan;74(1):43-56.
    doi: 10.1111/evo.13883pubmed: 31732970google scholar: lookup
  10. Mehlitz D, Molyneux DH. The elimination of Trypanosoma brucei gambiense? Challenges of reservoir hosts and transmission cycles: Expect the unexpected.. Parasite Epidemiol Control 2019 Aug;6:e00113.
    doi: 10.1016/j.parepi.2019.e00113pubmed: 31528738google scholar: lookup
  11. Yasine A, Ashenafi H, Geldhof P, Van Brantegem L, Vercauteren G, Bekana M, Tola A, Van Soom A, Duchateau L, Goddeeris B, Govaere J. Histopathological lesions in reproductive organs, distal spinal cord and peripheral nerves of horses naturally infected with Trypanosoma equiperdum.. BMC Vet Res 2019 May 28;15(1):175.
    doi: 10.1186/s12917-019-1916-7pubmed: 31138270google scholar: lookup
  12. Silva Pereira S, Trindade S, De Niz M, Figueiredo LM. Tissue tropism in parasitic diseases.. Open Biol 2019 May 31;9(5):190036.
    doi: 10.1098/rsob.190036pubmed: 31088251google scholar: lookup
  13. Parra-Gimenez N, Reyna-Bello A. Parasitological, Hematological, and Immunological Response of Experimentally Infected Sheep with Venezuelan Isolates of Trypanosoma evansi, Trypanosoma equiperdum, and Trypanosoma vivax.. J Parasitol Res 2019;2019:8528430.
    doi: 10.1155/2019/8528430pubmed: 30881699google scholar: lookup
  14. McCulloch R, Cobbold CA, Figueiredo L, Jackson A, Morrison LJ, Mugnier MR, Papavasiliou N, Schnaufer A, Matthews K. Emerging challenges in understanding trypanosome antigenic variation.. Emerg Top Life Sci 2017 Dec 22;1(6):585-592.
    doi: 10.1042/ETLS20170104pubmed: 30271884google scholar: lookup
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