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Home / Equine Research Bank / J Vet Intern Med / Effect of a long-term high-energy diet on cardiovascular par...
Journal of veterinary internal medicine2021; 35(5); 2427-2436; doi: 10.1111/jvim.16229

Effect of a long-term high-energy diet on cardiovascular parameters in Shetland pony mares.

Abstract: Changes in cardiovascular parameters, including blood pressure (BP) and cardiac anatomical dimensions, are an inconsistent feature of the equine metabolic syndrome. The order in which these changes arise is unknown. Objective: Determine the order in which EMS-associated changes in cardiovascular parameters arise. Methods: Twenty Shetland pony mares. Methods: High-energy (HE) diet mares were fed 200% of net energy requirements for 1 (n = 3) or 2 (n = 7) consecutive diet-years, with 17 weeks of hay-only between years. Noninvasive BP measurements and echocardiograms were performed during both years. Resting 24-hour ECGs and measurements of autonomic tone (splenic volume and packed cell volume [PCV]) were performed at the end of diet-year 1. Results were compared to control mares receiving a maintenance diet for 1 (n = 7) or 2 (n = 3) consecutive years. Results: In year 1, HE mares had significantly higher values than control mares for mean relative left ventricular wall thickness (P = .001). After 2 diet-years, mean systolic (P = .003), diastolic (P < .001) and mean arterial BP (P = .001), heart rate (HR; P < .001), and mean left ventricular wall thickness (P = .001) also were significantly increased in HE compared to control mares. No pathological arrhythmias or differences in splenic volume or PCV were detected. Conclusions: Ingesting a HE diet first induced minor changes in BP, and progressed to left-sided cardiac hypertrophy in Shetland pony mares. These findings are of interest given the increasing incidence of obesity in horses.
© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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Publication Date: 2021-08-05 PubMed ID: 34350640PubMed Central: PMC8478035DOI: 10.1111/jvim.16229Google Scholar: Lookup
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Summary

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The research examines how a long-term high-energy (HE) diet influences cardiovascular parameters in Shetland pony mares, finding that such a diet first leads to minor changes in blood pressure (BP), and then to left-sided cardiac hypertrophy.

Study Objective

  • The primary objective of this research was to figure out the chronology of changes in cardiovascular parameters related to Equine Metabolic Syndrome (EMS), a condition similar to metabolic syndrome in humans. This is achieved by observing the effects of a long-term high-energy diet on Shetland pony mares.

Methods

  • Twenty Shetland pony mares participated in the research. Some were fed a high-energy diet providing 200% of their net energy requirements for one or two consecutive years, with 17 weeks of hay-only diet in between the years. This group is referred to as the HE diet group.
  • The others were maintained on a diet suitable for their needs for one or two consecutive years. They are considered the control group.
  • During both years, researchers carried out noninvasive BP measurements and echocardiograms. At the end of the first diet year, resting 24-hour ECGs and measures of autonomic tone (i.e., splenic volume and packed cell volume [PCV]) were also performed.

Results

  • In the first year of the diet, the mares on the high-energy diet had significantly higher relative left ventricular wall thickness compared to the control group.
  • By the end of the second year of the diet, the HE diet group showed significantly increased mean systolic, diastolic, and mean arterial BP, heart rate, and left ventricular wall thickness than the control group.
  • Despite these changes, no pathological arrhythmias or distinctions in splenic volume or PCV were found.

Conclusion

  • The research concludes that consuming a high-energy diet initially causes minor changes in BP and then leads to left-sided cardiac hypertrophy in Shetland pony mares. Considering the rising incidence of obesity in horses, this is crucial information. It suggests that a diet high in energy could put equines at risk of developing heart disease.

Cite This Article

APA
D' Fonseca NMM, Beukers M, Wijnberg ID, Navas de Solis C, de Ruijter-Villani M, van Doorn DA, Stout TAE, Roelfsema E. (2021). Effect of a long-term high-energy diet on cardiovascular parameters in Shetland pony mares. J Vet Intern Med, 35(5), 2427-2436. https://doi.org/10.1111/jvim.16229

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 35
Issue: 5
Pages: 2427-2436

Researcher Affiliations

D' Fonseca, Nicky M M
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Beukers, Martjin
  • Division of Diagnostic Imaging, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Wijnberg, Inge D
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Navas de Solis, Cristobal
  • Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Philadelphia, PA, USA.
de Ruijter-Villani, Marta
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
van Doorn, David A
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Division of Nutrition, Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Stout, Tom A E
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Roelfsema, Ellen
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

MeSH Terms

  • Animals
  • Diet / veterinary
  • Female
  • Heart Rate
  • Horse Diseases
  • Horses
  • Metabolic Syndrome / veterinary
  • Obesity / veterinary

Grant Funding

  • 317146 / FP7 People: Marie-Curie Actions
  • PAVO

Conflict of Interest Statement

Authors declare no conflict of interest.

References

This article includes 36 references
  1. Durham AE, Frank N, McGowan CM. ECEIM consensus statement on equine metabolic syndrome. J Vet Intern Med 2019;33(2):335‐349.
    pmc: PMC6430910pubmed: 30724412
  2. Heliczer N, Gerber V, Bruckmaier R, van der Kolk JH, de Solis CN. Cardiovascular findings in ponies with equine metabolic syndrome. J Am Vet Med Assoc 2017;250(9):1027‐1035.
    pubmed: 28414603
  3. Bailey SR, Habershon‐Butcher JL, Ransom KJ, Elliott J, Menzies‐Gow NJ. Hypertension and insulin resistance in a mixed‐breed population of ponies predisposed to laminitis. Am J Vet Res 2008;69(1):122‐129.
    pubmed: 18167097
  4. Guangyuan Z, Nystrom Frederick H, Ravichandran Lingamanaidu V. Roles for insulin receptor, PI3‐kinase, and Akt in insulin‐signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 2000;101(13):1539‐1545.
    pubmed: 10747347
  5. Muniyappa R, Sowers J. Role of insulin resistance in endothelial dysfunction. Rev Endocr Metab Disord 2013;14(1):5‐12.
    pmc: PMC3594115pubmed: 23306778
  6. Natali A, Quiñones Galvan A, Santoro D. Relationship between insulin release, antinatriuresis and hypokalaemia after glucose ingestion in normal and hypertensive man. Clin Sci (Lond) 1993;85(3):327‐335.
    pubmed: 8403806
  7. DeFronzo RA, Cooke CR, Andres R, Faloona GR, Davis PJ. The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. J Clin Invest 1975;55(4):845‐855.
    pmc: PMC301822pubmed: 1120786
  8. Ferri C, Laurenti O, Bellini C. Circulating endothelin‐1 levels in lean non‐insulin‐dependent diabetic patients. Influence of ACE inhibition. Am J Hypertens 1995;8(1):40‐47.
    pubmed: 7734095
  9. Forte P, Copland M, Smith LM, Milne E, Sutherland J, Benjamin N. Basal nitric oxide synthesis in essential hypertension. Lancet 1997;349(9055):837‐842.
    pubmed: 9121259
  10. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996;97(11):2601‐2610.
    pmc: PMC507347pubmed: 8647954
  11. Nostell K, Lindåse S, Edberg H, Bröjer J. The effect of insulin infusion on heart rate and systemic blood pressure in horses with equine metabolic syndrome. Equine Vet J 2019;51(6):733‐737.
    pubmed: 30887546
  12. Nostell KEA, Lindåse SS, Bröjer JT. Blood pressure in Warmblood horses before and during a euglycemic‐hyperinsulinemic clamp. Acta Vet Scand 2016;58(Suppl 1):65.
    pmc: PMC5073943pubmed: 27766986
  13. Navas de Solis C, Slack J, Boston RC, Reef VB. Hypertensive cardiomyopathy in horses: 5 cases (1995–2011). J Am Vet Med Assoc 2013;243(1):126‐130.
    pubmed: 23786201
  14. Ghali JK, Kadakia S, Cooper RS, Liao Y. Impact of left ventricular hypertrophy on ventricular arrhythmias in the absence of coronary artery disease. J Am Coll Cardiol 1991;17(6):1277‐1282.
    pubmed: 1826691
  15. Moreira MCDS, Pinto ISJ, Mourão AA. Does the sympathetic nervous system contribute to the pathophysiology of metabolic syndrome?. Front Physiol 2015;6:234.
    pmc: PMC4548210pubmed: 26379553
  16. Henneke DR, Potter GD, Kreider JL, Yeates BF. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J 1983;15(4):371‐372.
    pubmed: 6641685
  17. Bamford NJ, Potter SJ, Harris PA, Bailey SR. Breed differences in insulin sensitivity and insulinemic responses to oral glucose in horses and ponies of moderate body condition score. Domest Anim Endocrinol 2014;47:101‐107.
    pubmed: 24308928
  18. d' Fonseca NMM, CME G, van Doorn DA, de Ruijter‐Villani M, TAE S, Roelfsema E. Effect of long‐term overfeeding of a high‐energy diet on glucose tolerance in Shetland pony mares. J Vet Intern Med 2020;34:1339‐1349.
    pmc: PMC7255650pubmed: 32374454
  19. de Laat MA. Equine hyperinsulinemia: investigation of the enteroinsular axis during insulin dysregulation. Am J Physiol Endocrinol Metab 2015;310(1):E61‐E72.
    pubmed: 26530154
  20. Siegers EW, De Ruijter‐Villani M, Van Doorn DA, Stout TAE, Roelfsema E. Ultrasonographic measurements of localized fat accumulation in Shetland pony mares fed a normal v. a high energy diet for 2 years. Animal 2018;12(8):1602‐1610.
    pubmed: 29198235
  21. Centraal Veevoederbureau. Het EWpa en VREp systeem. CVB documentatierapport No. 31, Centraal Veevoederbureau, Lelystad, the Netherlands 497 (in Dutch) 2004.
  22. Carter RA, McCutcheon LJ, George LA, Smith TL, Frank N, Geor RJ. Effects of diet‐induced weight gain on insulin sensitivity and plasma hormone and lipid concentrations in horses. Am J Vet Res 2009;70(10):1250‐1258.
    pubmed: 19795940
  23. Parry BW, McCarthy MA, Anderson GA. Survey of resting blood pressure values in clinically normal horses. Equine Vet J 1984;16(1):53‐58.
    pubmed: 6714207
  24. Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 1977;55(4):613‐618.
    pubmed: 138494
  25. O'Callaghan MW. Comparison of echocardiographic and autopsy measurements of cardiac dimensions in the horse. Equine Vet J 1985;17(5):361‐368.
    pubmed: 4054086
  26. Navas de Solis C, Foreman JH, Byron CR, Carpenter RE. Ultrasonographic measurement of spleen volume in horses. Comp Exerc Physiol 2012;8(1):19‐25.
  27. Slater JD, Herrtage ME. Echocardiographic measurements of cardiac dimensions in normal ponies and horses. Equine Vet J 1995;27:28‐32.
    pubmed: 8933066
  28. Shawaf T, Hussen J, Al‐Zoubi M, Hamaash H, Al‐Busadah K. Impact of season, age and gender on some clinical, haematological and serum parameters in Shetland ponies in east province, Saudi Arabia. Int J Vet Sci Med 2018;6(1):61‐64.
    pmc: PMC6148337pubmed: 30255080
  29. Zhang K, Chen J, Liu Y. Diastolic blood pressure reduction contributes more to the regression of left ventricular hypertrophy: a meta‐analysis of randomized controlled trials. J Hum Hypertens 2013;27(11):698‐706.
    pubmed: 23535988
  30. Morgan RA, Keen JA, Walker BR, Hadoke PWF. Vascular dysfunction in horses with endocrinopathic laminitis. PLoS One 2016;11(9):e0163815.
    pmc: PMC5042533pubmed: 27684374
  31. Nostell K, Lindåse S, Winqvist E, Bröjer J. The effect of diet‐induced obesity and pasture on blood pressure and serum cortisol in Standardbred mares. Equine Vet J 2021;53:542‐548.
    pubmed: 32483866
  32. Simonds SE, Pryor JT, Ravussin E. Leptin mediates the increase in blood pressure associated with obesity. Cell 2014;159(6):1404‐1416.
    pmc: PMC4259491pubmed: 25480301
  33. Rahmouni K, Morgan DA, Morgan GM, Mark AL, Haynes WG. Role of selective leptin resistance in diet‐induced obesity hypertension. Diabetes 2005;54(7):2012‐2018.
    pubmed: 15983201
  34. Kassab S, Kato T, Wilkins FC, Chen R, Hall JE, Granger JP. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension 1995;25(4):893‐897.
    pubmed: 7721450
  35. Massiéra F, Bloch‐Faure M, Ceiler D. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J 2001;15(14):1‐25.
    pubmed: 11606482
  36. Grassi G, Vailati S, Bertinieri G. Heart rate as marker of sympathetic activity. J Hypertens 1998;16(11):1635‐1639.
    pubmed: 9856364
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