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Home / Equine Research Bank / Front Vet Sci / Dynamic changes of gut fungal community in horse at differen...
Frontiers in veterinary science2022; 9; 1047412; doi: 10.3389/fvets.2022.1047412

Dynamic changes of gut fungal community in horse at different health states.

Abstract: Accumulating studies indicated that gut microbial changes played key roles in the progression of multiple diseases, which seriously threaten the host health. Gut microbial dysbiosis is closely associated with the development of diarrhea, but gut microbial composition and variability in diarrheic horses have not been well characterized. Here, we investigated gut fungal compositions and changes in healthy and diarrheic horses using amplicon sequencing. Results indicated that the alpha and beta diversities of gut fungal community in diarrheal horses changed significantly, accompanied by distinct changes in taxonomic compositions. The types of main fungal phyla (, and ) in healthy and diarrheal horses were same but different in relative abundances. However, the species and abundances of dominant fungal genera in diarrheal horses changed significantly compared with healthy horses. Results of Metastats analysis indicated that all differential fungal phyla (, and ) showed a decreasing trend during diarrhea. Moreover, a total of 175 differential fungal genera were identified for the gut fungal community between healthy and diarrheal horses, where 4 fungal genera increased significantly, 171 bacterial genera decreased dramatically during diarrhea. Among these decreased bacteria, 74 fungal genera even completely disappeared from the intestine. Moreover, this is the first comparative analysis of equine gut fungal community in different health states, which is beneficial to understand the important role of gut fungal community in equine health.
Copyright © 2022 Lan, Li, Yu, Zhang and Irshad.
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Publication Date: 2022-10-28 PubMed ID: 36387410PubMed Central: PMC9650549DOI: 10.3389/fvets.2022.1047412Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper focuses on examining the variations in the gut fungal community of horses when they are healthy and when they suffer from diarrhea. The study uses amplicon sequencing to unveil these changes and examine any relationships with the horse’s health.

Methodology

  • The researchers studied the gut fungal compositions and changes in both healthy horses and those with diarrhea.
  • To examine the fungal communities, they used amplicon sequencing, a process where DNA sequencing is used to identify various microbes present in the horse’s gut.

Main Findings

  • The study found significant changes in the alpha and beta diversities of the gut fungal community in horses suffering from diarrhea.
  • They noticed significant changes in taxonomic compositions in these horses compared to healthy ones.
  • The primary fungal phyla present in healthy and diarrheic horses were the same, but their relative abundances differed.
  • The species and their abundance of dominant fungal genera changed considerably in horses suffering from diarrhea compared to those in a healthy state.

Statistical Analysis

  • Metastats analysis showed that all different fungal phyla showed a decreasing trend during a bout of diarrhea.
  • A total of 175 differing fungal genera were identified as part of the gut microbial community between healthy horses and those suffering from diarrhea.
  • Of these detected genera, four showed a significant increase, while the remaining 171 genera decreased dramatically during diarrhea episodes.
  • Among the fungi that decreased, 74 genera were completely wiped out from the gut during diarrhea.

Significance of the Findings

  • This is the first study that comparatively analyzed the equine gut fungal community in varying health states.
  • The findings help deepen the understanding of the significant role the gut fungal community plays in horse health and disease.

Cite This Article

APA
Lan Y, Li Y, Yu G, Zhang Z, Irshad I. (2022). Dynamic changes of gut fungal community in horse at different health states. Front Vet Sci, 9, 1047412. https://doi.org/10.3389/fvets.2022.1047412

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 9
Pages: 1047412
PII: 1047412

Researcher Affiliations

Lan, Yanfang
  • School of Physical Education and International Equestrianism, Wuhan Business University, Wuhan, China.
Li, Yaonan
  • School of Physical Education and International Equestrianism, Wuhan Business University, Wuhan, China.
Yu, Gang
  • School of Physical Education and International Equestrianism, Wuhan Business University, Wuhan, China.
Zhang, Zhengyi
  • School of Physical Education and International Equestrianism, Wuhan Business University, Wuhan, China.
Irshad, Irfan
  • Pathobiology Section, Institute of Continuing Education and Extension, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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